Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | LBP / BPI / CETP family, N-terminal domain containing protein | 0.3094 | 1 | 1 |
Loa Loa (eye worm) | LBP/BPI/CETP family domain-containing protein | 0.3094 | 1 | 1 |
Onchocerca volvulus | 0.3094 | 1 | 1 | |
Loa Loa (eye worm) | hypothetical protein | 0.3094 | 1 | 1 |
Onchocerca volvulus | 0.3094 | 1 | 1 | |
Onchocerca volvulus | 0.3094 | 1 | 1 | |
Onchocerca volvulus | 0.3094 | 1 | 1 | |
Onchocerca volvulus | 0.3094 | 1 | 1 | |
Onchocerca volvulus | 0.3094 | 1 | 1 | |
Onchocerca volvulus | 0.3094 | 1 | 1 | |
Onchocerca volvulus | 0.3094 | 1 | 1 | |
Brugia malayi | LBP / BPI / CETP family, C-terminal domain containing protein | 0.3094 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Concentration (functional) | = 100 uM | Concentration for low cytotoxic activity against L-132 cell line; Range is 50-100 microM | ChEMBL. | 14640548 |
Concentration (functional) | = 100 uM | Concentration for low cytotoxic activity against HeLa cell line; Range is 50-100 microM | ChEMBL. | 14640548 |
Concentration (functional) | = 100 uM | Concentration for low cytotoxic activity against MDA-MB-231 cell line; Range is 50-100 microM | ChEMBL. | 14640548 |
Concentration (functional) | = 100 uM | Concentration for low cytotoxic activity against MOLT-3 cell line; Range is 50-100 microM | ChEMBL. | 14640548 |
Concentration (functional) | = 100 uM | Concentration for low cytotoxic activity against L-132 cell line; Range is 50-100 microM | ChEMBL. | 14640548 |
Concentration (functional) | = 100 uM | Concentration for low cytotoxic activity against HeLa cell line; Range is 50-100 microM | ChEMBL. | 14640548 |
Concentration (functional) | = 100 uM | Concentration for low cytotoxic activity against MDA-MB-231 cell line; Range is 50-100 microM | ChEMBL. | 14640548 |
Concentration (functional) | = 100 uM | Concentration for low cytotoxic activity against MOLT-3 cell line; Range is 50-100 microM | ChEMBL. | 14640548 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.