Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trichomonas vaginalis | Sialidase-1 precursor, putative | 0.1726 | 0.5 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
k obs / 1 (binding) | = 64 M-1 s-1 | The second order inactivation rate constant was expressed as inhibition of chymotrypsin (ChT).Inhibitor concentrations were 360-570 microM. | ChEMBL. | 7853347 |
k obs / 1 (binding) | = 64 M-1 s-1 | The second order inactivation rate constant was expressed as inhibition of chymotrypsin (ChT).Inhibitor concentrations were 360-570 microM. | ChEMBL. | 7853347 |
k obs / 1 (binding) | = 1600 M-1 s-1 | The second order inactivation rate constant was expressed as inhibition of porcine pancreatic elastase (PPE).Inhibitor concentrations were 2-600 microM. | ChEMBL. | 7853347 |
k obs / 1 (binding) | = 1600 M-1 s-1 | The second order inactivation rate constant was expressed as inhibition of porcine pancreatic elastase (PPE).Inhibitor concentrations were 2-600 microM. | ChEMBL. | 7853347 |
k obs / 1 (binding) | = 130000 M-1 s-1 | The second order inactivation rate constant was expressed as inhibition of human leukocyte elastase(HLE).Inhibitor concentrations were 0.4-4 microM. | ChEMBL. | 7853347 |
k obs / 1 (binding) | = 130000 M-1 s-1 | The second order inactivation rate constant was expressed as inhibition of human leukocyte elastase(HLE).Inhibitor concentrations were 0.4-4 microM. | ChEMBL. | 7853347 |
T1/2 (ADMET) | > 48 hr | Half-life for hydrolysis of compound was determined from kinetic constant. | ChEMBL. | 7853347 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.