Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Leishmania major | hypothetical protein, conserved | 0.0075 | 0.2304 | 0.2304 |
Onchocerca volvulus | 0.0086 | 0.3627 | 0.1719 | |
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | 0.0108 | 0.6197 | 0.5058 |
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | 0.0108 | 0.6197 | 0.5058 |
Mycobacterium tuberculosis | Probable protease II PtrBa [first part] (oligopeptidase B) | 0.0125 | 0.8259 | 1 |
Echinococcus granulosus | prolyl endopeptidase | 0.014 | 1 | 1 |
Mycobacterium ulcerans | protease II (oligopeptidase B), PtrB | 0.0056 | 0 | 0.5 |
Trypanosoma cruzi | prolyl endopeptidase | 0.014 | 1 | 1 |
Plasmodium vivax | cysteine repeat modular protein 1, putative | 0.0075 | 0.2304 | 0.5 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0075 | 0.2304 | 0.2304 |
Onchocerca volvulus | 0.0108 | 0.6197 | 0.5058 | |
Schistosoma mansoni | prolyl oligopeptidase (S09 family) | 0.014 | 1 | 1 |
Mycobacterium leprae | PROBABLE PROTEASE II PTRBB (OLIGOPEPTIDASE B) | 0.0056 | 0 | 0.5 |
Brugia malayi | Trypsin family protein | 0.0108 | 0.6197 | 0.5058 |
Loa Loa (eye worm) | hypothetical protein | 0.014 | 1 | 1 |
Leishmania major | prolyl oligopeptidase, putative,serine peptidase clan SC, family S9A, putative | 0.014 | 1 | 1 |
Schistosoma mansoni | prolyl oligopeptidase (S09 family) | 0.014 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0108 | 0.6197 | 0.5058 |
Onchocerca volvulus | Prolyl endopeptidase homolog | 0.014 | 1 | 1 |
Toxoplasma gondii | prolyl endopeptidase | 0.014 | 1 | 1 |
Plasmodium falciparum | cysteine repeat modular protein 1 | 0.0075 | 0.2304 | 0.5 |
Echinococcus multilocularis | prolyl endopeptidase | 0.014 | 1 | 1 |
Trypanosoma brucei | prolyl endopeptidase | 0.014 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0108 | 0.6197 | 0.5058 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
AUC (ADMET) | = 258 nM hr | Tested for the pharmacokinetic data, area under the curve of concentration versus time in dog | ChEMBL. | 11844665 |
Cmax (ADMET) | = 264 nM | Tested for the pharmacokinetic data, maximum concentration (Cmax) of the compound in dog | ChEMBL. | 11844665 |
T max (ADMET) | = 40 nM | Tested for the pharmacokinetic data, time required to reach Cmax (Tmax) of the compound in dog | ChEMBL. | 11844665 |
T1/2 (ADMET) | = 44.6 min | Tested for the half life period of the compound in dog | ChEMBL. | 11844665 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.