Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Plasmodium falciparum | glutathione reductase | 0.0111 | 1 | 1 |
Echinococcus multilocularis | chromobox protein 1 | 0.0073 | 0.5152 | 0.197 |
Mycobacterium tuberculosis | NADPH-dependent mycothiol reductase Mtr | 0.0111 | 1 | 1 |
Giardia lamblia | NADH oxidase lateral transfer candidate | 0.0064 | 0.3963 | 0.5 |
Plasmodium vivax | glutathione reductase, putative | 0.0111 | 1 | 1 |
Loa Loa (eye worm) | thioredoxin reductase | 0.0111 | 1 | 1 |
Schistosoma mansoni | chromobox protein | 0.0073 | 0.5152 | 0.197 |
Brugia malayi | alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase | 0.0047 | 0.1839 | 0.0817 |
Trichomonas vaginalis | glutathione reductase, putative | 0.0064 | 0.3963 | 0.7056 |
Mycobacterium ulcerans | dihydrolipoamide dehydrogenase, LpdB | 0.0064 | 0.3963 | 0.5 |
Brugia malayi | dihydrolipoyl dehydrogenase, mitochondrial precursor, putative | 0.0064 | 0.3963 | 0.3207 |
Onchocerca volvulus | Heterochromatin protein 1 homolog | 0.0041 | 0.1113 | 0.7399 |
Plasmodium falciparum | thioredoxin reductase | 0.0111 | 1 | 1 |
Treponema pallidum | NADH oxidase | 0.0064 | 0.3963 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0041 | 0.1113 | 0.1113 |
Mycobacterium ulcerans | dihydrolipoamide dehydrogenase | 0.0064 | 0.3963 | 0.5 |
Toxoplasma gondii | thioredoxin reductase | 0.0111 | 1 | 1 |
Trypanosoma brucei | trypanothione reductase | 0.0111 | 1 | 1 |
Onchocerca volvulus | Heterochromatin protein 1 homolog | 0.0044 | 0.1504 | 1 |
Echinococcus multilocularis | chromobox protein 1 | 0.0073 | 0.5152 | 0.197 |
Mycobacterium leprae | DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE | 0.0064 | 0.3963 | 0.5 |
Trypanosoma cruzi | trypanothione reductase, putative | 0.0111 | 1 | 1 |
Loa Loa (eye worm) | glutathione reductase | 0.0111 | 1 | 1 |
Leishmania major | trypanothione reductase | 0.0111 | 1 | 1 |
Trichomonas vaginalis | chromobox protein, putative | 0.0073 | 0.5152 | 1 |
Chlamydia trachomatis | dihydrolipoyl dehydrogenase | 0.0064 | 0.3963 | 0.5 |
Trichomonas vaginalis | mercuric reductase, putative | 0.0064 | 0.3963 | 0.7056 |
Schistosoma mansoni | chromobox protein | 0.0073 | 0.5152 | 0.197 |
Echinococcus multilocularis | thioredoxin glutathione reductase | 0.0111 | 1 | 1 |
Wolbachia endosymbiont of Brugia malayi | dihydrolipoamide dehydrogenase E3 component | 0.0064 | 0.3963 | 0.5 |
Trichomonas vaginalis | chromobox protein, putative | 0.0044 | 0.1504 | 0.0969 |
Plasmodium vivax | thioredoxin reductase, putative | 0.0111 | 1 | 1 |
Mycobacterium ulcerans | flavoprotein disulfide reductase | 0.0064 | 0.3963 | 0.5 |
Trichomonas vaginalis | chromobox protein, putative | 0.0044 | 0.1504 | 0.0969 |
Brugia malayi | Thioredoxin reductase | 0.0111 | 1 | 1 |
Brugia malayi | Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein | 0.0047 | 0.1839 | 0.0817 |
Echinococcus granulosus | thioredoxin glutathione reductase | 0.0111 | 1 | 1 |
Trichomonas vaginalis | chromobox protein, putative | 0.0073 | 0.5152 | 1 |
Echinococcus granulosus | chromobox protein 1 | 0.0073 | 0.5152 | 0.197 |
Brugia malayi | Heterochromatin protein 1 | 0.0073 | 0.5152 | 0.4545 |
Loa Loa (eye worm) | heterochromatin protein 1 | 0.0073 | 0.5152 | 0.5152 |
Wolbachia endosymbiont of Brugia malayi | dihydrolipoamide dehydrogenase E3 component | 0.0064 | 0.3963 | 0.5 |
Echinococcus granulosus | chromobox protein 1 | 0.0073 | 0.5152 | 0.197 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | > 10 uM | Inhibitory concentration against T cell proliferation using concanavalin A stimulated mice spleen cells | ChEMBL. | 11229767 |
IC50 (functional) | > 30 uM | Inhibitory concentration against TNF-alpha production from human peripheral blood mononuclear cells stimulated by LPS | ChEMBL. | 11229767 |
IC50 (functional) | > 30 uM | Inhibitory concentration against growth of LPS stimulated human peripheral blood mononuclear cells | ChEMBL. | 11229767 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.