TDR Targets

Basic information

Technical information

TDR Targets ID: 26135
Name: [2,6-di(propan-2-yl)phenyl] N-(phenylsulfamoy l)carbamate
MW: 376.47 | Formula: C19H24N2O4S
H donors: 2 H acceptors: 3 LogP: 5.16 Rotable bonds: 8
Rule of 5 violations (Lipinski): 1
SMILES: O=C(NS(=O)(=O)Nc1ccccc1)Oc1c(cccc1C(C)C)C(C)C
InChi: 1S/C19H24N2O4S/c1-13(2)16-11-8-12-17(14(3)4)18(16)25-19(22)21-26(23,24)20-15-9-6-5-7-10-15/h5-14,20H,1-4H3,(H,21,22)
InChiKey: OPDGPYUVIVPEEU-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

(2,6-diisopropylphenyl) N-(phenylsulfamoyl)carbamate
N-(phenylsulfamoyl)carbamic acid (2,6-diisopropylphenyl) ester

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Onchocerca volvulus		0.0074	0.0688	0.5
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0074	0.0688	0.0238
Brugia malayi	G-protein-linked acetylcholine receptor protein 2, putative	0.0074	0.0688	0.12
Brugia malayi	sulfakinin receptor protein	0.0074	0.0688	0.12
Echinococcus multilocularis	thyrotropin releasing hormone receptor	0.0074	0.0688	0.0238
Brugia malayi	G-protein coupled receptor	0.0074	0.0688	0.12
Loa Loa (eye worm)	hypothetical protein	0.0074	0.0688	0.0688
Brugia malayi	hypothetical protein	0.0074	0.0688	0.12
Echinococcus multilocularis	neuropeptides capa receptor	0.0074	0.0688	0.0238
Loa Loa (eye worm)	hypothetical protein	0.0074	0.0688	0.0688
Echinococcus granulosus	neuropeptides capa receptor	0.0074	0.0688	0.0238
Loa Loa (eye worm)	G-protein coupled receptor	0.0074	0.0688	0.0688
Echinococcus multilocularis	dro:myosuppressin receptor	0.0074	0.0688	0.0238
Echinococcus granulosus	rhodopsin orphan GPCR	0.0074	0.0688	0.0238
Loa Loa (eye worm)	neuropeptide F receptor	0.0074	0.0688	0.0688
Loa Loa (eye worm)	hypothetical protein	0.0238	0.8738	0.8738
Echinococcus granulosus	neuropeptide Y receptor	0.0074	0.0688	0.0238
Loa Loa (eye worm)	G-protein coupled receptor	0.0074	0.0688	0.0688
Onchocerca volvulus		0.0074	0.0688	0.5
Echinococcus granulosus	7TM GPCR rhodopsin	0.0074	0.0688	0.0238
Echinococcus multilocularis	g protein coupled receptor	0.0074	0.0688	0.0238
Brugia malayi	ORL1-like opioid receptor	0.0074	0.0688	0.12
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0074	0.0688	0.0238
Brugia malayi	hypothetical protein	0.0074	0.0688	0.12
Brugia malayi	hypothetical protein	0.0074	0.0688	0.12
Echinococcus granulosus	fmrfamide receptor	0.0074	0.0688	0.0238
Echinococcus granulosus	neuropeptide Y receptor	0.0074	0.0688	0.0238
Loa Loa (eye worm)	5-hydroxytryptamine 2C receptor	0.0074	0.0688	0.0688
Echinococcus multilocularis	g protein coupled receptor	0.0074	0.0688	0.0238
Brugia malayi	Dihydroorotate dehydrogenase, mitochondrial precursor, putative	0.0177	0.5734	1
Brugia malayi	Dopamine receptor	0.0074	0.0688	0.12
Loa Loa (eye worm)	unidentified vitellogenin-linked transcript protein 6	0.0074	0.0688	0.0688
Brugia malayi	neuropeptide F receptor	0.0074	0.0688	0.12
Echinococcus granulosus	tm gpcr rhodopsin	0.0074	0.0688	0.0238
Loa Loa (eye worm)	hypothetical protein	0.0074	0.0688	0.0688
Onchocerca volvulus		0.0074	0.0688	0.5
Echinococcus granulosus	g protein coupled receptor	0.0074	0.0688	0.0238
Loa Loa (eye worm)	hypothetical protein	0.0074	0.0688	0.0688
