Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | acetylcholinesterase | 0.2141 | 0.5 | 0.5 |
Echinococcus multilocularis | carboxylesterase 5A | 0.2141 | 0.5 | 0.5 |
Loa Loa (eye worm) | carboxylesterase | 0.2141 | 0.5 | 0.5 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.2141 | 0.5 | 0.5 |
Brugia malayi | Carboxylesterase family protein | 0.2141 | 0.5 | 0.5 |
Echinococcus multilocularis | acetylcholinesterase | 0.2141 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.2141 | 0.5 | 0.5 |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.2141 | 0.5 | 0.5 |
Echinococcus granulosus | carboxylesterase 5A | 0.2141 | 0.5 | 0.5 |
Echinococcus granulosus | acetylcholinesterase | 0.2141 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.2141 | 0.5 | 0.5 |
Echinococcus granulosus | acetylcholinesterase | 0.2141 | 0.5 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
ED50 (functional) | = 21 mg kg-1 | Compound was tested for anticonvulsant potency using the intravenous-BIC (bicuculline) test in mice; compound at 200 mg/kg induced impaired gait, loss of the righting reflex, and impaired breathing | ChEMBL. | 9484507 |
ED50 (functional) | = 21 mg kg-1 | Compound was tested for anticonvulsant potency using the intravenous-BIC (bicuculline) test in mice; compound at 200 mg/kg induced impaired gait, loss of the righting reflex, and impaired breathing | ChEMBL. | 9484507 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.