Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.0046 | 0.4377 | 0.4377 |
Loa Loa (eye worm) | RNA binding protein | 0.007 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0046 | 0.4377 | 0.4377 |
Loa Loa (eye worm) | hypothetical protein | 0.0046 | 0.4377 | 0.4377 |
Loa Loa (eye worm) | hypothetical protein | 0.0046 | 0.4377 | 0.4377 |
Brugia malayi | neuropeptide F receptor | 0.0046 | 0.4377 | 0.4377 |
Loa Loa (eye worm) | hypothetical protein | 0.0046 | 0.4377 | 0.4377 |
Loa Loa (eye worm) | hypothetical protein | 0.0046 | 0.4377 | 0.4377 |
Loa Loa (eye worm) | hypothetical protein | 0.0046 | 0.4377 | 0.4377 |
Brugia malayi | hypothetical protein | 0.0046 | 0.4377 | 0.4377 |
Loa Loa (eye worm) | hypothetical protein | 0.0046 | 0.4377 | 0.4377 |
Loa Loa (eye worm) | hypothetical protein | 0.0046 | 0.4377 | 0.4377 |
Onchocerca volvulus | Dopamine\/Ecdysteroid receptor homolog | 0.0046 | 0.4377 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0046 | 0.4377 | 0.4377 |
Brugia malayi | G-protein-linked acetylcholine receptor protein 2, putative | 0.0046 | 0.4377 | 0.4377 |
Onchocerca volvulus | 0.0046 | 0.4377 | 0.5 | |
Leishmania major | hypothetical protein, conserved | 0.0028 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0046 | 0.4377 | 0.4377 |
Loa Loa (eye worm) | G-protein coupled receptor | 0.0046 | 0.4377 | 0.4377 |
Schistosoma mansoni | tar DNA-binding protein | 0.007 | 1 | 1 |
Loa Loa (eye worm) | G-protein coupled receptor | 0.0046 | 0.4377 | 0.4377 |
Onchocerca volvulus | 0.0046 | 0.4377 | 0.5 | |
Loa Loa (eye worm) | TYRA-2 protein | 0.0046 | 0.4377 | 0.4377 |
Schistosoma mansoni | tar DNA-binding protein | 0.007 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0046 | 0.4377 | 0.4377 |
Onchocerca volvulus | 0.0046 | 0.4377 | 0.5 | |
Loa Loa (eye worm) | hypothetical protein | 0.0046 | 0.4377 | 0.4377 |
Onchocerca volvulus | 0.0046 | 0.4377 | 0.5 | |
Onchocerca volvulus | 0.0046 | 0.4377 | 0.5 | |
Brugia malayi | Dopamine receptor protein 2 | 0.0046 | 0.4377 | 0.4377 |
Loa Loa (eye worm) | G-protein-linked acetylcholine receptor protein 2 | 0.0046 | 0.4377 | 0.4377 |
Onchocerca volvulus | 0.0046 | 0.4377 | 0.5 | |
Schistosoma mansoni | tar DNA-binding protein | 0.007 | 1 | 1 |
Brugia malayi | GnHR receptor homolog | 0.0046 | 0.4377 | 0.4377 |
Brugia malayi | TAR-binding protein | 0.007 | 1 | 1 |
Brugia malayi | Melatonin receptor type 1A | 0.0046 | 0.4377 | 0.4377 |
Loa Loa (eye worm) | hypothetical protein | 0.0046 | 0.4377 | 0.4377 |
Onchocerca volvulus | 0.0046 | 0.4377 | 0.5 | |
Onchocerca volvulus | 0.0046 | 0.4377 | 0.5 | |
Brugia malayi | putative neuropeptide receptor | 0.0046 | 0.4377 | 0.4377 |
Loa Loa (eye worm) | hypothetical protein | 0.0046 | 0.4377 | 0.4377 |
Loa Loa (eye worm) | hypothetical protein | 0.0046 | 0.4377 | 0.4377 |
Loa Loa (eye worm) | hypothetical protein | 0.0046 | 0.4377 | 0.4377 |
Loa Loa (eye worm) | unidentified vitellogenin-linked transcript protein 6 | 0.0046 | 0.4377 | 0.4377 |
Onchocerca volvulus | 0.0046 | 0.4377 | 0.5 | |
Brugia malayi | ORL1-like opioid receptor | 0.0046 | 0.4377 | 0.4377 |
Onchocerca volvulus | 0.0046 | 0.4377 | 0.5 | |
Loa Loa (eye worm) | hypothetical protein | 0.0046 | 0.4377 | 0.4377 |
Onchocerca volvulus | 0.0046 | 0.4377 | 0.5 | |
Brugia malayi | AKH receptor | 0.0046 | 0.4377 | 0.4377 |
Brugia malayi | G protein-coupled receptor | 0.0046 | 0.4377 | 0.4377 |
Brugia malayi | Dopamine receptor protein 1 | 0.0046 | 0.4377 | 0.4377 |
