Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | Telomerase reverse transcriptase | 0.0982 | 0.7228 | 1 |
Echinococcus multilocularis | thyroid hormone receptor alpha | 0.0146 | 0.0947 | 0.3649 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0039 | 0.0141 | 0.0503 |
Plasmodium falciparum | telomerase reverse transcriptase | 0.0369 | 0.2623 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0097 | 0.0581 | 0.6552 |
Loa Loa (eye worm) | hypothetical protein | 0.0053 | 0.025 | 0.2817 |
Trypanosoma cruzi | telomerase reverse transcriptase, putative | 0.0369 | 0.2623 | 0.5 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0039 | 0.0141 | 0.0824 |
Loa Loa (eye worm) | follicle stimulating hormone receptor | 0.0138 | 0.0887 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0039 | 0.0141 | 0.5 |
Entamoeba histolytica | hypothetical protein | 0.0039 | 0.0141 | 0.5 |
Loa Loa (eye worm) | hypoxia-induced factor 1 | 0.009 | 0.0525 | 0.5914 |
Schistosoma mansoni | thyroid hormone receptor | 0.0146 | 0.0947 | 1 |
Mycobacterium ulcerans | putative regulatory protein | 0.0021 | 0.0012 | 0.5 |
Schistosoma mansoni | cellular tumor antigen P53 | 0.0053 | 0.025 | 0.2061 |
Echinococcus granulosus | tumor protein p63 | 0.0362 | 0.2574 | 1 |
Brugia malayi | hypothetical protein | 0.0097 | 0.0581 | 0.0804 |
Leishmania major | telomerase reverse transcriptase, putative | 0.0369 | 0.2623 | 0.5 |
Toxoplasma gondii | RNA-directed DNA polymerase | 0.0369 | 0.2623 | 0.5 |
Giardia lamblia | Telomerase catalytic subunit | 0.0369 | 0.2623 | 0.5 |
Plasmodium vivax | telomerase reverse transcriptase, putative | 0.0369 | 0.2623 | 0.5 |
Brugia malayi | follicle stimulating hormone receptor | 0.0138 | 0.0887 | 0.1227 |
Brugia malayi | hypoxia-induced factor 1 | 0.009 | 0.0525 | 0.0726 |
Echinococcus granulosus | Mitotic checkpoint protein PRCC C terminal | 0.0135 | 0.0866 | 0.3331 |
Onchocerca volvulus | 0.0053 | 0.025 | 0.0238 | |
Echinococcus multilocularis | tumor protein p63 | 0.0362 | 0.2574 | 1 |
Echinococcus multilocularis | Mitotic checkpoint protein PRCC, C terminal | 0.0135 | 0.0866 | 0.3331 |
Schistosoma mansoni | hypothetical protein | 0.0135 | 0.0866 | 0.9073 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0039 | 0.0141 | 0.0503 |
Trypanosoma cruzi | telomerase reverse transcriptase, putative | 0.0369 | 0.2623 | 0.5 |
Brugia malayi | bHLH-PAS transcription factor | 0.0021 | 0.0012 | 0.0017 |
Schistosoma mansoni | thyroid hormone receptor | 0.0146 | 0.0947 | 1 |
Brugia malayi | PAS domain containing protein | 0.0029 | 0.0069 | 0.0095 |
Entamoeba histolytica | hypothetical protein | 0.0039 | 0.0141 | 0.5 |
Entamoeba histolytica | hypothetical protein | 0.0039 | 0.0141 | 0.5 |
Brugia malayi | hypothetical protein | 0.0039 | 0.0141 | 0.0195 |
Trypanosoma brucei | telomerase reverse transcriptase | 0.0369 | 0.2623 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0039 | 0.0141 | 0.0824 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Relative ED50 (functional) | Thyromimetic activity (induction of GPDH) in rat liver expressed as percentage of ratio of the ED50 for T3; LM= Low maximum response | ChEMBL. | 3336030 | |
Relative ED50 (functional) | Thyromimetic activity (induction of GPDH) in rat heart expressed as percentage of ratio of the ED50 for T3; LM= Low maximum response | ChEMBL. | 3336030 | |
Relative ED50 (functional) | 0 | Thyromimetic activity (induction of GPDH) in rat liver expressed as percentage of ratio of the ED50 for T3; LM= Low maximum response | ChEMBL. | 3336030 |
Relative ED50 (functional) | 0 | Thyromimetic activity (induction of GPDH) in rat heart expressed as percentage of ratio of the ED50 for T3; LM= Low maximum response | ChEMBL. | 3336030 |
Relative IC50 (binding) | = 0.03 | Relative binding affinity for T3 thyroid hormone nuclear receptor in rat liver, expressed as percent ratio of IC50 comapred to T3 | ChEMBL. | 3336030 |
Relative IC50 (binding) | = 0.1 | Relative binding affinity towards T3 nuclear receptor in rat heart, expressed as percent ratio of IC50 for T3 to that of compound | ChEMBL. | 3336030 |
Relative IC50 (binding) | = 0.03 | Relative binding affinity for T3 thyroid hormone nuclear receptor in rat liver, expressed as percent ratio of IC50 comapred to T3 | ChEMBL. | 3336030 |
Relative IC50 (binding) | = 0.1 | Relative binding affinity towards T3 nuclear receptor in rat heart, expressed as percent ratio of IC50 for T3 to that of compound | ChEMBL. | 3336030 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.