Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Escherichia coli | peptide deformylase | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma brucei | cytidine deaminase | 0.0526 | 1 | 1 |
Mycobacterium tuberculosis | Probable cytidine deaminase Cdd (cytidine aminohydrolase) (cytidine nucleoside deaminase) | 0.0526 | 1 | 1 |
Onchocerca volvulus | 0.0526 | 1 | 0.5 | |
Toxoplasma gondii | cytidine and deoxycytidylate deaminase zinc-binding region domain-containing protein | 0.0526 | 1 | 1 |
Mycobacterium ulcerans | cytidine deaminase | 0.0526 | 1 | 1 |
Echinococcus multilocularis | cytidine deaminase | 0.0526 | 1 | 0.5 |
Plasmodium vivax | peptide deformylase, putative | 0.0279 | 0.4111 | 0.5 |
Leishmania major | cytidine deaminase-like protein | 0.0526 | 1 | 1 |
Wolbachia endosymbiont of Brugia malayi | peptide deformylase | 0.0279 | 0.4111 | 0.5 |
Trichomonas vaginalis | cytidine deaminase, putative | 0.0526 | 1 | 0.5 |
Treponema pallidum | polypeptide deformylase (def) | 0.0279 | 0.4111 | 0.5 |
Plasmodium falciparum | peptide deformylase | 0.0279 | 0.4111 | 0.5 |
Trichomonas vaginalis | cytidine deaminase, putative | 0.0526 | 1 | 0.5 |
Trypanosoma cruzi | cytidine deaminase-like protein, putative | 0.0526 | 1 | 1 |
Entamoeba histolytica | cytidine deaminase, putative | 0.0526 | 1 | 0.5 |
Trypanosoma cruzi | cytidine deaminase-like protein | 0.0526 | 1 | 1 |
Onchocerca volvulus | 0.0526 | 1 | 0.5 | |
Giardia lamblia | Cytidine deaminase | 0.0526 | 1 | 0.5 |
Chlamydia trachomatis | peptide deformylase | 0.0279 | 0.4111 | 0.5 |
Echinococcus granulosus | cytidine deaminase | 0.0526 | 1 | 0.5 |
Mycobacterium leprae | PROBABLE CYTIDINE DEAMINASE CDD (CYTIDINE AMINOHYDROLASE) (CYTIDINE NUCLEOSIDE DEAMINASE) | 0.0526 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 8 nM | Inhibitory activity against Escherichia coli peptide deformylase (PDF) Nickel containing enzyme | ChEMBL. | 14684298 |
IC50 (binding) | = 8 nM | Inhibitory activity against Escherichia coli peptide deformylase (PDF) Nickel containing enzyme | ChEMBL. | 14684298 |
MIC (functional) | = 3.1 uM | Minimum inhibitory concentration required for primary screening against in-house strain of Staphylococcus capitis tested in vitro | ChEMBL. | 14684298 |
MIC (functional) | = 12 uM | Minimum inhibitory concentration required for primary screening against in-house strain of Escherichia coli tested in vitro | ChEMBL. | 14684298 |
MIC (functional) | = 12 uM | Minimum inhibitory concentration required for primary screening against in-house strain of Escherichia coli tested in vitro | ChEMBL. | 14684298 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.