Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | = 67 uM | Tested for inhibition of L1210 mouse leukemia cell growth in culture | ChEMBL. | 2918503 |
IC50 (functional) | = 67 uM | Tested for inhibition of L1210 mouse leukemia cell growth in culture | ChEMBL. | 2918503 |
Ratio (binding) | = 10 | Tested for inhibition of thymidylate synthase from L1210 mouse leukemia cells expressed as ratio of I50 of compound to I50 of 1a (IRP= inverse relative potency) | ChEMBL. | 2918503 |
Ratio (binding) | = 10 | Tested for inhibition of thymidylate synthase from L1210 mouse leukemia cells expressed as ratio of I50 of compound to I50 of 1a (IRP= inverse relative potency) | ChEMBL. | 2918503 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.