Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | glutamate NMDA receptor subunit | 0.041 | 0.6931 | 1 |
Echinococcus granulosus | glutamate receptor ionotrophic AMPA 3 | 0.0205 | 0.226 | 0.2379 |
Onchocerca volvulus | 0.0121 | 0.0338 | 1 | |
Loa Loa (eye worm) | glutamate receptor 2 | 0.0173 | 0.1512 | 1 |
Schistosoma mansoni | glutamate receptor kainate | 0.0173 | 0.1512 | 0.1215 |
Brugia malayi | Glutamate receptor 2 precursor | 0.0173 | 0.1512 | 1 |
Schistosoma mansoni | ATP-binding cassette transporter | 0.0173 | 0.1512 | 0.1215 |
Echinococcus multilocularis | glutamate (NMDA) receptor subunit | 0.041 | 0.6931 | 1 |
Echinococcus granulosus | nmda type glutamate receptor | 0.0372 | 0.6061 | 0.858 |
Schistosoma mansoni | glutamate receptor AMPA | 0.0173 | 0.1512 | 0.1215 |
Echinococcus multilocularis | nmda type glutamate receptor | 0.0403 | 0.6771 | 0.974 |
Echinococcus multilocularis | glutamate receptor, ionotrophic, AMPA 3 | 0.0205 | 0.226 | 0.2379 |
Echinococcus granulosus | glutamate receptor 2 | 0.0205 | 0.226 | 0.2379 |
Schistosoma mansoni | glutamate receptor kainate | 0.0173 | 0.1512 | 0.1215 |
Echinococcus multilocularis | Glutamate receptor, ionotropic kainate 2 | 0.0205 | 0.226 | 0.2379 |
Echinococcus granulosus | Glutamate receptor ionotropic kainate 2 | 0.0205 | 0.226 | 0.2379 |
Schistosoma mansoni | glutamate receptor kainate | 0.0173 | 0.1512 | 0.1215 |
Echinococcus multilocularis | glutamate receptor NMDA | 0.0339 | 0.5313 | 0.7361 |
Echinococcus granulosus | Glutamate receptor ionotropic kainate 2 | 0.0205 | 0.226 | 0.2379 |
Echinococcus multilocularis | glutamate receptor 2 | 0.0205 | 0.226 | 0.2379 |
Echinococcus multilocularis | Glutamate receptor, ionotropic kainate 2 | 0.0205 | 0.226 | 0.2379 |
Schistosoma mansoni | glutamate receptor AMPA | 0.0173 | 0.1512 | 0.1215 |
Brugia malayi | Glutamate receptor 1 precursor | 0.0173 | 0.1512 | 1 |
Echinococcus granulosus | Glutamate receptor ionotropic kainate 2 | 0.0205 | 0.226 | 0.2379 |
Echinococcus multilocularis | Glutamate receptor, ionotropic kainate 2 | 0.0205 | 0.226 | 0.2379 |
Echinococcus granulosus | nmda type glutamate receptor | 0.0403 | 0.6771 | 0.974 |
Echinococcus multilocularis | nmda type glutamate receptor | 0.0372 | 0.6061 | 0.858 |
Echinococcus multilocularis | glutamate receptor 2 | 0.0173 | 0.1512 | 0.1159 |
Schistosoma mansoni | glutamate receptor NMDA | 0.041 | 0.6931 | 0.6823 |
Echinococcus granulosus | glutamate receptor NMDA | 0.0339 | 0.5313 | 0.7361 |
Loa Loa (eye worm) | glutamate receptor 1 | 0.0173 | 0.1512 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
I50 (binding) | = 19800000000 M | Inhibition of human acrosin and control activity being 11.3 umol/min/mg | ChEMBL. | 3514912 |
I50 (binding) | = 27700000000 M | Inhibition of human trypsin and the control activity being 7.3 umol/min/mg | ChEMBL. | 3514912 |
LD50 (ADMET) | = 240 mg kg-1 | Lethal dose of the compound that produces death in 50% of mice within 24 hr after acute treatment | ChEMBL. | 3514912 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.