Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | peptide (FMRFamide/neurokinin-3)-like receptor | 0.0078 | 0.0276 | 0.0276 |
Brugia malayi | hypothetical protein | 0.0078 | 0.0276 | 0.0276 |
Brugia malayi | Unidentified vitellogenin-linked transcript protein 6, putative | 0.0078 | 0.0276 | 0.0276 |
Brugia malayi | neuropeptide F receptor | 0.0078 | 0.0276 | 0.0276 |
Loa Loa (eye worm) | hypothetical protein | 0.0078 | 0.0276 | 0.027 |
Schistosoma mansoni | amine GPCR | 0.0078 | 0.0276 | 0.0276 |
Brugia malayi | hypothetical protein | 0.0078 | 0.0276 | 0.0276 |
Brugia malayi | hypothetical protein | 0.0078 | 0.0276 | 0.0276 |
Loa Loa (eye worm) | unidentified vitellogenin-linked transcript protein 6 | 0.0078 | 0.0276 | 0.027 |
Schistosoma mansoni | adenoreceptor | 0.0078 | 0.0276 | 0.0276 |
Loa Loa (eye worm) | hypothetical protein | 0.0078 | 0.0276 | 0.027 |
Brugia malayi | hypothetical protein | 0.0078 | 0.0276 | 0.0276 |
Loa Loa (eye worm) | melatonin receptor type 1A | 0.0078 | 0.0276 | 0.027 |
Brugia malayi | G-protein-linked acetylcholine receptor protein 2, putative | 0.0078 | 0.0276 | 0.0276 |
Schistosoma mansoni | histamine h1 receptor | 0.0078 | 0.0276 | 0.0276 |
Trypanosoma brucei | cAMP phosphodiesterase A, putative | 0.0343 | 0.3053 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0078 | 0.0276 | 0.0276 |
Brugia malayi | follicle stimulating hormone receptor | 0.0078 | 0.0276 | 0.0276 |
Loa Loa (eye worm) | 5-hydroxytryptamine 2C receptor | 0.0078 | 0.0276 | 0.027 |
Onchocerca volvulus | 0.0078 | 0.0276 | 1 | |
Schistosoma mansoni | rhodopsin-like orphan GPCR | 0.0078 | 0.0276 | 0.0276 |
Loa Loa (eye worm) | hypothetical protein | 0.0078 | 0.0276 | 0.027 |
Schistosoma mansoni | amine GPCR | 0.0078 | 0.0276 | 0.0276 |
Schistosoma mansoni | peptide (FMRFamide/somatostatin)-like receptor | 0.0078 | 0.0276 | 0.0276 |
Brugia malayi | hypothetical protein | 0.0078 | 0.0276 | 0.0276 |
Loa Loa (eye worm) | hypothetical protein | 0.0078 | 0.0276 | 0.027 |
Onchocerca volvulus | 0.0078 | 0.0276 | 1 | |
Schistosoma mansoni | biogenic amine (5HT) receptor | 0.0078 | 0.0276 | 0.0276 |
Brugia malayi | hypothetical protein | 0.0078 | 0.0276 | 0.0276 |
Schistosoma mansoni | neuropeptide receptor | 0.0078 | 0.0276 | 0.0276 |
Loa Loa (eye worm) | hypothetical protein | 0.0078 | 0.0276 | 0.027 |
Onchocerca volvulus | 0.0078 | 0.0276 | 1 | |
Brugia malayi | neuropeptide F receptor | 0.0078 | 0.0276 | 0.0276 |
Brugia malayi | Melatonin receptor type 1A | 0.0078 | 0.0276 | 0.0276 |
Loa Loa (eye worm) | hypothetical protein | 0.0078 | 0.0276 | 0.027 |
Loa Loa (eye worm) | hypothetical protein | 0.0078 | 0.0276 | 0.027 |
Loa Loa (eye worm) | hypothetical protein | 0.0078 | 0.0276 | 0.027 |
Onchocerca volvulus | 0.0078 | 0.0276 | 1 | |
Onchocerca volvulus | 0.0078 | 0.0276 | 1 | |
