Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0093 | 0.3598 | 0.3598 |
Mycobacterium tuberculosis | Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB | 0.0106 | 0.442 | 0.8342 |
Loa Loa (eye worm) | glycosyl hydrolase family 31 protein | 0.0158 | 0.7699 | 0.7699 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0049 | 0.0862 | 0.0862 |
Brugia malayi | ubiquitin conjugating enzyme protein 13 | 0.0195 | 1 | 1 |
Loa Loa (eye worm) | glutathione reductase | 0.0046 | 0.0705 | 0.0705 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0093 | 0.3598 | 0.3598 |
Brugia malayi | Thioredoxin reductase | 0.0046 | 0.0705 | 0.0705 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0049 | 0.0862 | 0.0862 |
Trypanosoma cruzi | ubiquitin-conjugating enzyme E2, putative | 0.0195 | 1 | 1 |
Plasmodium vivax | ubiquitin-conjugating enzyme E2 N, putative | 0.0195 | 1 | 1 |
Echinococcus granulosus | thioredoxin glutathione reductase | 0.0046 | 0.0705 | 0.0705 |
Trichomonas vaginalis | ubiquitin-conjugating enzyme E2, putative | 0.0195 | 1 | 1 |
Mycobacterium tuberculosis | Probable reductase | 0.0106 | 0.442 | 0.8342 |
Toxoplasma gondii | ubiquitin-conjugating enzyme subfamily protein | 0.0195 | 1 | 1 |
Entamoeba histolytica | ubiquitin-conjugating enzyme family protein | 0.0195 | 1 | 1 |
Trichomonas vaginalis | ubiquitin-conjugating enzyme E2, putative | 0.0195 | 1 | 1 |
Brugia malayi | Muscleblind-like protein | 0.0156 | 0.7561 | 0.7561 |
Trypanosoma brucei | ubiquitin-protein ligase, putative | 0.0195 | 1 | 1 |
Schistosoma mansoni | ubiquitin conjugating enzyme 13 | 0.0195 | 1 | 1 |
Mycobacterium leprae | DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE | 0.0117 | 0.5158 | 1 |
Loa Loa (eye worm) | ubiquitin conjugating enzyme protein 13 | 0.0195 | 1 | 1 |
Toxoplasma gondii | thioredoxin reductase | 0.0046 | 0.0705 | 0.0705 |
Trypanosoma cruzi | trypanothione reductase, putative | 0.0046 | 0.0705 | 0.0705 |
Mycobacterium tuberculosis | Probable oxidoreductase | 0.0117 | 0.5158 | 1 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0093 | 0.3598 | 0.3598 |
Trypanosoma brucei | trypanothione reductase | 0.0046 | 0.0705 | 0.0705 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0093 | 0.3598 | 0.3598 |
Leishmania major | ubiquitin-conjugating enzyme e2, putative | 0.0195 | 1 | 1 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0093 | 0.3598 | 0.3598 |
Loa Loa (eye worm) | ubiquitin conjugating enzyme protein 13 | 0.0195 | 1 | 1 |
Schistosoma mansoni | alpha-glucosidase | 0.0136 | 0.6321 | 0.6321 |
Trypanosoma cruzi | ubiquitin-conjugating enzyme E2, putative | 0.0195 | 1 | 1 |
Loa Loa (eye worm) | thioredoxin reductase | 0.0046 | 0.0705 | 0.0705 |
Echinococcus multilocularis | lysosomal alpha glucosidase | 0.0158 | 0.7699 | 0.7699 |
Loa Loa (eye worm) | hypothetical protein | 0.0156 | 0.7561 | 0.7561 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0093 | 0.3598 | 0.3598 |
Mycobacterium tuberculosis | Probable membrane NADH dehydrogenase NdhA | 0.0106 | 0.442 | 0.8342 |
Loa Loa (eye worm) | hypothetical protein | 0.0049 | 0.0862 | 0.0862 |
Echinococcus multilocularis | lysosomal alpha glucosidase | 0.0158 | 0.7699 | 0.7699 |
Echinococcus multilocularis | muscleblind protein 1 | 0.0156 | 0.7561 | 0.7561 |
Brugia malayi | glutathione reductase | 0.0046 | 0.0705 | 0.0705 |
Echinococcus granulosus | lysosomal alpha glucosidase | 0.0158 | 0.7699 | 0.7699 |
Leishmania major | trypanothione reductase | 0.0046 | 0.0705 | 0.0705 |
Schistosoma mansoni | alpha-glucosidase | 0.0136 | 0.6321 | 0.6321 |
Mycobacterium tuberculosis | Probable NADH dehydrogenase Ndh | 0.0106 | 0.442 | 0.8342 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0093 | 0.3598 | 0.3598 |
Echinococcus multilocularis | muscleblind protein | 0.0156 | 0.7561 | 0.7561 |
Echinococcus multilocularis | thioredoxin glutathione reductase | 0.0046 | 0.0705 | 0.0705 |
Mycobacterium tuberculosis | Probable dehydrogenase | 0.0106 | 0.442 | 0.8342 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0093 | 0.3598 | 0.3598 |
Brugia malayi | Glycosyl hydrolases family 31 protein | 0.0158 | 0.7699 | 0.7699 |
Plasmodium falciparum | ubiquitin-conjugating enzyme E2 N, putative | 0.0195 | 1 | 1 |
Echinococcus granulosus | ubiquitin conjugating enzyme E2 N | 0.0195 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0156 | 0.7561 | 0.7561 |
Mycobacterium tuberculosis | Putative ferredoxin reductase | 0.0106 | 0.442 | 0.8342 |
Echinococcus multilocularis | ubiquitin conjugating enzyme E2 N | 0.0195 | 1 | 1 |
Mycobacterium tuberculosis | NAD(P)H quinone reductase LpdA | 0.0117 | 0.5158 | 1 |
Mycobacterium tuberculosis | Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras | 0.0117 | 0.5158 | 1 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0093 | 0.3598 | 0.3598 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0049 | 0.0862 | 0.0862 |
Echinococcus granulosus | muscleblind protein | 0.0156 | 0.7561 | 0.7561 |
Onchocerca volvulus | 0.0091 | 0.3527 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
ED50 (functional) | = 178 mg kg-1 | Effective dose (po) evaluated by Passive cutaneous anaphylaxis test (PCA) by injecting IgE serum intradermally in mice | ChEMBL. | 1969485 |
ED50 (functional) | = 178 mg kg-1 | Effective dose (po) evaluated by Passive cutaneous anaphylaxis test (PCA) by injecting IgE serum intradermally in mice | ChEMBL. | 1969485 |
IC50 (functional) | NA 0 uM | Antiasthmatic activity against the immunoglobulin E (IgE) antigen using the human basophil asthma model; I = Inactive at 48 microM | ChEMBL. | 1969485 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.