Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | latrophilin 2 splice variant baaae | 0.0034 | 0.0529 | 0.0529 |
Schistosoma mansoni | hypothetical protein | 0.0016 | 0.0073 | 0.0073 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.005 | 0.0922 | 0.0922 |
Onchocerca volvulus | Dopamine\/Ecdysteroid receptor homolog | 0.0013 | 0 | 0.5 |
Echinococcus granulosus | diuretic hormone 44 receptor GPRdih2 | 0.0016 | 0.0073 | 0.0073 |
Loa Loa (eye worm) | hypothetical protein | 0.0016 | 0.0073 | 0.0073 |
Onchocerca volvulus | Neuropeptide F receptor homolog | 0.0013 | 0 | 0.5 |
Onchocerca volvulus | 0.0013 | 0 | 0.5 | |
Onchocerca volvulus | 0.0013 | 0 | 0.5 | |
Echinococcus multilocularis | GPCR, family 2 | 0.0016 | 0.0073 | 0.0073 |
Echinococcus granulosus | raf serine:threonine protein kinase | 0.0164 | 0.3751 | 0.3751 |
Onchocerca volvulus | 0.0013 | 0 | 0.5 | |
Loa Loa (eye worm) | hypothetical protein | 0.005 | 0.0922 | 0.0922 |
Schistosoma mansoni | gamma-secretase subunit aph-1 | 0.0417 | 1 | 1 |
Brugia malayi | Raf kinase | 0.0159 | 0.3609 | 0.3609 |
Loa Loa (eye worm) | gamma-secretase subunit aph-1 | 0.0417 | 1 | 1 |
Trypanosoma cruzi | Aph-1 protein, putative | 0.0162 | 0.3702 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0034 | 0.0529 | 0.0529 |
Schistosoma mansoni | hypothetical protein | 0.0016 | 0.0073 | 0.0073 |
Echinococcus granulosus | GPCR family 2 | 0.0016 | 0.0073 | 0.0073 |
Echinococcus granulosus | gamma secretase subunit aph 1 | 0.0417 | 1 | 1 |
Echinococcus multilocularis | cadherin EGF LAG seven pass G type receptor | 0.0016 | 0.0073 | 0.0073 |
Echinococcus granulosus | cadherin EGF LAG seven pass G type receptor | 0.0016 | 0.0073 | 0.0073 |
Onchocerca volvulus | 0.0013 | 0 | 0.5 | |
Onchocerca volvulus | 0.0013 | 0 | 0.5 | |
Schistosoma mansoni | serine/threonine protein kinase | 0.0164 | 0.3751 | 0.3751 |
Onchocerca volvulus | 0.0013 | 0 | 0.5 | |
Trypanosoma brucei | Aph-1 protein, putative | 0.0162 | 0.3702 | 0.5 |
Onchocerca volvulus | 0.0013 | 0 | 0.5 | |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.005 | 0.0922 | 0.0922 |
Onchocerca volvulus | 0.0013 | 0 | 0.5 | |
Onchocerca volvulus | 0.0013 | 0 | 0.5 | |
Onchocerca volvulus | 0.0013 | 0 | 0.5 | |
Onchocerca volvulus | 0.0013 | 0 | 0.5 | |
Onchocerca volvulus | 0.0013 | 0 | 0.5 | |
Loa Loa (eye worm) | TKL/RAF/RAF protein kinase | 0.0093 | 0.1989 | 0.1989 |
Schistosoma mansoni | hypothetical protein | 0.0016 | 0.0073 | 0.0073 |
Onchocerca volvulus | 0.0013 | 0 | 0.5 | |
Echinococcus multilocularis | raf serine:threonine protein kinase | 0.0164 | 0.3751 | 0.3751 |
Loa Loa (eye worm) | latrophilin receptor protein 2 | 0.0016 | 0.0073 | 0.0073 |
Onchocerca volvulus | 0.0013 | 0 | 0.5 | |
Onchocerca volvulus | 0.0013 | 0 | 0.5 | |
Brugia malayi | Latrophilin receptor protein 2 | 0.0016 | 0.0073 | 0.0073 |
Loa Loa (eye worm) | raf kinase | 0.0164 | 0.3732 | 0.3732 |
Echinococcus multilocularis | gamma secretase subunit aph 1 | 0.0417 | 1 | 1 |
Echinococcus multilocularis | diuretic hormone 44 receptor GPRdih2 | 0.0016 | 0.0073 | 0.0073 |
Onchocerca volvulus | 0.0013 | 0 | 0.5 | |
Schistosoma mansoni | hypothetical protein | 0.0016 | 0.0073 | 0.0073 |
Loa Loa (eye worm) | hypothetical protein | 0.0034 | 0.0529 | 0.0529 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.005 | 0.0922 | 0.0922 |
Onchocerca volvulus | 0.0013 | 0 | 0.5 | |
Trypanosoma cruzi | Aph-1 protein, putative | 0.0162 | 0.3702 | 0.5 |
Brugia malayi | calcium-independent alpha-latrotoxin receptor 2, putative | 0.0016 | 0.0073 | 0.0073 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Competition factor (binding) | Binding affinity for rat androgen receptor compared to dihydrotestosterone; No affinity | ChEMBL. | 3989815 | |
Competition factor (binding) | = 195 | Binding affinity for rat progesterone receptor compared to progesterone | ChEMBL. | 3989815 |
Competition factor (binding) | 0 | Binding affinity for rat androgen receptor compared to dihydrotestosterone; No affinity | ChEMBL. | 3989815 |
Competition factor (binding) | = 195 | Binding affinity for rat progesterone receptor compared to progesterone | ChEMBL. | 3989815 |
MRP (functional) | Relative potency as antialdosterone activity compared to spironolactone 1 hr after oral administration; No activity | ChEMBL. | 3989815 | |
MRP (functional) | 0 | Relative potency as antialdosterone activity compared to spironolactone 1 hr after oral administration; No activity | ChEMBL. | 3989815 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.