Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Onchocerca volvulus | 0.2648 | 1 | 1 | |
Loa Loa (eye worm) | hypothetical protein | 0.2648 | 1 | 1 |
Brugia malayi | LBP / BPI / CETP family, N-terminal domain containing protein | 0.2648 | 1 | 1 |
Loa Loa (eye worm) | LBP/BPI/CETP family domain-containing protein | 0.2648 | 1 | 1 |
Onchocerca volvulus | 0.2648 | 1 | 1 | |
Brugia malayi | LBP / BPI / CETP family, C-terminal domain containing protein | 0.2648 | 1 | 1 |
Onchocerca volvulus | 0.2648 | 1 | 1 | |
Onchocerca volvulus | 0.2648 | 1 | 1 | |
Onchocerca volvulus | 0.2648 | 1 | 1 | |
Onchocerca volvulus | 0.2648 | 1 | 1 | |
Onchocerca volvulus | 0.2648 | 1 | 1 | |
Onchocerca volvulus | 0.2648 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
MEC (functional) | = 10 uM | Minimum effective concentration required for more than 1 IU/mL induction of IFN using mice spleen cells | ChEMBL. | 12459008 |
MEC (functional) | = 10 uM | Minimum effective concentration required for more than 1 IU/mL induction of IFN using mice spleen cells | ChEMBL. | 12459008 |
MED (functional) | = 30 mg kg-1 | Minimum effective dose required for more than 100 IU/mL induction of IFN using mice after peroral administration. | ChEMBL. | 12459008 |
MED (functional) | = 30 mg kg-1 | Minimum effective dose required for more than 100 IU/mL induction of IFN using mice after peroral administration. | ChEMBL. | 12459008 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.