Trichomonas vaginalis	dihydroorotate dehydrogenase, putative	0.0069	0.0461	0.5
Brugia malayi	GnHR receptor homolog	0.0074	0.0688	0.12
Loa Loa (eye worm)	hypothetical protein	0.0074	0.0688	0.0688
Loa Loa (eye worm)	TYRA-2 protein	0.0074	0.0688	0.0688
Echinococcus multilocularis	sex peptide receptor	0.0074	0.0688	0.0238
Loa Loa (eye worm)	gonadotropin-releasing hormone receptor 2	0.0074	0.0688	0.0688
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0074	0.0688	0.0238
Onchocerca volvulus		0.0074	0.0688	0.5
Echinococcus granulosus	rhodopsin orphan GPCR	0.0074	0.0688	0.0238
Loa Loa (eye worm)	hypothetical protein	0.0074	0.0688	0.0688
Echinococcus granulosus	biogenic amine 5HT receptor	0.0074	0.0688	0.0238
Echinococcus granulosus	rhodopsin orphan GPCR	0.0074	0.0688	0.0238
Loa Loa (eye worm)	hypothetical protein	0.0074	0.0688	0.0688
Onchocerca volvulus		0.0074	0.0688	0.5
Loa Loa (eye worm)	follicle stimulating hormone receptor	0.0074	0.0688	0.0688
Brugia malayi	Zinc finger, C2H2 type family protein	0.0069	0.0461	0.0805
Echinococcus multilocularis	G protein coupled 5 hydroxytryptamine receptor	0.0074	0.0688	0.0238
Brugia malayi	Serotonin/octopamine receptor family protein 7	0.0074	0.0688	0.12
Brugia malayi	Tachykinin-like peptides receptor 99D	0.0074	0.0688	0.12
Echinococcus multilocularis	neuropeptides capa receptor	0.0074	0.0688	0.0238
Loa Loa (eye worm)	hypothetical protein	0.0074	0.0688	0.0688
Loa Loa (eye worm)	hypothetical protein	0.0074	0.0688	0.0688
Echinococcus multilocularis	neuropeptide Y receptor	0.0074	0.0688	0.0238
Echinococcus multilocularis	alpha 1A adrenergic receptor	0.0074	0.0688	0.0238
Echinococcus granulosus	7tm_1 domain containing protein	0.0074	0.0688	0.0238
Brugia malayi	neuropeptide F receptor	0.0074	0.0688	0.12
Onchocerca volvulus		0.0074	0.0688	0.5
Echinococcus multilocularis	allatostatin A receptor	0.0074	0.0688	0.0238
Echinococcus multilocularis	g protein coupled receptor	0.0074	0.0688	0.0238
Loa Loa (eye worm)	hypothetical protein	0.0074	0.0688	0.0688
Brugia malayi	hypothetical protein	0.0074	0.0688	0.12
Echinococcus multilocularis	somatostatin receptor	0.0074	0.0688	0.0238
Brugia malayi	hypothetical protein	0.0074	0.0688	0.12
Echinococcus multilocularis	G-protein coupled receptor, putative	0.0074	0.0688	0.0238
Echinococcus granulosus	alpha 1A adrenergic receptor	0.0074	0.0688	0.0238
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0074	0.0688	0.0238
Echinococcus granulosus	orexin receptor type 2	0.0074	0.0688	0.0238
Loa Loa (eye worm)	hypothetical protein	0.0264	1	1
Trypanosoma cruzi	dihydroorotate dehydrogenase, putative	0.0177	0.5734	1
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0074	0.0688	0.0238
Loa Loa (eye worm)	hypothetical protein	0.0074	0.0688	0.0688
Loa Loa (eye worm)	hypothetical protein	0.0074	0.0688	0.0688
Echinococcus multilocularis	fmrfamide receptor	0.0074	0.0688	0.0238
Echinococcus multilocularis	serotonin receptor	0.0074	0.0688	0.0238
Echinococcus multilocularis	serotonin receptor	0.0074	0.0688	0.0238
Loa Loa (eye worm)	hypothetical protein	0.0074	0.0688	0.0688
Echinococcus granulosus	rhodopsin orphan GPCR	0.0074	0.0688	0.0238
Echinococcus multilocularis	7TM GPCR, rhodopsin	0.0074	0.0688	0.0238
