Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Toxoplasma gondii | cytidine and deoxycytidylate deaminase zinc-binding region domain-containing protein | 0.048 | 1 | 0.5 |
Echinococcus granulosus | cytidine deaminase | 0.048 | 1 | 1 |
Mycobacterium leprae | PROBABLE CYTIDINE DEAMINASE CDD (CYTIDINE AMINOHYDROLASE) (CYTIDINE NUCLEOSIDE DEAMINASE) | 0.048 | 1 | 0.5 |
Trichomonas vaginalis | cytidine deaminase, putative | 0.048 | 1 | 0.5 |
Trichomonas vaginalis | cytidine deaminase, putative | 0.048 | 1 | 0.5 |
Entamoeba histolytica | cytidine deaminase, putative | 0.048 | 1 | 0.5 |
Onchocerca volvulus | 0.048 | 1 | 0.5 | |
Echinococcus multilocularis | cytidine deaminase | 0.048 | 1 | 1 |
Giardia lamblia | Cytidine deaminase | 0.048 | 1 | 0.5 |
Schistosoma mansoni | tar DNA-binding protein | 0.0068 | 0 | 0.5 |
Schistosoma mansoni | tar DNA-binding protein | 0.0068 | 0 | 0.5 |
Mycobacterium tuberculosis | Probable cytidine deaminase Cdd (cytidine aminohydrolase) (cytidine nucleoside deaminase) | 0.048 | 1 | 0.5 |
Loa Loa (eye worm) | TAR-binding protein | 0.0068 | 0 | 0.5 |
Loa Loa (eye worm) | RNA binding protein | 0.0068 | 0 | 0.5 |
Schistosoma mansoni | tar DNA-binding protein | 0.0068 | 0 | 0.5 |
Onchocerca volvulus | 0.048 | 1 | 0.5 | |
Schistosoma mansoni | tar DNA-binding protein | 0.0068 | 0 | 0.5 |
Trypanosoma cruzi | cytidine deaminase-like protein, putative | 0.048 | 1 | 0.5 |
Mycobacterium ulcerans | cytidine deaminase | 0.048 | 1 | 0.5 |
Schistosoma mansoni | tar DNA-binding protein | 0.0068 | 0 | 0.5 |
Trypanosoma cruzi | cytidine deaminase-like protein | 0.048 | 1 | 0.5 |
Trypanosoma brucei | cytidine deaminase | 0.048 | 1 | 0.5 |
Leishmania major | cytidine deaminase-like protein | 0.048 | 1 | 0.5 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0068 | 0 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
ED50 (functional) | = 0.4 mg kg-1 | Antidepressant activity of the compound using yohimbine potentiation test in mice | ChEMBL. | 7328583 |
ED50 (functional) | = 0.4 mg kg-1 | Antidepressant activity of the compound using yohimbine potentiation test in mice | ChEMBL. | 7328583 |
ED50 (functional) | = 9 mg kg-1 | Antidepressant activity of the compound using oxotremorine antagonism test in mice | ChEMBL. | 7328583 |
ED50 (functional) | = 9 mg kg-1 | Antidepressant activity of the compound using oxotremorine antagonism test in mice | ChEMBL. | 7328583 |
ED50 (functional) | = 20 mg kg-1 | Antidepressant activity using apomorphine potentiation test in mice | ChEMBL. | 7328583 |
ED50 (functional) | = 20 mg kg-1 | Antidepressant activity using apomorphine potentiation test in mice | ChEMBL. | 7328583 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.