Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | Pyruvate dehydrogenase (lipoamide) kinase | 0.0262 | 0.8095 | 0.5 |
Leishmania major | developmentally regulated phosphoprotein-like protein | 0.0262 | 0.8095 | 0.8095 |
Echinococcus granulosus | Pyruvate dehydrogenase lipoamide kinase | 0.0262 | 0.8095 | 0.5 |
Toxoplasma gondii | ATPase/histidine kinase/DNA gyrase B/HSP90 domain-containing protein | 0.0106 | 0.0692 | 1 |
Brugia malayi | kinase, mitochondrial precursor | 0.0262 | 0.8095 | 0.5 |
Echinococcus multilocularis | Pyruvate dehydrogenase (lipoamide) kinase | 0.0262 | 0.8095 | 0.5 |
Trypanosoma brucei | developmentally regulated phosphoprotein | 0.0262 | 0.8095 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0262 | 0.8095 | 0.5 |
Trypanosoma cruzi | developmentally regulated phosphoprotein, putative | 0.0262 | 0.8095 | 1 |
Schistosoma mansoni | pyruvate dehydrogenase | 0.0262 | 0.8095 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
MIC (functional) | = 0.1 ug ml-1 | Antifungal activity towards Trichophyton mentagrophytes 530324 strain | ChEMBL. | 3546691 |
MIC (functional) | = 0.1 ug ml-1 | Antifungal activity towards Trichophyton interdigitale | ChEMBL. | 3546691 |
MIC (functional) | = 0.39 ug ml-1 | Antifungal activity against Aspergillus fumigatus Saito strain | ChEMBL. | 3546691 |
MIC (functional) | = 12.5 ug ml-1 | Antifungal activity against Candida albicans C-A-24 strain | ChEMBL. | 3546691 |
MIC (functional) | = 12.5 ug ml-1 | Antifungal activity against Candida albicans C-A-24 strain | ChEMBL. | 3546691 |
MIC (functional) | > 25 ug ml-1 | Antifungal activity against Cryptococcus neoformans Cr-1 strain | ChEMBL. | 3546691 |
MIC (functional) | > 25 ug ml-1 | Antifungal activity against Cryptococcus neoformans Cr-1 strain | ChEMBL. | 3546691 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.