Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Entamoeba histolytica | aldose reductase, putative | 0.0428 | 1 | 0.5 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.0428 | 1 | 1 |
Echinococcus granulosus | aldo keto reductase family 1 member B4 | 0.0428 | 1 | 1 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.0428 | 1 | 1 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.0428 | 1 | 1 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.0428 | 1 | 0.5 |
Leishmania major | aldehyde reductase, putative,oxidoreductase, putative | 0.0428 | 1 | 0.5 |
Trypanosoma cruzi | aldo-keto reductase | 0.0428 | 1 | 0.5 |
Echinococcus multilocularis | aldo keto reductase | 0.0428 | 1 | 1 |
Onchocerca volvulus | 0.0428 | 1 | 0.5 | |
Echinococcus multilocularis | aldo keto reductase | 0.0428 | 1 | 1 |
Echinococcus granulosus | aldo keto reductase family 1 member B4 | 0.0428 | 1 | 1 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.0428 | 1 | 0.5 |
Echinococcus granulosus | aldo keto reductase | 0.0428 | 1 | 1 |
Loa Loa (eye worm) | oxidoreductase | 0.0428 | 1 | 0.5 |
Schistosoma mansoni | aldo-keto reductase | 0.0428 | 1 | 0.5 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.0428 | 1 | 0.5 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.0428 | 1 | 1 |
Onchocerca volvulus | 0.0428 | 1 | 0.5 | |
Giardia lamblia | Aldose reductase | 0.0428 | 1 | 0.5 |
Mycobacterium leprae | PROBABLE OXIDOREDUCTASE | 0.0428 | 1 | 1 |
Echinococcus granulosus | aldo keto reductase family 1 member B4 | 0.0428 | 1 | 1 |
Toxoplasma gondii | aldose reductase, putative | 0.0428 | 1 | 0.5 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.0428 | 1 | 0.5 |
Entamoeba histolytica | aldose reductase, putative | 0.0428 | 1 | 0.5 |
Giardia lamblia | Aldose reductase | 0.0428 | 1 | 0.5 |
Entamoeba histolytica | aldose reductase, putative | 0.0428 | 1 | 0.5 |
Echinococcus granulosus | aldo keto reductase family 1 member B4 | 0.0428 | 1 | 1 |
Echinococcus granulosus | aldo keto reductase family 1 member B4 | 0.0428 | 1 | 1 |
Mycobacterium ulcerans | oxidoreductase | 0.0428 | 1 | 0.5 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.0428 | 1 | 1 |
Schistosoma mansoni | pol-related | 0.0428 | 1 | 0.5 |
Onchocerca volvulus | 0.0428 | 1 | 0.5 | |
Brugia malayi | oxidoreductase, aldo/keto reductase family protein | 0.0428 | 1 | 0.5 |
Trypanosoma brucei | aldo-keto reductase, putative | 0.0428 | 1 | 0.5 |
Echinococcus granulosus | aldo keto reductase family 1 member B4 | 0.0428 | 1 | 1 |
Trypanosoma brucei | prostaglandin f synthase | 0.0428 | 1 | 0.5 |
Echinococcus granulosus | aldo keto reductase | 0.0428 | 1 | 1 |
Onchocerca volvulus | 0.0428 | 1 | 0.5 | |
Mycobacterium tuberculosis | Probable oxidoreductase | 0.0428 | 1 | 0.5 |
Trichomonas vaginalis | dihydrodiol dehydrogenase, putative | 0.0428 | 1 | 0.5 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.0428 | 1 | 0.5 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.0428 | 1 | 1 |
Echinococcus multilocularis | aldo keto reductase | 0.0428 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0428 | 1 | 0.5 |
Trichomonas vaginalis | aldo/keto reductase, putative | 0.0428 | 1 | 0.5 |
Trichomonas vaginalis | aldo/keto reductase, putative | 0.0428 | 1 | 0.5 |
Echinococcus multilocularis | aldo keto reductase | 0.0428 | 1 | 1 |
Loa Loa (eye worm) | oxidoreductase | 0.0428 | 1 | 0.5 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.0428 | 1 | 0.5 |
Echinococcus granulosus | aldo keto reductase family 1 member B4 | 0.0428 | 1 | 1 |
Brugia malayi | oxidoreductase, aldo/keto reductase family protein | 0.0428 | 1 | 0.5 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.0428 | 1 | 1 |
Leishmania major | prostaglandin f2-alpha synthase/D-arabinose dehydrogenase | 0.0428 | 1 | 0.5 |
Trichomonas vaginalis | dihydrodiol dehydrogenase, putative | 0.0428 | 1 | 0.5 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.0428 | 1 | 0.5 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.0428 | 1 | 0.5 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.0428 | 1 | 1 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.0428 | 1 | 0.5 |
Echinococcus granulosus | aldo keto reductase family 1 member B4 | 0.0428 | 1 | 1 |
Echinococcus granulosus | hypothetical protein | 0.0428 | 1 | 1 |
Loa Loa (eye worm) | oxidoreductase | 0.0428 | 1 | 0.5 |
Leishmania major | aldo-keto reductase-like protein | 0.0428 | 1 | 0.5 |
Brugia malayi | oxidoreductase, aldo/keto reductase family protein | 0.0428 | 1 | 0.5 |
Trypanosoma cruzi | aldo/keto reductase, putative | 0.0428 | 1 | 0.5 |
Loa Loa (eye worm) | oxidoreductase | 0.0428 | 1 | 0.5 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.0428 | 1 | 0.5 |
Echinococcus granulosus | aldo keto reductase family 1 member B4 | 0.0428 | 1 | 1 |
Loa Loa (eye worm) | oxidoreductase | 0.0428 | 1 | 0.5 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.0428 | 1 | 1 |
Trichomonas vaginalis | dihydrodiol dehydrogenase, putative | 0.0428 | 1 | 0.5 |
Onchocerca volvulus | 0.0428 | 1 | 0.5 | |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.0428 | 1 | 1 |
Onchocerca volvulus | 0.0428 | 1 | 0.5 | |
Leishmania major | prostaglandin f synthase, putative | 0.0428 | 1 | 0.5 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.0428 | 1 | 1 |
Echinococcus granulosus | aldo keto reductase | 0.0428 | 1 | 1 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.0428 | 1 | 0.5 |
Trichomonas vaginalis | aldo/keto reductase, putative | 0.0428 | 1 | 0.5 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.0428 | 1 | 0.5 |
Schistosoma mansoni | aldo-keto reductase | 0.0428 | 1 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
MIC (functional) | = 8 ug ml-1 | Minimum inhibitory concentration to inhibit 90 to 100% visible growth of Candida albicans | ChEMBL. | 12565963 |
MIC (functional) | = 8 ug ml-1 | Minimum inhibitory concentration to inhibit 90 to 100% visible growth of Candida albicans | ChEMBL. | 12565963 |
MIC (functional) | > 128 ug ml-1 | Minimum inhibitory concentration required to inhibit 90 to 100% visible growth of Candida glabrata | ChEMBL. | 12565963 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.