Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Mus musculus | prostaglandin-endoperoxide synthase 2 | Starlite/ChEMBL | References |
Ovis aries | Cyclooxygenase-1 | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Leishmania major | inosine-5-monophosphate dehydrogenase | 0.0173 | 1 | 0.5 |
Trypanosoma cruzi | inosine-5'-monophosphate dehydrogenase, putative | 0.0173 | 1 | 0.5 |
Mycobacterium ulcerans | inosine 5'-monophosphate dehydrogenase | 0.0173 | 1 | 1 |
Onchocerca volvulus | 0.0079 | 0 | 0.5 | |
Echinococcus multilocularis | inosine 5' monophosphate dehydrogenase 2 | 0.0173 | 1 | 1 |
Toxoplasma gondii | IMP dehydrogenas | 0.0173 | 1 | 0.5 |
Trypanosoma cruzi | GMP reductase | 0.0173 | 1 | 0.5 |
Onchocerca volvulus | Peroxidasin homolog | 0.0079 | 0 | 0.5 |
Leishmania major | guanosine monophosphate reductase | 0.0173 | 1 | 0.5 |
Onchocerca volvulus | Chorion peroxidase homolog | 0.0079 | 0 | 0.5 |
Onchocerca volvulus | Peroxidasin homolog | 0.0079 | 0 | 0.5 |
Trypanosoma cruzi | GMP reductase | 0.0173 | 1 | 0.5 |
Mycobacterium leprae | Probable inosine-5'-monophosphate dehydrogenase GuaB2 (IMP dehydrogenase) (IMPDH) (IMPD) | 0.0173 | 1 | 1 |
Plasmodium falciparum | inosine-5'-monophosphate dehydrogenase | 0.0162 | 0.8901 | 0.5 |
Trypanosoma brucei | GMP reductase | 0.0173 | 1 | 0.5 |
Onchocerca volvulus | 0.0079 | 0 | 0.5 | |
Onchocerca volvulus | Dual oxidase homolog | 0.0079 | 0 | 0.5 |
Trypanosoma cruzi | inosine-5'-monophosphate dehydrogenase, putative | 0.0173 | 1 | 0.5 |
Onchocerca volvulus | Peroxidase homolog | 0.0079 | 0 | 0.5 |
Loa Loa (eye worm) | IMP dehydrogenase 1 | 0.0173 | 1 | 1 |
Mycobacterium leprae | Probable inosine-5'-monophosphate dehydrogenase GuaB3 (IMP dehydrogenase 2) (inosinic acid dehydrogenase) (inosinate dehydrogena | 0.0091 | 0.1213 | 0.0954 |
Mycobacterium tuberculosis | Probable inosine-5'-monophosphate dehydrogenase GuaB2 (imp dehydrogenase) (inosinic acid dehydrogenase) (inosinate dehydrogenase | 0.0173 | 1 | 1 |
Schistosoma mansoni | inosine-5-monophosphate dehydrogenase | 0.0173 | 1 | 1 |
Trypanosoma cruzi | inosine-5'-monophosphate dehydrogenase, putative | 0.0173 | 1 | 0.5 |
Trypanosoma brucei | inosine-5'-monophosphate dehydrogenase | 0.0173 | 1 | 0.5 |
Onchocerca volvulus | Peroxidase homolog | 0.0079 | 0 | 0.5 |
Echinococcus granulosus | inosine 5' monophosphate dehydrogenase 2 | 0.0173 | 1 | 1 |
Mycobacterium ulcerans | inosine 5-monophosphate dehydrogenase | 0.0162 | 0.8901 | 0.8869 |
Plasmodium vivax | inosine-5'-monophosphate dehydrogenase, putative | 0.0162 | 0.8901 | 0.5 |
Wolbachia endosymbiont of Brugia malayi | IMP dehydrogenase | 0.0173 | 1 | 0.5 |
Onchocerca volvulus | 0.0079 | 0 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 0.15 uM | Inhibition of the ovine Prostaglandin G/H synthase 1 was determined by thin-layer chromatography assay | ChEMBL. | 11844663 |
IC50 (binding) | = 0.15 uM | Inhibition of the ovine Prostaglandin G/H synthase 1 was determined by thin-layer chromatography assay | ChEMBL. | 11844663 |
IC50 (binding) | = 0.4 uM | Inhibition of the wild type murine Prostaglandin G/H synthase 2 wildtype enzyme | ChEMBL. | 11844663 |
IC50 (binding) | = 0.4 uM | Inhibition of the wild type murine Prostaglandin G/H synthase 2 wildtype enzyme | ChEMBL. | 11844663 |
IC50 (binding) | = 0.55 uM | Inhibition of the Arg120Ala murine COX-2 mutant enzyme | ChEMBL. | 11844663 |
IC50 (binding) | = 0.55 uM | Inhibition of the Arg120Ala murine COX-2 mutant enzyme | ChEMBL. | 11844663 |
IC50 (binding) | = 1.8 uM | Inhibitory concentration against prostaglandin E2 | ChEMBL. | 11844663 |
IC50 (binding) | = 66 uM | Inhibition of the human Prostaglandin G/H synthase 2 was determined by thin-layer chromatography assay | ChEMBL. | 11844663 |
IC50 (binding) | = 66 uM | Inhibition of the human Prostaglandin G/H synthase 2 was determined by thin-layer chromatography assay | ChEMBL. | 11844663 |
Ratio (binding) | = 440 uM | Selectivity as ratio of IC50 against COX-1 to IC50 against COX-2 | ChEMBL. | 11844663 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.