Loa Loa (eye worm)	hypothetical protein	0.0074	0.0688	0.0688
Echinococcus granulosus	biogenic amine 5HT receptor	0.0074	0.0688	0.0238
Brugia malayi	G protein-coupled receptor F59B2.13	0.0074	0.0688	0.12
Toxoplasma gondii	dihydroorotate dehydrogenase reveal, putative	0.0177	0.5734	0.5
Brugia malayi	Dopamine receptor protein 2	0.0074	0.0688	0.12
Trichomonas vaginalis	dihydroorotate dehydrogenase, putative	0.0069	0.0461	0.5
Brugia malayi	putative neuropeptide receptor NPR1	0.0074	0.0688	0.12
Schistosoma mansoni	dihydroorotate dehydrogenase	0.0177	0.5734	0.5418
Echinococcus granulosus	g protein coupled receptor	0.0074	0.0688	0.0238
Trichomonas vaginalis	dihydroorotate dehydrogenase, putative	0.0069	0.0461	0.5
Loa Loa (eye worm)	hypothetical protein	0.0074	0.0688	0.0688
Echinococcus granulosus	dro:myosuppressin receptor	0.0074	0.0688	0.0238
Onchocerca volvulus		0.0074	0.0688	0.5
Brugia malayi	Serotonin receptor	0.0074	0.0688	0.12
Loa Loa (eye worm)	hypothetical protein	0.0074	0.0688	0.0688
Loa Loa (eye worm)	hypothetical protein	0.0074	0.0688	0.0688
Echinococcus granulosus	g-protein coupled receptor	0.0074	0.0688	0.0238
Onchocerca volvulus	Neuropeptide F receptor homolog	0.0074	0.0688	0.5
Loa Loa (eye worm)	hypothetical protein	0.0074	0.0688	0.0688
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0074	0.0688	0.0238
Onchocerca volvulus		0.0074	0.0688	0.5
Loa Loa (eye worm)	hypothetical protein	0.0074	0.0688	0.0688
Brugia malayi	Unidentified vitellogenin-linked transcript protein 6, putative	0.0074	0.0688	0.12
Echinococcus granulosus	G protein coupled 5 hydroxytryptamine receptor	0.0074	0.0688	0.0238
Loa Loa (eye worm)	melatonin receptor type 1A	0.0074	0.0688	0.0688
Echinococcus granulosus	neuropeptide FF receptor 2	0.0074	0.0688	0.0238
Trichomonas vaginalis	dihydroorotate dehydrogenase, putative	0.0069	0.0461	0.5
Onchocerca volvulus		0.0074	0.0688	0.5
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0074	0.0688	0.0238
Onchocerca volvulus		0.0074	0.0688	0.5
Loa Loa (eye worm)	hypothetical protein	0.0074	0.0688	0.0688
Brugia malayi	hypothetical protein	0.0074	0.0688	0.12
Loa Loa (eye worm)	hypothetical protein	0.0074	0.0688	0.0688
Brugia malayi	G protein-coupled receptor	0.0074	0.0688	0.12
Echinococcus granulosus	neuropeptide receptor A26	0.0074	0.0688	0.0238
Onchocerca volvulus		0.0074	0.0688	0.5
Loa Loa (eye worm)	hypothetical protein	0.0074	0.0688	0.0688
Loa Loa (eye worm)	hypothetical protein	0.0074	0.0688	0.0688
Brugia malayi	G-protein coupled receptor	0.0074	0.0688	0.12
Echinococcus granulosus	rhodopsin orphan GPCR	0.0074	0.0688	0.0238
Loa Loa (eye worm)	hypothetical protein	0.0074	0.0688	0.0688
Onchocerca volvulus		0.0074	0.0688	0.5
Plasmodium vivax	dihydroorotate dehydrogenase, mitochondrial precursor, putative	0.0177	0.5734	0.5
Mycobacterium leprae	Probable dihydroorotate dehydrogenase PyrD	0.0177	0.5734	0.5
Loa Loa (eye worm)	hypothetical protein	0.0074	0.0688	0.0688
Loa Loa (eye worm)	hypothetical protein	0.0074	0.0688	0.0688
Brugia malayi	hypothetical protein	0.0074	0.0688	0.12
Echinococcus granulosus	serotonin receptor	0.0074	0.0688	0.0238
Onchocerca volvulus		0.0074	0.0688	0.5
Echinococcus multilocularis	neuropeptide receptor A26	0.0074	0.0688	0.0238