Toxoplasma gondii | 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein | 0.0343 | 0.3053 | 0.5 |
Brugia malayi | hypothetical protein | 0.0078 | 0.0276 | 0.0276 |
Schistosoma mansoni | amine GPCR | 0.0078 | 0.0276 | 0.0276 |
Loa Loa (eye worm) | hypothetical protein | 0.0078 | 0.0276 | 0.027 |
Schistosoma mansoni | rhodopsin-like orphan GPCR | 0.0078 | 0.0276 | 0.0276 |
Onchocerca volvulus | 0.0078 | 0.0276 | 1 | |
Brugia malayi | Serotonin/octopamine receptor family protein 7 | 0.0078 | 0.0276 | 0.0276 |
Loa Loa (eye worm) | hypothetical protein | 0.0078 | 0.0276 | 0.027 |
Schistosoma mansoni | rhodopsin-like orphan GPCR | 0.0078 | 0.0276 | 0.0276 |
Schistosoma mansoni | hypothetical protein | 0.0078 | 0.0276 | 0.0276 |
Brugia malayi | Serotonin receptor | 0.0078 | 0.0276 | 0.0276 |
Schistosoma mansoni | biogenic amine (dopamine) receptor | 0.0078 | 0.0276 | 0.0276 |
Schistosoma mansoni | calcium/calmodulin-dependent 35-cyclic nucleotide phosphodiesterase | 0.1006 | 1 | 1 |
Trypanosoma cruzi | cAMP phosphodiesterase A, putative | 0.0343 | 0.3053 | 0.5 |
Onchocerca volvulus | 0.0078 | 0.0276 | 1 | |
Loa Loa (eye worm) | hypothetical protein | 0.0078 | 0.0276 | 0.027 |
Loa Loa (eye worm) | hypothetical protein | 0.0078 | 0.0276 | 0.027 |
Loa Loa (eye worm) | hypothetical protein | 0.0078 | 0.0276 | 0.027 |
Brugia malayi | Dopamine receptor | 0.0078 | 0.0276 | 0.0276 |
Loa Loa (eye worm) | hypothetical protein | 0.0078 | 0.0276 | 0.027 |
Brugia malayi | hypothetical protein | 0.0078 | 0.0276 | 0.0276 |
Loa Loa (eye worm) | hypothetical protein | 0.0078 | 0.0276 | 0.027 |
Schistosoma mansoni | biogenic amine (dopamine) receptor | 0.0078 | 0.0276 | 0.0276 |
Brugia malayi | hypothetical protein | 0.0078 | 0.0276 | 0.0276 |
Loa Loa (eye worm) | TYRA-2 protein | 0.0078 | 0.0276 | 0.027 |
Schistosoma mansoni | neuropeptide F-like receptor | 0.0078 | 0.0276 | 0.0276 |
Onchocerca volvulus | 0.0078 | 0.0276 | 1 | |
Plasmodium vivax | 3',5'-cyclic nucleotide phosphodiesterase, putative | 0.0343 | 0.3053 | 0.5 |
Loa Loa (eye worm) | follicle stimulating hormone receptor | 0.0078 | 0.0276 | 0.027 |
Loa Loa (eye worm) | hypothetical protein | 0.0078 | 0.0276 | 0.027 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0053 | 0.0007 | 0.0007 |
Schistosoma mansoni | hypothetical protein | 0.0078 | 0.0276 | 0.0276 |
Schistosoma mansoni | biogenic amine (dopamine) receptor | 0.0078 | 0.0276 | 0.0276 |
Schistosoma mansoni | peptide (allatostatin)-like receptor | 0.0078 | 0.0276 | 0.0276 |
Brugia malayi | Dopamine receptor protein 2 | 0.0078 | 0.0276 | 0.0276 |
Loa Loa (eye worm) | hypothetical protein | 0.0078 | 0.0276 | 0.027 |
Schistosoma mansoni | peptide (FMRFamide/somatostatin)-like receptor | 0.0078 | 0.0276 | 0.0276 |
Brugia malayi | gonadotropin-releasing hormone receptor 2 | 0.0078 | 0.0276 | 0.0276 |
