Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Onchocerca volvulus | 0.0091 | 0.1964 | 0.2332 | |
Onchocerca volvulus | 0.0048 | 0.0487 | 0.0539 | |
Loa Loa (eye worm) | glycosyl hydrolase family 31 protein | 0.0035 | 0.0049 | 0.0007 |
Brugia malayi | inosine-5'-monophosphate dehydrogenase | 0.0066 | 0.1095 | 0.1482 |
Loa Loa (eye worm) | IMP dehydrogenase 1 | 0.0158 | 0.4243 | 0.5922 |
Brugia malayi | RNA binding protein | 0.0061 | 0.0945 | 0.1272 |
Schistosoma mansoni | alpha-glucosidase | 0.0136 | 0.3481 | 0.7137 |
Schistosoma mansoni | cellular tumor antigen P53 | 0.0048 | 0.0487 | 0.0921 |
Plasmodium vivax | inosine-5'-monophosphate dehydrogenase, putative | 0.0149 | 0.3923 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0159 | 0.4264 | 0.5951 |
Echinococcus granulosus | tar DNA binding protein | 0.0061 | 0.0945 | 0.0945 |
Mycobacterium leprae | Probable inosine-5'-monophosphate dehydrogenase GuaB2 (IMP dehydrogenase) (IMPDH) (IMPD) | 0.0158 | 0.4243 | 1 |
Loa Loa (eye worm) | RNA binding protein | 0.0061 | 0.0945 | 0.1272 |
Toxoplasma gondii | glycosyl hydrolase, family 31 protein | 0.0035 | 0.0049 | 0.0012 |
Loa Loa (eye worm) | follicle stimulating hormone receptor | 0.0224 | 0.6495 | 0.9097 |
Trypanosoma brucei | GMP reductase | 0.0158 | 0.4243 | 1 |
Echinococcus multilocularis | tar DNA binding protein | 0.0061 | 0.0945 | 0.0906 |
Entamoeba histolytica | glycosyl hydrolase, family 31 protein | 0.0035 | 0.0049 | 0.5 |
Trypanosoma brucei | inosine-5'-monophosphate dehydrogenase | 0.0158 | 0.4243 | 1 |
Echinococcus granulosus | histone lysine methyltransferase setb | 0.0035 | 0.0044 | 0.0044 |
Echinococcus multilocularis | tumor protein p63 | 0.0327 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.004 | 0.0212 | 0.0237 |
Schistosoma mansoni | tar DNA-binding protein | 0.0061 | 0.0945 | 0.1872 |
Onchocerca volvulus | 0.0277 | 0.8279 | 1 | |
Echinococcus granulosus | lysosomal alpha glucosidase | 0.0158 | 0.4229 | 0.4229 |
Brugia malayi | follicle stimulating hormone receptor | 0.0224 | 0.6495 | 0.9097 |
Echinococcus granulosus | muscleblind protein | 0.0159 | 0.4264 | 0.4264 |
Leishmania major | guanosine monophosphate reductase | 0.0158 | 0.4243 | 1 |
Echinococcus multilocularis | lysosomal alpha glucosidase | 0.0158 | 0.4229 | 0.4204 |
Brugia malayi | TAR-binding protein | 0.0061 | 0.0945 | 0.1272 |
Schistosoma mansoni | tar DNA-binding protein | 0.0061 | 0.0945 | 0.1872 |
Trypanosoma cruzi | inosine-5'-monophosphate dehydrogenase, putative | 0.0158 | 0.4243 | 1 |
Schistosoma mansoni | alpha-glucosidase | 0.0136 | 0.3481 | 0.7137 |
Mycobacterium ulcerans | inosine 5'-monophosphate dehydrogenase | 0.0158 | 0.4243 | 1 |
Echinococcus multilocularis | geminin | 0.0176 | 0.486 | 0.4838 |
Echinococcus granulosus | inosine 5' monophosphate dehydrogenase 2 | 0.0158 | 0.4243 | 0.4243 |
Echinococcus granulosus | geminin | 0.0176 | 0.486 | 0.486 |
Trichomonas vaginalis | set domain proteins, putative | 0.0277 | 0.8279 | 1 |
Brugia malayi | Pre-SET motif family protein | 0.0243 | 0.7135 | 1 |
Loa Loa (eye worm) | pre-SET domain-containing protein family protein | 0.0243 | 0.7135 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0061 | 0.0945 | 0.1872 |
Loa Loa (eye worm) | hypothetical protein | 0.0159 | 0.4264 | 0.5951 |
Trypanosoma cruzi | inosine-5'-monophosphate dehydrogenase, putative | 0.0158 | 0.4243 | 1 |
Loa Loa (eye worm) | glycosyl hydrolase family 31 protein | 0.0158 | 0.4229 | 0.5903 |
Schistosoma mansoni | hypothetical protein | 0.0176 | 0.486 | 1 |
Schistosoma mansoni | inosine-5-monophosphate dehydrogenase | 0.0158 | 0.4243 | 0.8719 |
Loa Loa (eye worm) | GMP reductase | 0.0066 | 0.1095 | 0.1482 |