Echinococcus granulosus	growth hormone secretagogue receptor type 1	0.0074	0.0688	0.0238
Loa Loa (eye worm)	hypothetical protein	0.0074	0.0688	0.0688
Schistosoma mansoni	sterol O-acyltransferase 1	0.0264	1	1
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0074	0.0688	0.0238
Echinococcus granulosus	allatostatin A receptor	0.0074	0.0688	0.0238
Mycobacterium ulcerans	dihydroorotate dehydrogenase 2	0.0177	0.5734	0.5
Echinococcus multilocularis	neuropeptide receptor	0.0074	0.0688	0.0238
Loa Loa (eye worm)	neuropeptide F receptor	0.0074	0.0688	0.0688
Loa Loa (eye worm)	hypothetical protein	0.0074	0.0688	0.0688
Trichomonas vaginalis	dihydroorotate dehydrogenase, putative	0.0069	0.0461	0.5
Echinococcus multilocularis	orexin receptor type 2	0.0074	0.0688	0.0238
Wolbachia endosymbiont of Brugia malayi	dihydroorotate dehydrogenase 2	0.0177	0.5734	0.5
Loa Loa (eye worm)	hypothetical protein	0.0074	0.0688	0.0688
Loa Loa (eye worm)	hypothetical protein	0.0074	0.0688	0.0688
Echinococcus multilocularis	neuropeptide s receptor	0.0074	0.0688	0.0238
Echinococcus granulosus	G protein coupled receptor 139	0.0074	0.0688	0.0238
Echinococcus granulosus	sex peptide receptor	0.0074	0.0688	0.0238
Trichomonas vaginalis	dihydropyrimidine dehydrogenase, putative	0.0069	0.0461	0.5
Brugia malayi	larval opioid receptor	0.0074	0.0688	0.12
Echinococcus granulosus	thyrotropin releasing hormone receptor	0.0074	0.0688	0.0238
Loa Loa (eye worm)	hypothetical protein	0.0074	0.0688	0.0688
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0074	0.0688	0.0238
Echinococcus multilocularis	biogenic amine (5HT) receptor	0.0074	0.0688	0.0238
Loa Loa (eye worm)	hypothetical protein	0.0074	0.0688	0.0688
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0074	0.0688	0.0238
Echinococcus granulosus	tm gpcr rhodopsin	0.0074	0.0688	0.0238
Loa Loa (eye worm)	hypothetical protein	0.0074	0.0688	0.0688
Brugia malayi	Dihydroorotate dehydrogenase, mitochondrial precursor, putative	0.0177	0.5734	1
Brugia malayi	putative neuropeptide receptor	0.0074	0.0688	0.12
Trypanosoma brucei	dihydroorotate dehydrogenase (fumarate)	0.0177	0.5734	0.5
Brugia malayi	Dopamine receptor protein 1, putative (partial)	0.0074	0.0688	0.12
Loa Loa (eye worm)	hypothetical protein	0.0074	0.0688	0.0688
Echinococcus granulosus	somatostatin receptor	0.0074	0.0688	0.0238
Loa Loa (eye worm)	hypothetical protein	0.0074	0.0688	0.0688
Loa Loa (eye worm)	hypothetical protein	0.0074	0.0688	0.0688
Echinococcus multilocularis	growth hormone secretagogue receptor type 1	0.0074	0.0688	0.0238
Brugia malayi	Serotonin receptor	0.0074	0.0688	0.12
Loa Loa (eye worm)	hypothetical protein	0.0074	0.0688	0.0688
Plasmodium falciparum	dihydroorotate dehydrogenase	0.0177	0.5734	0.5
Loa Loa (eye worm)	hypothetical protein	0.0074	0.0688	0.0688
Loa Loa (eye worm)	hypothetical protein	0.0074	0.0688	0.0688
Brugia malayi	hypothetical protein	0.0074	0.0688	0.12
Echinococcus granulosus	hypothetical protein	0.0074	0.0688	0.0238
Echinococcus granulosus	neuropeptide receptor	0.0074	0.0688	0.0238
Loa Loa (eye worm)	hypothetical protein	0.0074	0.0688	0.0688
Mycobacterium tuberculosis	Probable dihydroorotate dehydrogenase PyrD	0.0177	0.5734	0.5
