Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | carbonic anhydrase II (carbonate dehydratase II) | 0.0522 | 1 | 1 |
Schistosoma mansoni | carbonic anhydrase | 0.023 | 0.3149 | 0.0282 |
Mycobacterium ulcerans | carbonic anhydrase | 0.0222 | 0.2951 | 1 |
Mycobacterium tuberculosis | Beta-carbonic anhydrase CanB | 0.0126 | 0.0703 | 1 |
Schistosoma mansoni | carbonic anhydrase II (carbonate dehydratase II) | 0.0522 | 1 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0096 | 0 | 0.5 |
Brugia malayi | Putative carbonic anhydrase 5 precursor | 0.0522 | 1 | 1 |
Schistosoma mansoni | hypothetical protein | 0.023 | 0.3149 | 0.0282 |
Loa Loa (eye worm) | eukaryotic-type carbonic anhydrase | 0.0522 | 1 | 1 |
Entamoeba histolytica | carbonic anhydrase, putative | 0.0222 | 0.2951 | 0.5 |
Trypanosoma brucei | carbonic anhydrase-like protein | 0.0522 | 1 | 0.5 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0096 | 0 | 0.5 |
Plasmodium falciparum | carbonic anhydrase | 0.023 | 0.3149 | 0.5 |
Leishmania major | carbonic anhydrase-like protein | 0.0522 | 1 | 1 |
Schistosoma mansoni | carbonic anhydrase-related | 0.023 | 0.3149 | 0.0282 |
Schistosoma mansoni | carbonic anhydrase-related | 0.023 | 0.3149 | 0.0282 |
Trypanosoma cruzi | carbonic anhydrase-like protein, putative | 0.0522 | 1 | 0.5 |
Toxoplasma gondii | hypothetical protein | 0.023 | 0.3149 | 0.5 |
Schistosoma mansoni | carbonic anhydrase-related | 0.023 | 0.3149 | 0.0282 |
Loa Loa (eye worm) | carbonic anhydrase 3 | 0.0522 | 1 | 1 |
Echinococcus multilocularis | carbonic anhydrase II | 0.0522 | 1 | 1 |
Trypanosoma cruzi | carbonic anhydrase-like protein, putative | 0.0522 | 1 | 0.5 |
Echinococcus granulosus | carbonic anhydrase II | 0.0522 | 1 | 1 |
Mycobacterium leprae | CARBONIC ANHYDRASE (CARBONATE DEHYDRATASE) (CARBONIC DEHYDRATASE) | 0.0222 | 0.2951 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 25 uM | Inhibition of phosphorylation of a random glutamate/tyrosine copolymer in lysates of transfected Sf9 insect cells overexpressing mouse platelet-derived growth factor receptor beta | ChEMBL. | 9876115 |
IC50 (binding) | = 25 uM | Inhibition of phosphorylation of a random glutamate/tyrosine copolymer in lysates of transfected Sf9 insect cells overexpressing mouse platelet-derived growth factor receptor beta | ChEMBL. | 9876115 |
IC50 (binding) | > 50 uM | Inhibition of phosphorylation of a random glutamate/tyrosine copolymer in lysates of transfected Sf9 insect cells overexpressing human fibroblast growth factor receptor 1 | ChEMBL. | 9876115 |
IC50 (binding) | > 50 uM | Inhibition of phosphorylation of a random glutamate/tyrosine copolymer in lysates of transfected Sf9 insect cells overexpressing human fibroblast growth factor receptor 1 | ChEMBL. | 9876115 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.