Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | glutamate receptor, ionotropic, N-methyl D-aspartate 2B | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Echinococcus multilocularis | glutamate (NMDA) receptor subunit | Get druggable targets OG5_129290 | All targets in OG5_129290 |
Echinococcus granulosus | glutamate NMDA receptor subunit | Get druggable targets OG5_129290 | All targets in OG5_129290 |
Schistosoma japonicum | ko:K05314 glutamate receptor, ionotropic, N-methyl-D-aspartate 2, invertebrate, putative | Get druggable targets OG5_129290 | All targets in OG5_129290 |
Schistosoma mansoni | glutamate receptor NMDA | Get druggable targets OG5_129290 | All targets in OG5_129290 |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | glutamate NMDA receptor subunit | 0.0091 | 0.0487 | 1 |
Onchocerca volvulus | 0.1304 | 1 | 1 | |
Brugia malayi | LBP / BPI / CETP family, C-terminal domain containing protein | 0.0748 | 0.5636 | 0.2556 |
Schistosoma mansoni | glutamate receptor NMDA | 0.0091 | 0.0487 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0748 | 0.5636 | 0.2556 |
Onchocerca volvulus | 0.1304 | 1 | 1 | |
Loa Loa (eye worm) | LBP/BPI/CETP family domain-containing protein | 0.1304 | 1 | 1 |
Brugia malayi | LBP / BPI / CETP family, C-terminal domain containing protein | 0.0748 | 0.5636 | 0.2556 |
Onchocerca volvulus | 0.1304 | 1 | 1 | |
Onchocerca volvulus | 0.1304 | 1 | 1 | |
Onchocerca volvulus | 0.1304 | 1 | 1 | |
Brugia malayi | LBP / BPI / CETP family, N-terminal domain containing protein | 0.1304 | 1 | 1 |
Brugia malayi | hypothetical protein | 0.0748 | 0.5636 | 0.2556 |
Brugia malayi | LBP / BPI / CETP family, C-terminal domain containing protein | 0.1304 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0748 | 0.5636 | 0.2556 |
Loa Loa (eye worm) | hypothetical protein | 0.0748 | 0.5636 | 0.2556 |
Onchocerca volvulus | 0.1304 | 1 | 1 | |
Onchocerca volvulus | 0.0748 | 0.5636 | 0.2556 | |
Brugia malayi | LBP / BPI / CETP family, C-terminal domain containing protein | 0.0748 | 0.5636 | 0.2556 |
Onchocerca volvulus | 0.1304 | 1 | 1 | |
Trichomonas vaginalis | conserved hypothetical protein | 0.0557 | 0.4138 | 0.5 |
Onchocerca volvulus | 0.0748 | 0.5636 | 0.2556 | |
Echinococcus multilocularis | glutamate (NMDA) receptor subunit | 0.0091 | 0.0487 | 1 |
Loa Loa (eye worm) | LBP/BPI/CETP family domain-containing protein | 0.0748 | 0.5636 | 0.2556 |
Loa Loa (eye worm) | hypothetical protein | 0.0748 | 0.5636 | 0.2556 |
Brugia malayi | hypothetical protein | 0.0748 | 0.5636 | 0.2556 |
Loa Loa (eye worm) | hypothetical protein | 0.0748 | 0.5636 | 0.2556 |
Loa Loa (eye worm) | hypothetical protein | 0.1304 | 1 | 1 |
Loa Loa (eye worm) | LBP/BPI/CETP family domain-containing protein | 0.0748 | 0.5636 | 0.2556 |
Onchocerca volvulus | 0.1304 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | = 7.4 uM | Antagonistic activity against NR1A/2B receptor in frog oocytes | ChEMBL. | 10741546 |
IC50 (functional) | = 7.4 uM | Antagonistic activity against NR1A/2B receptor in frog oocytes | ChEMBL. | 10741546 |
IC50 (functional) | > 100 uM | Antagonistic activity against NR1A/2A receptors in frog oocytes | ChEMBL. | 10741546 |
IC50 (functional) | > 100 uM | Antagonistic activity against NR1A/2C receptor in frog oocytes | ChEMBL. | 10741546 |
IC50 (functional) | > 100 uM | Antagonistic activity against NR1A/2A receptors in frog oocytes | ChEMBL. | 10741546 |
IC50 (functional) | > 100 uM | Antagonistic activity against NR1A/2C receptor in frog oocytes | ChEMBL. | 10741546 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.