Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Rattus norvegicus | Endothelin receptor ET-A | Starlite/ChEMBL | References |
Rattus norvegicus | Endothelin receptor ET-B | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Echinococcus granulosus | pyroglutamylated rfamide peptide receptor | Endothelin receptor ET-A | 426 aa | 412 aa | 20.1 % |
Onchocerca volvulus | Endothelin receptor ET-B | 442 aa | 445 aa | 20.9 % | |
Echinococcus multilocularis | pyroglutamylated rfamide peptide receptor | Endothelin receptor ET-A | 426 aa | 412 aa | 21.1 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | adam 17 protease | 0.0212 | 0.0096 | 0.2792 |
Trypanosoma brucei | Peptide deformylase 2 | 0.32 | 0.3716 | 0.5 |
Mycobacterium tuberculosis | Possible exported protein | 0.1086 | 0.1155 | 0.1148 |
Mycobacterium ulcerans | peptide deformylase | 0.8386 | 1 | 1 |
Brugia malayi | Matrixin family protein | 0.0276 | 0.0174 | 1 |
Trypanosoma brucei | Polypeptide deformylase 1 | 0.32 | 0.3716 | 0.5 |
Plasmodium vivax | peptide deformylase, putative | 0.8386 | 1 | 0.5 |
Trypanosoma cruzi | Peptide deformylase 2, putative | 0.32 | 0.3716 | 0.5 |
Loa Loa (eye worm) | matrixin family protein | 0.0276 | 0.0174 | 0.4483 |
Onchocerca volvulus | Matrix metalloproteinase homolog | 0.0253 | 0.0146 | 1 |
Trypanosoma cruzi | polypeptide deformylase-like protein, putative | 0.32 | 0.3716 | 0.5 |
Treponema pallidum | polypeptide deformylase (def) | 0.8386 | 1 | 0.5 |
Echinococcus granulosus | matrix metallopeptidase 7 M10 family | 0.0415 | 0.0342 | 1 |
Brugia malayi | Hemopexin family protein | 0.0162 | 0.0035 | 0.1666 |
Schistosoma mansoni | ADAM17 peptidase (M12 family) | 0.0212 | 0.0096 | 1 |
Plasmodium falciparum | peptide deformylase | 0.8386 | 1 | 0.5 |
Mycobacterium leprae | PROBABLE POLYPEPTIDE DEFORMYLASE DEF (PDF) (FORMYLMETHIONINE DEFORMYLASE) | 0.8386 | 1 | 1 |
Mycobacterium tuberculosis | Probable polypeptide deformylase Def (PDF) (formylmethionine deformylase) | 0.8386 | 1 | 1 |
Echinococcus granulosus | adam 17 protease | 0.0233 | 0.0121 | 0.3539 |
Loa Loa (eye worm) | matrixin family protein | 0.0253 | 0.0146 | 0.3736 |
Trypanosoma cruzi | Peptide deformylase 2, putative | 0.32 | 0.3716 | 0.5 |
Toxoplasma gondii | hypothetical protein | 0.8386 | 1 | 0.5 |
Wolbachia endosymbiont of Brugia malayi | peptide deformylase | 0.8386 | 1 | 0.5 |
Leishmania major | polypeptide deformylase-like protein, putative | 0.32 | 0.3716 | 0.5 |
Trypanosoma cruzi | polypeptide deformylase-like protein, putative | 0.32 | 0.3716 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0445 | 0.0378 | 1 |
Echinococcus multilocularis | matrix metallopeptidase 7 (M10 family) | 0.0415 | 0.0342 | 1 |
Onchocerca volvulus | Matrilysin homolog | 0.0253 | 0.0146 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Kb app (binding) | = 1 uM | Ability to inhibit Endothelin A receptor induced contractions in rabbit carotid artery rings (ETA) was determined in an in vitro functional assay. | ChEMBL. | 9857090 |
Kb app (binding) | = 1 uM | Ability to inhibit Endothelin A receptor induced contractions in rabbit carotid artery rings (ETA) was determined in an in vitro functional assay. | ChEMBL. | 9857090 |
Ki (binding) | = 0.19 uM | Ability of the compound to inhibit binding of [125I]-ET-1 to membranes prepared from A10 rat thoracic aorta smooth muscle Endothelin A receptor | ChEMBL. | 9857090 |
Ki (binding) | = 0.19 uM | Ability of the compound to inhibit binding of [125I]-ET-1 to membranes prepared from A10 rat thoracic aorta smooth muscle Endothelin A receptor | ChEMBL. | 9857090 |
Ki (binding) | = 5.6 uM | Ability to inhibit binding of [125I]-ET-1 to membranes prepared from A10 rat cerebellum (Endothelin B receptor) | ChEMBL. | 9857090 |
Ki (binding) | = 5.6 uM | Ability to inhibit binding of [125I]-ET-1 to membranes prepared from A10 rat cerebellum (Endothelin B receptor) | ChEMBL. | 9857090 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.