Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | hypothetical protein | 0.0025 | 0.1898 | 0.1898 |
Loa Loa (eye worm) | TAR-binding protein | 0.0063 | 1 | 1 |
Leishmania major | hypothetical protein, conserved | 0.0025 | 0.1898 | 0.5 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0046 | 0.626 | 0.5384 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0025 | 0.1898 | 0.5 |
Plasmodium vivax | ataxin-2 like protein, putative | 0.0025 | 0.1898 | 0.5 |
Schistosoma mansoni | tar DNA-binding protein | 0.0063 | 1 | 1 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0063 | 1 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0063 | 1 | 1 |
Toxoplasma gondii | LsmAD domain-containing protein | 0.0025 | 0.1898 | 0.5 |
Schistosoma mansoni | tar DNA-binding protein | 0.0063 | 1 | 1 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0025 | 0.1898 | 0.5 |
Echinococcus multilocularis | tar DNA binding protein | 0.0063 | 1 | 1 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0025 | 0.1898 | 0.5 |
Brugia malayi | TAR-binding protein | 0.0063 | 1 | 1 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0063 | 1 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0063 | 1 | 1 |
Echinococcus granulosus | tar DNA binding protein | 0.0063 | 1 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0063 | 1 | 1 |
Trypanosoma brucei | PAB1-binding protein , putative | 0.0025 | 0.1898 | 0.5 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0025 | 0.1898 | 0.5 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0046 | 0.626 | 0.626 |
Loa Loa (eye worm) | RNA binding protein | 0.0063 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
TCS50 (functional) | = 0.19 uM | Tested for cytotoxicity of the compound against human promyelocytic leukemia K562 cell line | ChEMBL. | 14640549 |
TCS50 (functional) | = 0.19 uM | Tested for cytotoxicity of the compound against human promyelocytic leukemia K562 cell line | ChEMBL. | 14640549 |
TCS50 (functional) | = 0.28 uM | Tested for cytotoxicity of the compound against human promyelocytic leukemia K562-CdA cell line | ChEMBL. | 14640549 |
TCS50 (functional) | = 0.28 uM | Tested for cytotoxicity of the compound against human promyelocytic leukemia K562-CdA cell line | ChEMBL. | 14640549 |
TCS50 (functional) | = 0.35 uM | Tested for cytotoxicity of the compound against human promyelocytic leukemia K562-FLU D-CEM cell line | ChEMBL. | 14640549 |
TCS50 (functional) | = 0.35 uM | Tested for cytotoxicity of the compound against human promyelocytic leukemia K562-FLU D-CEM cell line | ChEMBL. | 14640549 |
TCS50 (functional) | = 0.43 uM | Tested for cytotoxicity of the compound against mouse melanoma B16 cell line | ChEMBL. | 14640549 |
TCS50 (functional) | = 0.43 uM | Tested for cytotoxicity of the compound against mouse melanoma B16 cell line | ChEMBL. | 14640549 |
TCS50 (functional) | = 0.61 uM | Tested for cytotoxicity of the compound against human T-lymphoblastic leukemia CEM-DNR 1/C2 cell line | ChEMBL. | 14640549 |
TCS50 (functional) | = 0.61 uM | Tested for cytotoxicity of the compound against human T-lymphoblastic leukemia CEM-DNR 1/C2 cell line | ChEMBL. | 14640549 |
TCS50 (functional) | = 0.63 uM | Tested for cytotoxicity of the compound against human promyelocytic leukemia K562-ARA-C cell line | ChEMBL. | 14640549 |
TCS50 (functional) | = 0.63 uM | Tested for cytotoxicity of the compound against human promyelocytic leukemia K562-ARA-C cell line | ChEMBL. | 14640549 |
TCS50 (functional) | = 0.84 uM | Tested for cytotoxicity of the compound against human prostrate cancer DU145 cell line | ChEMBL. | 14640549 |
