Biodistribution (ADMET)
|
= 0.04 %
|
Biodistribution of the compound in fat of mature female Dawley rat after 3 h, expressed as percent inected dose/g
|
ChEMBL.
|
8978842
|
Biodistribution (ADMET)
|
= 0.07 %
|
Biodistribution of the compound in fat of mature female Dawley rat after 30min, expressed as percent inected dose/g
|
ChEMBL.
|
8978842
|
Biodistribution (ADMET)
|
= 0.07 %
|
Biodistribution of the compound in fat of mature female Dawley rat after 1h, expressed as percent inected dose/g
|
ChEMBL.
|
8978842
|
Biodistribution (ADMET)
|
= 0.08 %
|
Biodistribution of the compound in fat of mature female Dawley rat after 10min, expressed as percent inected dose/g
|
ChEMBL.
|
8978842
|
Biodistribution (ADMET)
|
= 0.14 %
|
Biodistribution of the compound in brain of mature female Dawley rat after 10min, expressed as percent inected dose/g
|
ChEMBL.
|
8978842
|
Biodistribution (ADMET)
|
= 0.14 %
|
Biodistribution of the compound in muscle of mature female Dawley rat after 3 h, expressed as percent inected dose/g
|
ChEMBL.
|
8978842
|
Biodistribution (ADMET)
|
= 0.15 %
|
Biodistribution of the compound in brainof mature female Dawley rat after 30min, expressed as percent inected dose/g
|
ChEMBL.
|
8978842
|
Biodistribution (ADMET)
|
= 0.16 %
|
Biodistribution of the compound inl iver of mature female Dawley rat after 3 h, expressed as percent inected dose/g
|
ChEMBL.
|
8978842
|
Biodistribution (ADMET)
|
= 0.16 %
|
Biodistribution of the compound in heart of mature female Dawley rat after 3 h, expressed as percent inected dose/g
|
ChEMBL.
|
8978842
|
Biodistribution (ADMET)
|
= 0.16 %
|
Biodistribution of the compound in brain of mature female Dawley rat after 3 h, expressed as percent inected dose/g
|
ChEMBL.
|
8978842
|
Biodistribution (ADMET)
|
= 0.16 %
|
Biodistribution of the compound in abdominal of mature female Dawley rat after 3 h, expressed as percent inected dose/g
|
ChEMBL.
|
8978842
|
Biodistribution (ADMET)
|
= 0.17 %
|
Biodistribution of the compound in brain of mature female Dawley rat after 1h, expressed as percent inected dose/g
|
ChEMBL.
|
8978842
|
Biodistribution (ADMET)
|
= 0.17 %
|
Biodistribution of the compound in lungof mature female Dawley rat after 3 h, expressed as percent inected dose/g
|
ChEMBL.
|
8978842
|
Biodistribution (ADMET)
|
= 0.19 %
|
Biodistribution of the compound in blood of mature female Dawley rat after 3 h, expressed as percent inected dose/g
|
ChEMBL.
|
8978842
|
Biodistribution (ADMET)
|
= 0.21 %
|
Biodistribution of the compound in kidney of mature female Dawley rat after 3 h, expressed as percent inected dose/g
|
ChEMBL.
|
8978842
|
Biodistribution (ADMET)
|
= 0.26 %
|
Biodistribution of the compound in abdominal of mature female Dawley rat after 1h, expressed as percent inected dose/g
|
ChEMBL.
|
8978842
|
Biodistribution (ADMET)
|
= 0.27 %
|
Biodistribution of the compound in blood of mature female Dawley rat after 30min, expressed as percent inected dose/g
|
ChEMBL.
|
8978842
|
Biodistribution (ADMET)
|
= 0.29 %
|
Biodistribution of the compound in heart of mature female Dawley rat after 1h, expressed as percent inected dose/g
|
ChEMBL.
|
8978842
|
Biodistribution (ADMET)
|
= 0.31 %
|
Biodistribution of the compound in abdominal Dawley rat after 30min, expressed as percent inected dose/g
|
ChEMBL.
|
8978842
|
Biodistribution (ADMET)
|
= 0.32 %
|
Biodistribution of the compound in blood of mature female Dawley rat after 10min, expressed as percent inected dose/g
|
ChEMBL.
|
8978842
|
Biodistribution (ADMET)
|
= 0.32 %
|
Biodistribution of the compound in blood of mature female Dawley rat after 1h, expressed as percent inected dose/g
|
ChEMBL.
|
8978842
|
Biodistribution (ADMET)
|
= 0.32 %
|
Biodistribution of the compound in muscle of mature female Dawley rat after 1h, expressed as percent inected dose/g
|
ChEMBL.
|
8978842
|
Biodistribution (ADMET)
|
= 0.33 %
|
Biodistribution of the compound in muscle of mature female Dawley rat after 10min, expressed as percent inected dose/g
|
ChEMBL.
