Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.0317 | 1 | 1 |
Plasmodium falciparum | AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative | 0.002 | 0 | 0.5 |
Plasmodium vivax | AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative | 0.002 | 0 | 0.5 |
Leishmania major | apurinic/apyrimidinic endonuclease-redox protein | 0.002 | 0 | 0.5 |
Loa Loa (eye worm) | NNMT/PNMT/TEMT family protein | 0.0317 | 1 | 1 |
Trypanosoma brucei | apurinic/apyrimidinic endonuclease, putative | 0.002 | 0 | 0.5 |
Trichomonas vaginalis | ap endonuclease, putative | 0.002 | 0 | 0.5 |
Trypanosoma cruzi | apurinic/apyrimidinic endonuclease | 0.002 | 0 | 0.5 |
Treponema pallidum | exodeoxyribonuclease (exoA) | 0.002 | 0 | 0.5 |
Echinococcus granulosus | geminin | 0.0194 | 0.5872 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0194 | 0.5872 | 1 |
Entamoeba histolytica | exodeoxyribonuclease III, putative | 0.002 | 0 | 0.5 |
Trypanosoma cruzi | apurinic/apyrimidinic endonuclease, putative | 0.002 | 0 | 0.5 |
Trichomonas vaginalis | ap endonuclease, putative | 0.002 | 0 | 0.5 |
Mycobacterium tuberculosis | Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) | 0.002 | 0 | 0.5 |
Giardia lamblia | Endonuclease/Exonuclease/phosphatase | 0.002 | 0 | 0.5 |
Mycobacterium ulcerans | exodeoxyribonuclease III protein XthA | 0.002 | 0 | 0.5 |
Toxoplasma gondii | exonuclease III APE | 0.002 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0317 | 1 | 1 |
Wolbachia endosymbiont of Brugia malayi | exonuclease III | 0.002 | 0 | 0.5 |
Echinococcus multilocularis | geminin | 0.0194 | 0.5872 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0194 | 0.5872 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (functional) | = 8 % | Compound was evaluated for antihelminthic activity in the diet against Nematospiroides dubius in mice at a concentration 0.013% | ChEMBL. | 4032426 |
Activity (functional) | = 35 % | Compound was evaluated for antihelminthic activity in the diet against Nematospiroides dubius in mice at a concentration 0.025% | ChEMBL. | 4032426 |
Activity (functional) | = 46 % | Compound was evaluated for antihelminthic activity in the diet against Nematospiroides dubius in mice at a concentration 0.05% | ChEMBL. | 4032426 |
Activity (functional) | = 70 % | Compound was evaluated for antihelminthic activity in the diet against Nematospiroides dubius in mice at a concentration 0.1% | ChEMBL. | 4032426 |
Activity (functional) | = 93 % | Compound was evaluated for antihelminthic activity in the diet against Nematospiroides dubius in mice at concentration 0.2% | ChEMBL. | 4032426 |
Clearance (functional) | = 8 % | Compound was evaluated for antihelminthic activity in the diet against Nematospiroides dubius in mice at a concentration 0.013% | ChEMBL. | 4032426 |
Clearance (functional) | = 35 % | Compound was evaluated for antihelminthic activity in the diet against Nematospiroides dubius in mice at a concentration 0.025% | ChEMBL. | 4032426 |
Clearance (functional) | = 46 % | Compound was evaluated for antihelminthic activity in the diet against Nematospiroides dubius in mice at a concentration 0.05% | ChEMBL. | 4032426 |
Clearance (functional) | = 70 % | Compound was evaluated for antihelminthic activity in the diet against Nematospiroides dubius in mice at a concentration 0.1% | ChEMBL. | 4032426 |
Clearance (functional) | = 93 % | Compound was evaluated for antihelminthic activity in the diet against Nematospiroides dubius in mice at concentration 0.2% | ChEMBL. | 4032426 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.