Brugia malayi | inosine-5'-monophosphate dehydrogenase | 0.0066 | 0.1095 | 0.1482 |
Mycobacterium ulcerans | inosine 5-monophosphate dehydrogenase | 0.0149 | 0.3923 | 0.8869 |
Brugia malayi | inosine-5'-monophosphate dehydrogenase family protein | 0.0158 | 0.4243 | 0.5922 |
Schistosoma mansoni | tar DNA-binding protein | 0.0061 | 0.0945 | 0.1872 |
Mycobacterium leprae | Probable inosine-5'-monophosphate dehydrogenase GuaB3 (IMP dehydrogenase 2) (inosinic acid dehydrogenase) (inosinate dehydrogena | 0.0083 | 0.1685 | 0.0954 |
Loa Loa (eye worm) | TAR-binding protein | 0.0061 | 0.0945 | 0.1272 |
Brugia malayi | Glycosyl hydrolases family 31 protein | 0.0035 | 0.0049 | 0.0007 |
Echinococcus multilocularis | neutral alpha glucosidase AB | 0.0035 | 0.0049 | 0.0005 |
Schistosoma mansoni | tar DNA-binding protein | 0.0061 | 0.0945 | 0.1872 |
Brugia malayi | Muscleblind-like protein | 0.0159 | 0.4264 | 0.5951 |
Trypanosoma cruzi | inosine-5'-monophosphate dehydrogenase, putative | 0.0158 | 0.4243 | 1 |
Mycobacterium tuberculosis | Probable inosine-5'-monophosphate dehydrogenase GuaB2 (imp dehydrogenase) (inosinic acid dehydrogenase) (inosinate dehydrogenase | 0.0158 | 0.4243 | 1 |
Leishmania major | inosine-5-monophosphate dehydrogenase | 0.0158 | 0.4243 | 1 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0061 | 0.0945 | 0.1272 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0058 | 0.0839 | 0.1122 |
Schistosoma mansoni | hypothetical protein | 0.0176 | 0.486 | 1 |
Trypanosoma cruzi | GMP reductase | 0.0158 | 0.4243 | 1 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0058 | 0.0839 | 0.1122 |
Echinococcus multilocularis | muscleblind protein | 0.0159 | 0.4264 | 0.4239 |
Schistosoma mansoni | alpha glucosidase | 0.0035 | 0.0049 | 0.001 |
Trypanosoma cruzi | GMP reductase | 0.0158 | 0.4243 | 1 |
Echinococcus multilocularis | lysosomal alpha glucosidase | 0.0158 | 0.4229 | 0.4204 |
Echinococcus granulosus | neutral alpha glucosidase AB | 0.0035 | 0.0049 | 0.0049 |
Wolbachia endosymbiont of Brugia malayi | IMP dehydrogenase | 0.0158 | 0.4243 | 0.5 |
Brugia malayi | GMP reductase | 0.0066 | 0.1095 | 0.1482 |
Toxoplasma gondii | IMP dehydrogenas | 0.0158 | 0.4243 | 1 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0058 | 0.0839 | 0.1122 |
Echinococcus multilocularis | inosine 5' monophosphate dehydrogenase 2 | 0.0158 | 0.4243 | 0.4218 |
Echinococcus multilocularis | muscleblind protein 1 | 0.0159 | 0.4264 | 0.4239 |
Onchocerca volvulus | Putative GMP reductase | 0.0066 | 0.1095 | 0.1276 |
Brugia malayi | Glycosyl hydrolases family 31 protein | 0.0158 | 0.4229 | 0.5903 |
Schistosoma mansoni | hypothetical protein | 0.004 | 0.0212 | 0.0349 |
Entamoeba histolytica | glycosyl hydrolase, family 31 protein | 0.0035 | 0.0049 | 0.5 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.004 | 0.0212 | 0.0237 |
Loa Loa (eye worm) | hypothetical protein | 0.0058 | 0.0839 | 0.1122 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0061 | 0.0945 | 0.1272 |
Loa Loa (eye worm) | hypothetical protein | 0.0048 | 0.0487 | 0.0626 |
Plasmodium falciparum | inosine-5'-monophosphate dehydrogenase | 0.0149 | 0.3923 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Delta BG (functional) | = -36 % | Maximum % decrease of blood glucose (deltaBG) was observed within 4 hour after administration orally at 10 mg/kg dose to fasted adult female rats versus a control group | ChEMBL. | 9857091 |
Delta BG (functional) | = -18 % | Maximum % decrease of blood glucose (deltaBG) of the compound was observed within 4 hour after administration orally at 5 mg/kg dose to fasted adult female rats versus a control group | ChEMBL. | 9857091 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.