|
8978842
|
Biodistribution (ADMET)
|
= 0.35 %
|
Biodistribution of the compound inl liver of mature female Dawley rat after 1h, expressed as percent inected dose/g
|
ChEMBL.
|
8978842
|
Biodistribution (ADMET)
|
= 0.37 %
|
Biodistribution of the compound in heart of mature female Dawley rat after 30min, expressed as percent inected dose/g
|
ChEMBL.
|
8978842
|
Biodistribution (ADMET)
|
= 0.38 %
|
Biodistribution of the compound in abdominal of mature female Dawley rat after 10min, expressed as percent inected dose/g
|
ChEMBL.
|
8978842
|
Biodistribution (ADMET)
|
= 0.38 %
|
Biodistribution of the compound in muscle of mature female Dawley rat after 30min, expressed as percent inected dose/g
|
ChEMBL.
|
8978842
|
Biodistribution (ADMET)
|
= 0.38 %
|
Biodistribution of the compound in lungof mature female Dawley rat after 1h, expressed as percent inected dose/g
|
ChEMBL.
|
8978842
|
Biodistribution (ADMET)
|
= 0.51 %
|
Biodistribution of the compound inl ilver of mature female Dawley rat after 30min, expressed as percent inected dose/g
|
ChEMBL.
|
8978842
|
Biodistribution (ADMET)
|
= 0.55 %
|
Biodistribution of the compound in bone of mature female Dawley rat after 10min, expressed as percent inected dose/g
|
ChEMBL.
|
8978842
|
Biodistribution (ADMET)
|
= 0.57 %
|
Biodistribution of the compound in lungof mature female Dawley rat after 30min, expressed as percent inected dose/g
|
ChEMBL.
|
8978842
|
Biodistribution (ADMET)
|
= 0.62 %
|
Biodistribution of the compound in heart of mature female Dawley rat after 10min, expressed as percent inected dose/g
|
ChEMBL.
|
8978842
|
Biodistribution (ADMET)
|
= 0.64 %
|
Biodistribution of the compound in kidney of mature female Dawley rat after 1h, expressed as percent inected dose/g
|
ChEMBL.
|
8978842
|
Biodistribution (ADMET)
|
= 0.82 %
|
Biodistribution of the compound in bone of mature female Dawley rat after 30min, expressed as percent inected dose/g
|
ChEMBL.
|
8978842
|
Biodistribution (ADMET)
|
= 0.88 %
|
Biodistribution of the compound in bone of mature female Dawley rat after 1h, expressed as percent inected dose/g
|
ChEMBL.
|
8978842
|
Biodistribution (ADMET)
|
= 0.95 %
|
Biodistribution of the compound in liver of mature female Dawley rat after 10min, expressed as percent inected dose/g
|
ChEMBL.
|
8978842
|
Biodistribution (ADMET)
|
= 1.02 %
|
Biodistribution of the compound in lung of mature female Dawley rat after 10min, expressed as percent inected dose/g
|
ChEMBL.
|
8978842
|
Biodistribution (ADMET)
|
= 1.06 %
|
Biodistribution of the compound in kidney of mature female Dawley rat after 30min, expressed as percent inected dose/g
|
ChEMBL.
|
8978842
|
Biodistribution (ADMET)
|
= 1.19 %
|
Biodistribution of the compound in bone of mature female Dawley rat after 3 h, expressed as percent inected dose/g
|
ChEMBL.
|
8978842
|
Biodistribution (ADMET)
|
= 1.82 %
|
Biodistribution of the compound in kidney of mature female Dawley rat after 10min, expressed as percent inected dose/g
|
ChEMBL.
|
8978842
|
IC50 (binding)
|
= 0.14 uM
|
The compound was evaluated for the inhibitory potencies using human Inducible nitric oxide synthase (hiNOS)
|
ChEMBL.
|
8978842
|
IC50 (binding)
|
= 0.14 uM
|
The compound was evaluated for the inhibitory potencies using human Inducible nitric oxide synthase (hiNOS)
|
ChEMBL.
|
8978842
|
IC50 (binding)
|
= 1.26 uM
|
The compound was evaluated for the inhibitory potencies using human Endothelial nitric oxide synthase
|
ChEMBL.
|
8978842
|
IC50 (binding)
|
= 1.26 uM
|
The compound was evaluated for the inhibitory potencies using human Endothelial nitric oxide synthase
|
ChEMBL.
|
8978842
|
logD |
= 0.73
|
Partition coefficient measured by octanol/water extraction at pH 6.8
|
ChEMBL.
|
8978842
|
Selectivity ratio (binding)
|
= 9
|
Selectivity ratio of Inhibition of (hiNOS) vs (heNOS).
|
ChEMBL.
|
8978842
|