Brugia malayi | putative neuropeptide receptor NPR1 | 0.0046 | 0.4377 | 0.4377 |
Loa Loa (eye worm) | hypothetical protein | 0.0046 | 0.4377 | 0.4377 |
Loa Loa (eye worm) | TAR-binding protein | 0.007 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0046 | 0.4377 | 0.4377 |
Loa Loa (eye worm) | hypothetical protein | 0.0046 | 0.4377 | 0.4377 |
Echinococcus multilocularis | tar DNA binding protein | 0.007 | 1 | 1 |
Toxoplasma gondii | LsmAD domain-containing protein | 0.0028 | 0 | 0.5 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0028 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0046 | 0.4377 | 0.4377 |
Onchocerca volvulus | 0.0046 | 0.4377 | 0.5 | |
Loa Loa (eye worm) | neuropeptide F receptor | 0.0046 | 0.4377 | 0.4377 |
Brugia malayi | Dopamine receptor | 0.0046 | 0.4377 | 0.4377 |
Brugia malayi | RNA recognition motif domain containing protein | 0.007 | 1 | 1 |
Loa Loa (eye worm) | neuropeptide F receptor | 0.0046 | 0.4377 | 0.4377 |
Brugia malayi | hypothetical protein | 0.0046 | 0.4377 | 0.4377 |
Loa Loa (eye worm) | hypothetical protein | 0.0046 | 0.4377 | 0.4377 |
Brugia malayi | hypothetical protein | 0.0046 | 0.4377 | 0.4377 |
Loa Loa (eye worm) | hypothetical protein | 0.0046 | 0.4377 | 0.4377 |
Brugia malayi | Tachykinin-like peptides receptor 99D | 0.0046 | 0.4377 | 0.4377 |
Loa Loa (eye worm) | melatonin receptor type 1A | 0.0046 | 0.4377 | 0.4377 |
Brugia malayi | G protein-coupled receptor F59B2.13 | 0.0046 | 0.4377 | 0.4377 |
Brugia malayi | larval opioid receptor | 0.0046 | 0.4377 | 0.4377 |
Brugia malayi | Serotonin receptor | 0.0046 | 0.4377 | 0.4377 |
Loa Loa (eye worm) | hypothetical protein | 0.0046 | 0.4377 | 0.4377 |
Brugia malayi | RE15519p | 0.0046 | 0.4377 | 0.4377 |
Brugia malayi | gonadotropin-releasing hormone receptor 2 | 0.0046 | 0.4377 | 0.4377 |
Loa Loa (eye worm) | hypothetical protein | 0.0046 | 0.4377 | 0.4377 |
Schistosoma mansoni | tar DNA-binding protein | 0.007 | 1 | 1 |
Brugia malayi | G-protein coupled receptor | 0.0046 | 0.4377 | 0.4377 |
Brugia malayi | hypothetical protein | 0.0046 | 0.4377 | 0.4377 |
Loa Loa (eye worm) | hypothetical protein | 0.0046 | 0.4377 | 0.4377 |
Brugia malayi | hypothetical protein | 0.0046 | 0.4377 | 0.4377 |
Brugia malayi | G-protein coupled receptor | 0.0046 | 0.4377 | 0.4377 |
Loa Loa (eye worm) | hypothetical protein | 0.0046 | 0.4377 | 0.4377 |
Loa Loa (eye worm) | hypothetical protein | 0.0046 | 0.4377 | 0.4377 |
Brugia malayi | hypothetical protein | 0.0046 | 0.4377 | 0.4377 |
Echinococcus granulosus | tar DNA binding protein | 0.007 | 1 | 1 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.007 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0046 | 0.4377 | 0.4377 |
Brugia malayi | Serotonin/octopamine receptor family protein 7 | 0.0046 | 0.4377 | 0.4377 |
Onchocerca volvulus | 0.0046 | 0.4377 | 0.5 | |
Loa Loa (eye worm) | 5-hydroxytryptamine 2C receptor | 0.0046 | 0.4377 | 0.4377 |
Loa Loa (eye worm) | hypothetical protein | 0.0046 | 0.4377 | 0.4377 |
Plasmodium vivax | ataxin-2 like protein, putative | 0.0028 | 0 | 0.5 |
Onchocerca volvulus | 0.0046 | 0.4377 | 0.5 | |
Loa Loa (eye worm) | hypothetical protein | 0.0046 | 0.4377 | 0.4377 |
Onchocerca volvulus | Neuropeptide F receptor homolog | 0.0046 | 0.4377 | 0.5 |
Brugia malayi | hypothetical protein | 0.0046 | 0.4377 | 0.4377 |
Loa Loa (eye worm) | hypothetical protein | 0.0046 | 0.4377 | 0.4377 |
Loa Loa (eye worm) | hypothetical protein | 0.0046 | 0.4377 | 0.4377 |
