Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Escherichia coli | peptide deformylase | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Leishmania major | cytidine deaminase-like protein | 0.0526 | 1 | 1 |
Trypanosoma brucei | cytidine deaminase | 0.0526 | 1 | 1 |
Mycobacterium leprae | PROBABLE CYTIDINE DEAMINASE CDD (CYTIDINE AMINOHYDROLASE) (CYTIDINE NUCLEOSIDE DEAMINASE) | 0.0526 | 1 | 1 |
Mycobacterium tuberculosis | Probable cytidine deaminase Cdd (cytidine aminohydrolase) (cytidine nucleoside deaminase) | 0.0526 | 1 | 1 |
Echinococcus multilocularis | cytidine deaminase | 0.0526 | 1 | 0.5 |
Trypanosoma cruzi | cytidine deaminase-like protein | 0.0526 | 1 | 1 |
Toxoplasma gondii | cytidine and deoxycytidylate deaminase zinc-binding region domain-containing protein | 0.0526 | 1 | 1 |
Wolbachia endosymbiont of Brugia malayi | peptide deformylase | 0.0279 | 0.4111 | 0.5 |
Plasmodium vivax | peptide deformylase, putative | 0.0279 | 0.4111 | 0.5 |
Trichomonas vaginalis | cytidine deaminase, putative | 0.0526 | 1 | 0.5 |
Chlamydia trachomatis | peptide deformylase | 0.0279 | 0.4111 | 0.5 |
Treponema pallidum | polypeptide deformylase (def) | 0.0279 | 0.4111 | 0.5 |
Echinococcus granulosus | cytidine deaminase | 0.0526 | 1 | 0.5 |
Onchocerca volvulus | 0.0526 | 1 | 0.5 | |
Mycobacterium ulcerans | cytidine deaminase | 0.0526 | 1 | 1 |
Trypanosoma cruzi | cytidine deaminase-like protein, putative | 0.0526 | 1 | 1 |
Giardia lamblia | Cytidine deaminase | 0.0526 | 1 | 0.5 |
Entamoeba histolytica | cytidine deaminase, putative | 0.0526 | 1 | 0.5 |
Trichomonas vaginalis | cytidine deaminase, putative | 0.0526 | 1 | 0.5 |
Onchocerca volvulus | 0.0526 | 1 | 0.5 | |
Plasmodium falciparum | peptide deformylase | 0.0279 | 0.4111 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 8 nM | Inhibitory activity against Escherichia coli peptide deformylase (PDF) Nickel containing enzyme | ChEMBL. | 14684298 |
IC50 (binding) | = 8 nM | Inhibitory activity against Escherichia coli peptide deformylase (PDF) Nickel containing enzyme | ChEMBL. | 14684298 |
MIC (functional) | = 3.1 uM | Minimum inhibitory concentration required for primary screening against in-house strain of Staphylococcus capitis tested in vitro | ChEMBL. | 14684298 |
MIC (functional) | = 12 uM | Minimum inhibitory concentration required for primary screening against in-house strain of Escherichia coli tested in vitro | ChEMBL. | 14684298 |
MIC (functional) | = 12 uM | Minimum inhibitory concentration required for primary screening against in-house strain of Escherichia coli tested in vitro | ChEMBL. | 14684298 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.