TCS50 (functional) | = 0.84 uM | Tested for cytotoxicity of the compound against human prostrate cancer DU145 cell line | ChEMBL. | 14640549 |
TCS50 (functional) | = 0.9 uM | Tested for cytotoxicity of the compound against human ovarian cancer OVCAR-3 cell line | ChEMBL. | 14640549 |
TCS50 (functional) | = 0.9 uM | Tested for cytotoxicity of the compound against human ovarian cancer OVCAR-3 cell line | ChEMBL. | 14640549 |
TCS50 (functional) | = 0.94 uM | Tested for cytotoxicity of the compound against human promyelocytic leukemia K562-GEM cell line | ChEMBL. | 14640549 |
TCS50 (functional) | = 0.94 uM | Tested for cytotoxicity of the compound against human promyelocytic leukemia K562-GEM cell line | ChEMBL. | 14640549 |
TCS50 (functional) | = 1 uM | Cytotoxicity against chemosensitive CEM-T lymphoblastc leukaemia cell line. | ChEMBL. | 14640549 |
TCS50 (functional) | = 1 uM | Tested for cytotoxicity of the compound against human T-lymphoblastic leukemia CEM cell line | ChEMBL. | 14640549 |
TCS50 (functional) | = 1 uM | Cytotoxicity against chemosensitive CEM-T lymphoblastc leukaemia cell line. | ChEMBL. | 14640549 |
TCS50 (functional) | = 1 uM | Tested for cytotoxicity of the compound against human T-lymphoblastic leukemia CEM cell line | ChEMBL. | 14640549 |
TCS50 (functional) | = 1.05 uM | Tested for cytotoxicity of the compound against human T-lymphoblastic leukemia CEM-DNR bulk cell line | ChEMBL. | 14640549 |
TCS50 (functional) | = 1.05 uM | Tested for cytotoxicity of the compound against human T-lymphoblastic leukemia CEM-DNR bulk cell line | ChEMBL. | 14640549 |
TCS50 (functional) | = 1.12 uM | Tested for cytotoxicity of the compound against human prostrate cancer LNCaP cell line | ChEMBL. | 14640549 |
TCS50 (functional) | = 1.12 uM | Tested for cytotoxicity of the compound against human prostrate cancer LNCaP cell line | ChEMBL. | 14640549 |
TCS50 (functional) | = 1.22 uM | Tested for cytotoxicity of the compound against human colon cancer SW620 cell line | ChEMBL. | 14640549 |
TCS50 (functional) | = 1.22 uM | Tested for cytotoxicity of the compound against human colon cancer SW620 cell line | ChEMBL. | 14640549 |
TCS50 (functional) | = 1.28 uM | Tested for cytotoxicity of the compound against human melanoma MEL-3 celll line | ChEMBL. | 14640549 |
TCS50 (functional) | = 1.28 uM | Tested for cytotoxicity of the compound against human melanoma MEL-3 celll line | ChEMBL. | 14640549 |
TCS50 (functional) | = 1.35 uM | Tested for cytotoxicity of the compound against human breast cancer MDA-MB-238 cell line | ChEMBL. | 14640549 |
TCS50 (functional) | = 1.35 uM | Tested for cytotoxicity of the compound against human breast cancer MDA-MB-238 cell line | ChEMBL. | 14640549 |
TCS50 (functional) | = 1.53 uM | Tested for cytotoxicity of the compound against human osteosarcoma U2OS cell line | ChEMBL. | 14640549 |
TCS50 (functional) | = 1.53 uM | Tested for cytotoxicity of the compound against human osteosarcoma U2OS cell line | ChEMBL. | 14640549 |
TCS50 (functional) | = 1.67 uM | Tested for cytotoxicity of the compound against human hepatocellular carcinoma HepG2 cell line | ChEMBL. | 14640549 |
TCS50 (functional) | = 1.67 uM | Tested for cytotoxicity of the compound against human hepatocellular carcinoma HepG2 cell line | ChEMBL. | 14640549 |
TCS50 (functional) | = 1.78 uM | Tested for cytotoxicity of the compound against human rhabdomyosarcoma Saos2 cell line | ChEMBL. | 14640549 |
TCS50 (functional) | = 1.78 uM | Tested for cytotoxicity of the compound against human rhabdomyosarcoma Saos2 cell line | ChEMBL. | 14640549 |
