Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.154951 | 1 | 1 |
Onchocerca volvulus | 0.154951 | 1 | 1 | |
Onchocerca volvulus | 0.349 | 1 | 1 | |
Loa Loa (eye worm) | LBP/BPI/CETP family domain-containing protein | 0.154951 | 1 | 1 |
Brugia malayi | LBP / BPI / CETP family, C-terminal domain containing protein | 0.349 | 1 | 1 |
Onchocerca volvulus | 0.349 | 1 | 1 | |
Onchocerca volvulus | 0.154951 | 1 | 1 | |
Brugia malayi | LBP / BPI / CETP family, N-terminal domain containing protein | 0.349 | 1 | 1 |
Onchocerca volvulus | 0.154951 | 1 | 1 | |
Onchocerca volvulus | 0.154951 | 1 | 1 | |
Brugia malayi | LBP / BPI / CETP family, N-terminal domain containing protein | 0.154951 | 1 | 1 |
Onchocerca volvulus | 0.349 | 1 | 1 | |
Onchocerca volvulus | 0.154951 | 1 | 1 | |
Onchocerca volvulus | 0.349 | 1 | 1 | |
Brugia malayi | LBP / BPI / CETP family, C-terminal domain containing protein | 0.154951 | 1 | 1 |
Onchocerca volvulus | 0.154951 | 1 | 1 | |
Onchocerca volvulus | 0.154951 | 1 | 1 | |
Loa Loa (eye worm) | hypothetical protein | 0.349 | 1 | 1 |
Brugia malayi | LBP / BPI / CETP family, N-terminal domain containing protein | 0.154951 | 1 | 1 |
Loa Loa (eye worm) | LBP/BPI/CETP family domain-containing protein | 0.349 | 1 | 1 |
Onchocerca volvulus | 0.349 | 1 | 1 | |
Onchocerca volvulus | 0.349 | 1 | 1 | |
Onchocerca volvulus | 0.349 | 1 | 1 | |
Onchocerca volvulus | 0.349 | 1 | 1 | |
Onchocerca volvulus | 0.154951 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (functional) | = 500 nM | Inhibition of scarpie prion formation in mouse ScN2a cell line | ChEMBL. | 16913719 |
Activity (functional) | = 500 nM | Inhibition of scarpie prion formation in mouse ScN2a cell line | ChEMBL. | 16913719 |
Activity (ADMET) | = 2500 nM | Toxicity against ScN2a cell line | ChEMBL. | 16913719 |
Activity (ADMET) | = 2500 nM | Toxicity against ScN2a cell line | ChEMBL. | 16913719 |
CC50 (ADMET) | = 1000 nM | Toxicity against MRC5 cell line | ChEMBL. | 16913719 |
CC50 (ADMET) | = 1000 nM | Toxicity against MRC5 cell line | ChEMBL. | 16913719 |
CC50 (functional) | = 1 uM | Cytotoxicity was tested on human diploid embryonic lung cell line (MRC-5) (in vitro) | ChEMBL. | 12570376 |
CC50 (functional) | = 1 uM | Cytotoxicity was tested on human diploid embryonic lung cell line (MRC-5) (in vitro) | ChEMBL. | 12570376 |
EC50 (functional) | = 100 nM | Inhibition of scarpie prion formation in mouse ScN2a cell line relative to control | ChEMBL. | 16913719 |
EC50 (functional) | = 100 nM | Inhibition of scarpie prion formation in mouse ScN2a cell line relative to control | ChEMBL. | 16913719 |
IC50 (functional) | = 16.7 nM | Antimalarial activity was determined by its inhibition of Plasmodium falciparum FcB1 strain (in vitro) | ChEMBL. | 12570376 |
IC50 (functional) | = 16.7 nM | Antimalaraial activity against CQ-resistant Plasmodium falciparum FcB1 | ChEMBL. | 16913719 |
IC50 (functional) | = 16.7 nM | Antimalarial activity was determined by its inhibition of Plasmodium falciparum FcB1 strain (in vitro) | ChEMBL. | 12570376 |
IC50 (functional) | = 16.7 nM | Antimalaraial activity against CQ-resistant Plasmodium falciparum FcB1 | ChEMBL. | 16913719 |
Selectivity index (functional) | = 10 | Selectivity index, toxicity against MRC5 cell line/EC50 for scarpie prion formation in mouse ScN2a cell line | ChEMBL. | 16913719 |
Selectivity index (functional) | = 25 | Selectivity index, toxicity against ScN2a cell line/EC50 for scarpie prion formation in mouse ScN2a cell line | ChEMBL. | 16913719 |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Mus musculus | ChEMBL23 | 16913719 | |
Plasmodium falciparum | ChEMBL23 | 12570376 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
2 literature references were collected for this gene.