Echinococcus multilocularis	tachykinin peptides receptor 99D	0.0074	0.0688	0.0238
Echinococcus multilocularis	peptide (allatostatin:somatostatin)	0.0074	0.0688	0.0238
Brugia malayi	hypothetical protein	0.0074	0.0688	0.12
Echinococcus granulosus	tachykinin peptides receptor 99D	0.0074	0.0688	0.0238
Echinococcus granulosus	neuropeptide receptor	0.0074	0.0688	0.0238
Trypanosoma cruzi	dihydroorotate dehydrogenase, putative	0.0177	0.5734	1
Onchocerca volvulus	Dopamine\/Ecdysteroid receptor homolog	0.0074	0.0688	0.5
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0074	0.0688	0.0238
Echinococcus granulosus	rhodopsin orphan GPCR	0.0074	0.0688	0.0238
Brugia malayi	Melatonin receptor type 1A	0.0074	0.0688	0.12
Echinococcus multilocularis	G protein coupled receptor 139	0.0074	0.0688	0.0238
Echinococcus multilocularis	pyroglutamylated rfamide peptide receptor	0.0074	0.0688	0.0238
Trypanosoma cruzi	dihydroorotate dehydrogenase (fumarate), putative	0.0177	0.5734	1
Echinococcus multilocularis	sterol O acyltransferase 1	0.0264	1	1
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0074	0.0688	0.0238
Loa Loa (eye worm)	G-protein-linked acetylcholine receptor protein 2	0.0074	0.0688	0.0688
Brugia malayi	RE15519p	0.0074	0.0688	0.12
Loa Loa (eye worm)	hypothetical protein	0.0074	0.0688	0.0688
Brugia malayi	AKH receptor	0.0074	0.0688	0.12
Leishmania major	dihydroorotate dehydrogenase	0.0177	0.5734	0.5
Echinococcus granulosus	g protein coupled receptor	0.0074	0.0688	0.0238
Echinococcus multilocularis	neuropeptide receptor	0.0074	0.0688	0.0238
Brugia malayi	follicle stimulating hormone receptor	0.0074	0.0688	0.12
Brugia malayi	gonadotropin-releasing hormone receptor 2	0.0074	0.0688	0.12
Onchocerca volvulus		0.0074	0.0688	0.5
Loa Loa (eye worm)	hypothetical protein	0.0074	0.0688	0.0688
Echinococcus granulosus	pyroglutamylated rfamide peptide receptor	0.0074	0.0688	0.0238
Brugia malayi	hypothetical protein	0.0074	0.0688	0.12
Loa Loa (eye worm)	hypothetical protein	0.0074	0.0688	0.0688
Onchocerca volvulus		0.0074	0.0688	0.5
Entamoeba histolytica	dihydropyrimidine dehydrogenase, putative	0.0069	0.0461	0.5
Loa Loa (eye worm)	hypothetical protein	0.0074	0.0688	0.0688
Loa Loa (eye worm)	hypothetical protein	0.0074	0.0688	0.0688
Echinococcus multilocularis	neuropeptide Y receptor	0.0074	0.0688	0.0238
Echinococcus multilocularis	neuropeptide FF receptor 2	0.0074	0.0688	0.0238
Brugia malayi	Dopamine receptor protein 1	0.0074	0.0688	0.12
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0074	0.0688	0.0238
Echinococcus multilocularis	g-protein coupled receptor	0.0074	0.0688	0.0238
Echinococcus multilocularis	fmrfamide receptor	0.0074	0.0688	0.0238
Onchocerca volvulus		0.0074	0.0688	0.5
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0074	0.0688	0.0238
Echinococcus granulosus	tm gpcr rhodopsin	0.0074	0.0688	0.0238
Echinococcus granulosus	neuropeptides capa receptor	0.0074	0.0688	0.0238
Echinococcus granulosus	neuropeptide s receptor	0.0074	0.0688	0.0238
Echinococcus granulosus	peptide allatostatin:somatostatin	0.0074	0.0688	0.0238
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0074	0.0688	0.0238
Echinococcus granulosus	rhodopsin orphan GPCR	0.0074	0.0688	0.0238
Onchocerca volvulus		0.0074	0.0688	0.5

