Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (functional) | = 50 % | Percent anticonvulsant activity of the compound against pentylenetetrazole (PTZ)-induced attacks at 3 mg/kg peroral dose | ChEMBL. | 12477354 |
Activity (functional) | = 50 % | Percent anticonvulsant activity of the compound against pentylenetetrazole (PTZ)-induced attacks at 3 mg/kg peroral dose | ChEMBL. | 12477354 |
No. of falls (functional) | = 0.3 | Motor coordination of mouse as number of falls in 30 sec was reported after 3 mg/kg peroral dose using rotorod test | ChEMBL. | 12477354 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.