Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma cruzi | polypeptide deformylase-like protein, putative | 0.0466 | 0.3591 | 1 |
Trypanosoma cruzi | histone deacetylase, putative | 0.0055 | 0.0102 | 0.0284 |
Trichomonas vaginalis | histone deacetylase, putative | 0.0043 | 0 | 0.5 |
Entamoeba histolytica | histone deacetylase, putative | 0.0043 | 0 | 0.5 |
Brugia malayi | Histone deacetylase family protein | 0.0055 | 0.0102 | 1 |
Echinococcus multilocularis | histone deacetylase 6 | 0.0055 | 0.0102 | 1 |
Plasmodium falciparum | peptide deformylase | 0.1222 | 1 | 1 |
Echinococcus granulosus | histone deacetylase 6 | 0.0055 | 0.0102 | 1 |
Plasmodium falciparum | histone deacetylase 2 | 0.0055 | 0.0102 | 0.0102 |
Trichomonas vaginalis | histone deacetylase, putative | 0.0043 | 0 | 0.5 |
Trichomonas vaginalis | histone deacetylase 1, 2 ,3, putative | 0.0043 | 0 | 0.5 |
Trypanosoma brucei | Polypeptide deformylase 1 | 0.0466 | 0.3591 | 1 |
Echinococcus multilocularis | histone deacetylase 6 | 0.0055 | 0.0102 | 1 |
Echinococcus multilocularis | histone deacetylase 6 | 0.0055 | 0.0102 | 1 |
Trypanosoma cruzi | Peptide deformylase 2, putative | 0.0466 | 0.3591 | 1 |
Plasmodium vivax | histone deacetylase, putative | 0.0055 | 0.0102 | 0.0102 |
Trichomonas vaginalis | histone deacetylase, putative | 0.0043 | 0 | 0.5 |
Echinococcus granulosus | histone deacetylase 7 | 0.0055 | 0.0102 | 1 |
Trypanosoma brucei | histone deacetylase 4 | 0.0055 | 0.0102 | 0.0284 |
Plasmodium falciparum | histone deacetylase, putative | 0.0055 | 0.0102 | 0.0102 |
Giardia lamblia | Histone deacetylase | 0.0043 | 0 | 0.5 |
Schistosoma mansoni | histone deacetylase hda2 | 0.0055 | 0.0102 | 1 |
Trypanosoma brucei | histone deacetylase 3 | 0.0055 | 0.0102 | 0.0284 |
Brugia malayi | Histone deacetylase family protein | 0.0055 | 0.0102 | 1 |
Mycobacterium leprae | PROBABLE POLYPEPTIDE DEFORMYLASE DEF (PDF) (FORMYLMETHIONINE DEFORMYLASE) | 0.1222 | 1 | 0.5 |
Trypanosoma brucei | histone deacetylase, putative | 0.0055 | 0.0102 | 0.0284 |
Echinococcus multilocularis | histone deacetylase | 0.0055 | 0.0102 | 1 |
Echinococcus multilocularis | histone deacetylase 7 | 0.0055 | 0.0102 | 1 |
Plasmodium vivax | histone deacetylase 2, putative | 0.0055 | 0.0102 | 0.0102 |
Schistosoma mansoni | histone deacetylase 4 5 | 0.0055 | 0.0102 | 1 |
Toxoplasma gondii | hypothetical protein | 0.1222 | 1 | 1 |
Leishmania major | histone deacetylase, putative | 0.0055 | 0.0102 | 0.0284 |
Trypanosoma cruzi | histone deacetylase, putative | 0.0055 | 0.0102 | 0.0284 |
Trichomonas vaginalis | histone deacetylase, putative | 0.0043 | 0 | 0.5 |
Loa Loa (eye worm) | histone deacetylase 7A | 0.0055 | 0.0102 | 1 |
Mycobacterium ulcerans | peptide deformylase | 0.1222 | 1 | 0.5 |
Schistosoma mansoni | histone deacetylase 4 5 | 0.0055 | 0.0102 | 1 |
Trypanosoma cruzi | histone deacetylase, putative | 0.0055 | 0.0102 | 0.0284 |
Trichomonas vaginalis | histone deacetylase 1, 2 ,3, putative | 0.0043 | 0 | 0.5 |
Echinococcus granulosus | histone deacetylase 6 | 0.0055 | 0.0102 | 1 |
Leishmania major | histone deacetylase, putative | 0.0055 | 0.0102 | 0.0284 |
Trypanosoma brucei | Peptide deformylase 2 | 0.0466 | 0.3591 | 1 |
Loa Loa (eye worm) | histone deacetylase | 0.0055 | 0.0102 | 1 |
Trichomonas vaginalis | histone deacetylase, putative | 0.0043 | 0 | 0.5 |
Trypanosoma cruzi | polypeptide deformylase-like protein, putative | 0.0466 | 0.3591 | 1 |
Trichomonas vaginalis | histone deacetylase 1, 2 ,3, putative | 0.0043 | 0 | 0.5 |
Leishmania major | polypeptide deformylase-like protein, putative | 0.0466 | 0.3591 | 1 |
Trypanosoma cruzi | Peptide deformylase 2, putative | 0.0466 | 0.3591 | 1 |
Echinococcus granulosus | histone deacetylase 6 | 0.0055 | 0.0102 | 1 |
Toxoplasma gondii | histone deacetylase HDAC1 | 0.0055 | 0.0102 | 0.0102 |
Echinococcus granulosus | histone deacetylase | 0.0055 | 0.0102 | 1 |
Plasmodium vivax | peptide deformylase, putative | 0.1222 | 1 | 1 |
Treponema pallidum | polypeptide deformylase (def) | 0.1222 | 1 | 0.5 |
Trichomonas vaginalis | histone deacetylase, putative | 0.0043 | 0 | 0.5 |
Mycobacterium tuberculosis | Probable polypeptide deformylase Def (PDF) (formylmethionine deformylase) | 0.1222 | 1 | 0.5 |
Wolbachia endosymbiont of Brugia malayi | peptide deformylase | 0.1222 | 1 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Inhibition (functional) | = 45.2 % | Antiallergic activity determined by passive cutaneous anaphylaxis assay upon peroral administration of 20 mg/kg in rat | ChEMBL. | 2465410 |
Inhibition (binding) | = 80.4 % | Inhibitory activity against 5-lipoxygenase at 10 microM | ChEMBL. | 2465410 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.