Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Onchocerca volvulus | 0.3413 | 1 | 1 | |
Onchocerca volvulus | 0.3413 | 1 | 1 | |
Onchocerca volvulus | 0.3413 | 1 | 1 | |
Onchocerca volvulus | 0.3413 | 1 | 1 | |
Onchocerca volvulus | 0.3413 | 1 | 1 | |
Onchocerca volvulus | 0.3413 | 1 | 1 | |
Brugia malayi | LBP / BPI / CETP family, C-terminal domain containing protein | 0.3413 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.3413 | 1 | 1 |
Onchocerca volvulus | 0.3413 | 1 | 1 | |
Brugia malayi | LBP / BPI / CETP family, N-terminal domain containing protein | 0.3413 | 1 | 1 |
Loa Loa (eye worm) | LBP/BPI/CETP family domain-containing protein | 0.3413 | 1 | 1 |
Onchocerca volvulus | 0.3413 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
ED50 (functional) | = 1.7 mg kg-1 | Serotonergic activity of the compound was determined by measuring the potentiation of 5-hydroxy tryptophan in mice upon ip administration; value ranges from 1.4-2.1 | ChEMBL. | 2563772 |
ED50 (functional) | = 1.7 mg kg-1 | Serotonergic activity of the compound was determined by measuring the potentiation of 5-hydroxy tryptophan in mice upon ip administration; value ranges from 1.4-2.1 | ChEMBL. | 2563772 |
ED50 (functional) | = 10 mg kg-1 | Compound was tested for antidepressant activity against reserpine induced ptosis in mice after intraperitoneal administration.; value ranges from 9-12 | ChEMBL. | 2563772 |
ED50 (functional) | = 10 mg kg-1 | Compound was tested for antidepressant activity against reserpine induced ptosis in mice after intraperitoneal administration.; value ranges from 9-12 | ChEMBL. | 2563772 |
LD50 (ADMET) | = 72 mg kg-1 | Acute toxicity in mice after intraperitoneal administration. | ChEMBL. | 2563772 |
LD50 (ADMET) | = 72 mg kg-1 | Acute toxicity in mice after intraperitoneal administration. | ChEMBL. | 2563772 |
MED (functional) | > 10 mg kg-1 | Ability of the compound to modify turning behavior of mice after intraperitoneal administration | ChEMBL. | 2563772 |
MED (functional) | > 10 mg kg-1 | Ability of the compound to modify turning behavior of mice after intraperitoneal administration | ChEMBL. | 2563772 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.