Loa Loa (eye worm) | hypothetical protein | 0.0078 | 0.0276 | 0.027 |
Brugia malayi | ORL1-like opioid receptor | 0.0078 | 0.0276 | 0.0276 |
Brugia malayi | Dopamine receptor protein 1 | 0.0078 | 0.0276 | 0.0276 |
Loa Loa (eye worm) | G-protein coupled receptor | 0.0078 | 0.0276 | 0.027 |
Loa Loa (eye worm) | hypothetical protein | 0.0078 | 0.0276 | 0.027 |
Loa Loa (eye worm) | hypothetical protein | 0.0078 | 0.0276 | 0.027 |
Loa Loa (eye worm) | neuropeptide F receptor | 0.0078 | 0.0276 | 0.027 |
Schistosoma mansoni | ancient conserved domain protein 2 (cyclin m2) | 0.0078 | 0.0276 | 0.0276 |
Loa Loa (eye worm) | hypothetical protein | 0.0078 | 0.0276 | 0.027 |
Onchocerca volvulus | 0.0078 | 0.0276 | 1 | |
Brugia malayi | putative neuropeptide receptor NPR1 | 0.0078 | 0.0276 | 0.0276 |
Onchocerca volvulus | 0.0078 | 0.0276 | 1 | |
Echinococcus granulosus | calcium:calmodulin dependent 3'5' cyclic | 0.0343 | 0.3053 | 0.2855 |
Schistosoma mansoni | hypothetical protein | 0.0078 | 0.0276 | 0.0276 |
Onchocerca volvulus | 0.0078 | 0.0276 | 1 | |
Brugia malayi | Dopamine receptor protein 1, putative (partial) | 0.0078 | 0.0276 | 0.0276 |
Schistosoma mansoni | rhodopsin-like orphan GPCR | 0.0078 | 0.0276 | 0.0276 |
Echinococcus granulosus | survival motor neuron protein 1 | 0.0256 | 0.2134 | 0.191 |
Trypanosoma cruzi | cAMP phosphodiesterase A, putative | 0.0343 | 0.3053 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0078 | 0.0276 | 0.027 |
Brugia malayi | AKH receptor | 0.0078 | 0.0276 | 0.0276 |
Loa Loa (eye worm) | hypothetical protein | 0.0078 | 0.0276 | 0.027 |
Echinococcus granulosus | calcium:calmodulin dependent 3'5' cyclic | 0.1006 | 1 | 1 |
Schistosoma mansoni | neuropeptide F-like receptor | 0.0078 | 0.0276 | 0.0276 |
Loa Loa (eye worm) | hypothetical protein | 0.0078 | 0.0276 | 0.027 |
Brugia malayi | putative neuropeptide receptor | 0.0078 | 0.0276 | 0.0276 |
Loa Loa (eye worm) | hypothetical protein | 0.0078 | 0.0276 | 0.027 |
Brugia malayi | G protein-coupled receptor F59B2.13 | 0.0078 | 0.0276 | 0.0276 |
Onchocerca volvulus | 0.0078 | 0.0276 | 1 | |
Loa Loa (eye worm) | hypothetical protein | 0.0078 | 0.0276 | 0.027 |
Loa Loa (eye worm) | hypothetical protein | 0.0078 | 0.0276 | 0.027 |
Loa Loa (eye worm) | gonadotropin-releasing hormone receptor 2 | 0.0078 | 0.0276 | 0.027 |
Brugia malayi | G-protein coupled receptor | 0.0078 | 0.0276 | 0.0276 |
Echinococcus multilocularis | survival motor neuron protein 1 | 0.0256 | 0.2134 | 0.191 |
Schistosoma mansoni | growth hormone secretagogue receptor | 0.0078 | 0.0276 | 0.0276 |
Schistosoma mansoni | neuropeptide f receptor 76f | 0.0078 | 0.0276 | 0.0276 |
Schistosoma mansoni | opsin-like receptor | 0.0078 | 0.0276 | 0.0276 |
Loa Loa (eye worm) | hypothetical protein | 0.0078 | 0.0276 | 0.027 |