Loa Loa (eye worm) | hypothetical protein | 0.0046 | 0.4377 | 0.4377 |
Brugia malayi | hypothetical protein | 0.0046 | 0.4377 | 0.4377 |
Trypanosoma brucei | PAB1-binding protein , putative | 0.0028 | 0 | 0.5 |
Brugia malayi | hypothetical protein | 0.0046 | 0.4377 | 0.4377 |
Loa Loa (eye worm) | follicle stimulating hormone receptor | 0.0046 | 0.4377 | 0.4377 |
Brugia malayi | neuropeptide F receptor | 0.0046 | 0.4377 | 0.4377 |
Brugia malayi | sulfakinin receptor protein | 0.0046 | 0.4377 | 0.4377 |
Brugia malayi | hypothetical protein | 0.0046 | 0.4377 | 0.4377 |
Loa Loa (eye worm) | hypothetical protein | 0.0046 | 0.4377 | 0.4377 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0028 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0046 | 0.4377 | 0.4377 |
Loa Loa (eye worm) | hypothetical protein | 0.0046 | 0.4377 | 0.4377 |
Loa Loa (eye worm) | hypothetical protein | 0.0046 | 0.4377 | 0.4377 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0028 | 0 | 0.5 |
Onchocerca volvulus | 0.0046 | 0.4377 | 0.5 | |
Loa Loa (eye worm) | hypothetical protein | 0.0046 | 0.4377 | 0.4377 |
Schistosoma mansoni | tar DNA-binding protein | 0.007 | 1 | 1 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0028 | 0 | 0.5 |
Onchocerca volvulus | 0.0046 | 0.4377 | 0.5 | |
Brugia malayi | follicle stimulating hormone receptor | 0.0046 | 0.4377 | 0.4377 |
Brugia malayi | Unidentified vitellogenin-linked transcript protein 6, putative | 0.0046 | 0.4377 | 0.4377 |
Onchocerca volvulus | 0.0046 | 0.4377 | 0.5 | |
Loa Loa (eye worm) | hypothetical protein | 0.0046 | 0.4377 | 0.4377 |
Brugia malayi | Serotonin receptor | 0.0046 | 0.4377 | 0.4377 |
Brugia malayi | Dopamine receptor protein 1, putative (partial) | 0.0046 | 0.4377 | 0.4377 |
Loa Loa (eye worm) | hypothetical protein | 0.0046 | 0.4377 | 0.4377 |
Loa Loa (eye worm) | hypothetical protein | 0.0046 | 0.4377 | 0.4377 |
Loa Loa (eye worm) | hypothetical protein | 0.0046 | 0.4377 | 0.4377 |
Loa Loa (eye worm) | hypothetical protein | 0.0046 | 0.4377 | 0.4377 |
Loa Loa (eye worm) | gonadotropin-releasing hormone receptor 2 | 0.0046 | 0.4377 | 0.4377 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
ED50 (functional) | = 0.26 mM kg-1 | Anticonvulsive activity in picrotoxin (PCR) induced seizure test | ChEMBL. | 10762036 |
ED50 (functional) | = 0.26 mM kg-1 | Anticonvulsive activity in picrotoxin (PCR) induced seizure test | ChEMBL. | 10762036 |
ED50 (functional) | = 0.31 mM kg-1 | Effective dose required for anticonvulsive activity of the compound in bicuculline (BIC) test | ChEMBL. | 10762036 |
ED50 (functional) | = 0.31 mM kg-1 | Effective dose required for anticonvulsive activity of the compound in bicuculline (BIC) test | ChEMBL. | 10762036 |
ED50 (functional) | = 0.41 mM kg-1 | Effective dose required for anticonvulsive activity of the compound in pentylenetetrazole (PTZ) test | ChEMBL. | 10762036 |
ED50 (functional) | = 0.41 mM kg-1 | Effective dose required for anticonvulsive activity of the compound in pentylenetetrazole (PTZ) test | ChEMBL. | 10762036 |
ED50 (functional) | > 0.54 mM kg-1 | Effective dose required for anticonvulsive activity of the compound in maximal electroshock seizure (MES) test | ChEMBL. | 10762036 |
ED50 (functional) | > 0.54 mM kg-1 | Effective dose required for anticonvulsive activity of the compound in maximal electroshock seizure (MES) test | ChEMBL. | 10762036 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.