TCS50 (functional) | = 1.85 uM | Tested for cytotoxicity of the compound against human glioblastoma U87MG cell line | ChEMBL. | 14640549 |
TCS50 (functional) | = 1.85 uM | Tested for cytotoxicity of the compound against human glioblastoma U87MG cell line | ChEMBL. | 14640549 |
TCS50 (functional) | = 2.03 uM | Tested for cytotoxicity of the compound against human breast cancer BT549 cell line | ChEMBL. | 14640549 |
TCS50 (functional) | = 2.03 uM | Tested for cytotoxicity of the compound against human breast cancer BT549 cell line | ChEMBL. | 14640549 |
TCS50 (functional) | = 2.3 uM | Tested for cytotoxicity of the compound against human breast cancer MCF-7 cell line | ChEMBL. | 14640549 |
TCS50 (functional) | = 2.3 uM | Tested for cytotoxicity of the compound against human breast cancer MCF-7 cell line | ChEMBL. | 14640549 |
TCS50 (functional) | = 2.51 uM | Tested for cytotoxicity of the compound against human T-lymphoblastic leukemia CEM-VCR bulk cell line | ChEMBL. | 14640549 |
TCS50 (functional) | = 2.51 uM | Tested for cytotoxicity of the compound against human T-lymphoblastic leukemia CEM-VCR bulk cell line | ChEMBL. | 14640549 |
TCS50 (functional) | = 2.8 uM | Tested for cytotoxicity of the compound against human lung adenocarcinoma A549 cell line | ChEMBL. | 14640549 |
TCS50 (functional) | = 2.8 uM | Tested for cytotoxicity of the compound against human lung adenocarcinoma A549 cell line | ChEMBL. | 14640549 |
TCS50 (functional) | = 2.93 uM | Tested for cytotoxicity of the compound against human T-lymphoblastic leukemia CEM-VCR 1/D5 cell line | ChEMBL. | 14640549 |
TCS50 (functional) | = 2.93 uM | Tested for cytotoxicity of the compound against human T-lymphoblastic leukemia CEM-VCR 1/D5 cell line | ChEMBL. | 14640549 |
TCS50 (functional) | = 2.97 uM | Tested for cytotoxicity of the compound against human colon cancer Caco-2 cell line | ChEMBL. | 14640549 |
TCS50 (functional) | = 2.97 uM | Tested for cytotoxicity of the compound against human colon cancer Caco-2 cell line | ChEMBL. | 14640549 |
TCS50 (functional) | = 3.27 uM | Tested for cytotoxicity of the compound against human T-lymphoblastic leukemia CEM-VCR 1/F3 cell line | ChEMBL. | 14640549 |
TCS50 (functional) | = 3.27 uM | Tested for cytotoxicity of the compound against human T-lymphoblastic leukemia CEM-VCR 1/F3 cell line | ChEMBL. | 14640549 |
TCS50 (functional) | = 3.57 uM | Tested for cytotoxicity of the compound against human colon cancer HT-29 cell line | ChEMBL. | 14640549 |
TCS50 (functional) | = 3.57 uM | Tested for cytotoxicity of the compound against human colon cancer HT-29 cell line | ChEMBL. | 14640549 |
TCS50 (functional) | = 4.66 uM | Tested for cytotoxicity of the compound against mouse melanoma B16F cell line | ChEMBL. | 14640549 |
TCS50 (functional) | = 4.66 uM | Tested for cytotoxicity of the compound against mouse melanoma B16F cell line | ChEMBL. | 14640549 |
TCS50 (functional) | = 7.21 uM | Tested for cytotoxicity of the compound against mouse immortalized fibroblast NIH3T3 cell line | ChEMBL. | 14640549 |
TCS50 (functional) | = 7.21 uM | Tested for cytotoxicity of the compound against mouse immortalized fibroblast NIH3T3 cell line | ChEMBL. | 14640549 |
TCS50 (functional) | = 12.5 uM | Tested for cytotoxicity of the compound against human normal lymphocytes | ChEMBL. | 14640549 |
TCS50 (functional) | = 12.5 uM | Tested for cytotoxicity of the compound against human normal lymphocytes | ChEMBL. | 14640549 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.