Schistosoma mansoni | rhodopsin-like orphan GPCR | 0.0078 | 0.0276 | 0.0276 |
Schistosoma mansoni | neuropeptide receptor | 0.0078 | 0.0276 | 0.0276 |
Leishmania major | cAMP phosphodiesterase A, putative;with=GeneDB:LinJ18_V3.1100 | 0.0343 | 0.3053 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0078 | 0.0276 | 0.027 |
Brugia malayi | GnHR receptor homolog | 0.0078 | 0.0276 | 0.0276 |
Loa Loa (eye worm) | hypothetical protein | 0.0078 | 0.0276 | 0.027 |
Onchocerca volvulus | 0.0078 | 0.0276 | 1 | |
Schistosoma mansoni | myosin xvIII | 0.0078 | 0.0276 | 0.0276 |
Loa Loa (eye worm) | neuropeptide F receptor | 0.0078 | 0.0276 | 0.027 |
Loa Loa (eye worm) | hypothetical protein | 0.0078 | 0.0276 | 0.027 |
Toxoplasma gondii | 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein | 0.0343 | 0.3053 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0078 | 0.0276 | 0.027 |
Schistosoma mansoni | rhodopsin-like orphan GPCR | 0.0078 | 0.0276 | 0.0276 |
Schistosoma mansoni | opsin-like receptor | 0.0078 | 0.0276 | 0.0276 |
Echinococcus multilocularis | calcium:calmodulin dependent 3',5' cyclic | 0.1006 | 1 | 1 |
Schistosoma mansoni | neuropeptide receptor | 0.0078 | 0.0276 | 0.0276 |
Schistosoma mansoni | biogenic amine (octopamine/dopamine) receptor | 0.0078 | 0.0276 | 0.0276 |
Loa Loa (eye worm) | hypothetical protein | 0.0078 | 0.0276 | 0.027 |
Schistosoma mansoni | opsin-like receptor | 0.0078 | 0.0276 | 0.0276 |
Loa Loa (eye worm) | hypothetical protein | 0.0078 | 0.0276 | 0.027 |
Schistosoma mansoni | neuropeptide receptor | 0.0078 | 0.0276 | 0.0276 |
Loa Loa (eye worm) | hypothetical protein | 0.0078 | 0.0276 | 0.027 |
Brugia malayi | G protein-coupled receptor | 0.0078 | 0.0276 | 0.0276 |
Schistosoma mansoni | histamine-responsive GPCR (AAF21638) | 0.0078 | 0.0276 | 0.0276 |
Schistosoma mansoni | rhodopsin-like orphan GPCR | 0.0078 | 0.0276 | 0.0276 |
Onchocerca volvulus | 0.0078 | 0.0276 | 1 | |
Loa Loa (eye worm) | G-protein coupled receptor | 0.0078 | 0.0276 | 0.027 |
Loa Loa (eye worm) | hypothetical protein | 0.0078 | 0.0276 | 0.027 |
Loa Loa (eye worm) | hypothetical protein | 0.0256 | 0.2134 | 0.2128 |
Brugia malayi | RE15519p | 0.0078 | 0.0276 | 0.0276 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0053 | 0.0007 | 0.0007 |
Schistosoma mansoni | alpha-1 adrenergic receptor | 0.0078 | 0.0276 | 0.0276 |
Loa Loa (eye worm) | hypothetical protein | 0.0078 | 0.0276 | 0.027 |
Schistosoma mansoni | biogenic amine receptor | 0.0078 | 0.0276 | 0.0276 |
Onchocerca volvulus | Dopamine\/Ecdysteroid receptor homolog | 0.0078 | 0.0276 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0078 | 0.0276 | 0.027 |
Loa Loa (eye worm) | PDE1B protein | 0.1006 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0078 | 0.0276 | 0.027 |