Activities

Activity type	Activity value	Assay description	Source	Reference
Delta HDL (functional)	= 240 %	Chronic in vivo activity of the compound was measured by the concentration of high density lipoproteins (HDL) in cholesterol fed rats	ChEMBL.	8632431
Delta HDL (functional)	= 240 %	Chronic in vivo activity of the compound was measured by the concentration of high density lipoproteins (HDL) in cholesterol fed rats	ChEMBL.	8632431
Delta TC (functional)	= -55 %	Acute in vivo activity of the compound was measured by the total plasma cholesterol concentration levels(TC) at dose 50 mg/kg	ChEMBL.	8632431
Delta TC (functional)	= -55 %	Acute in vivo activity of the compound was measured by the total plasma cholesterol concentration levels(TC) at dose 50 mg/kg	ChEMBL.	8632431
Delta TC (functional)	= -33 %	Chronic in vivo activity of the compound was measured by the total cholesterol concentration levels in cholesterol fed rats	ChEMBL.	8632431
Delta TC (functional)	= -33 %	Chronic in vivo activity of the compound was measured by the total cholesterol concentration levels in cholesterol fed rats	ChEMBL.	8632431
IC50 (binding)	= 38.1 uM	In vitro inhibitory activity against acyl coenzyme A:cholesterol acyltransferase 1 in microsomes of rat liver	ChEMBL.	8632431
IC50 (binding)	= 38.1 uM	In vitro inhibitory activity against acyl coenzyme A:cholesterol acyltransferase 1 in microsomes of rat liver	ChEMBL.	8632431

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL277914
PubChem: 10833368

Bibliographic References

1 literature reference was collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.

Detailed information for compound 26135