Schistosoma mansoni | amine GPCR | 0.0078 | 0.0276 | 0.0276 |
Schistosoma mansoni | rhodopsin-like orphan GPCR | 0.0078 | 0.0276 | 0.0276 |
Loa Loa (eye worm) | hypothetical protein | 0.0078 | 0.0276 | 0.027 |
Echinococcus multilocularis | atpase aaa+ type core atpase aaa type core | 0.0859 | 0.8458 | 0.8414 |
Onchocerca volvulus | Neuropeptide F receptor homolog | 0.0078 | 0.0276 | 1 |
Schistosoma mansoni | rhodopsin-like orphan GPCR | 0.0078 | 0.0276 | 0.0276 |
Loa Loa (eye worm) | hypothetical protein | 0.0078 | 0.0276 | 0.027 |
Brugia malayi | larval opioid receptor | 0.0078 | 0.0276 | 0.0276 |
Loa Loa (eye worm) | hypothetical protein | 0.0078 | 0.0276 | 0.027 |
Schistosoma mansoni | peptide (allatostatin/somatostatin)-like receptor | 0.0078 | 0.0276 | 0.0276 |
Loa Loa (eye worm) | hypothetical protein | 0.0078 | 0.0276 | 0.027 |
Onchocerca volvulus | 0.0078 | 0.0276 | 1 | |
Brugia malayi | Tachykinin-like peptides receptor 99D | 0.0078 | 0.0276 | 0.0276 |
Schistosoma mansoni | muscarinic acetylcholine (GAR) receptor | 0.0078 | 0.0276 | 0.0276 |
Onchocerca volvulus | 0.0078 | 0.0276 | 1 | |
Onchocerca volvulus | 0.0078 | 0.0276 | 1 | |
Loa Loa (eye worm) | G-protein-linked acetylcholine receptor protein 2 | 0.0078 | 0.0276 | 0.027 |
Brugia malayi | sulfakinin receptor protein | 0.0078 | 0.0276 | 0.0276 |
Brugia malayi | G-protein coupled receptor | 0.0078 | 0.0276 | 0.0276 |
Brugia malayi | hypothetical protein | 0.0078 | 0.0276 | 0.0276 |
Schistosoma mansoni | biogenic amine (5HT) receptor | 0.0078 | 0.0276 | 0.0276 |
Loa Loa (eye worm) | hypothetical protein | 0.0078 | 0.0276 | 0.027 |
Schistosoma mansoni | amine GPCR | 0.0078 | 0.0276 | 0.0276 |
Brugia malayi | hypothetical protein | 0.0256 | 0.2134 | 0.2134 |
Schistosoma mansoni | thyrotropin-releasing hormone receptor | 0.0078 | 0.0276 | 0.0276 |
Schistosoma mansoni | biogenic amine receptor | 0.0078 | 0.0276 | 0.0276 |
Echinococcus multilocularis | calcium:calmodulin dependent 3',5' cyclic | 0.0343 | 0.3053 | 0.2855 |
Schistosoma mansoni | biogenic amine receptor | 0.0078 | 0.0276 | 0.0276 |
Loa Loa (eye worm) | hypothetical protein | 0.0078 | 0.0276 | 0.027 |
Brugia malayi | Serotonin receptor | 0.0078 | 0.0276 | 0.0276 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | = 0.3 uM | Concentration required to reduce by 50% the amount of lipid peroxide formed in rat liver microsomes | ChEMBL. | 9046347 |
ID50 (functional) | = 21.9 mg kg-1 | Peroral dose required to reduce by 50% the score of excitatory behavior induced by intrathecal injection of ferrous chloride in mice | ChEMBL. | 9046347 |
ID50 (functional) | = 21.9 mg kg-1 | Peroral dose required to reduce by 50% the score of excitatory behavior induced by intrathecal injection of ferrous chloride in mice | ChEMBL. | 9046347 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.