TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 603.768 | Formula: C32H50FN5O5
H donors: 2 H acceptors: 4 LogP: 4.5 Rotable bonds: 15
Rule of 5 violations (Lipinski): 2
SMILES: O=CN(C[C@H](C(=O)N[C@@H](C(C)(C)C)C(=O)c1ccc(c(c1)F)N1CCN(CC1)CCN1CCOCC1)CC1CCCC1)O
InChi: 1S/C32H50FN5O5/c1-32(2,3)30(34-31(41)26(22-38(42)23-39)20-24-6-4-5-7-24)29(40)25-8-9-28(27(33)21-25)37-14-12-35(13-15-37)10-11-36-16-18-43-19-17-36/h8-9,21,23-24,26,30,42H,4-7,10-20,22H2,1-3H3,(H,34,41)/t26-,30-/m1/s1
InChiKey: CTEVYPNDEWWZDP-PDDLMNHVSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Escherichia coli	peptide deformylase	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Toxoplasma gondii	hypothetical protein	Get druggable targets OG5_128237	All targets in OG5_128237
Plasmodium falciparum	peptide deformylase	Get druggable targets OG5_128237	All targets in OG5_128237
Plasmodium berghei	peptide deformylase, putative	Get druggable targets OG5_128237	All targets in OG5_128237
Mycobacterium ulcerans	peptide deformylase	Get druggable targets OG5_128237	All targets in OG5_128237
Neospora caninum	Peptide deformylase, related	Get druggable targets OG5_128237	All targets in OG5_128237
Mycobacterium leprae	PROBABLE POLYPEPTIDE DEFORMYLASE DEF (PDF) (FORMYLMETHIONINE DEFORMYLASE)	Get druggable targets OG5_128237	All targets in OG5_128237
Plasmodium knowlesi	peptide deformylase, putative	Get druggable targets OG5_128237	All targets in OG5_128237
Mycobacterium tuberculosis	Probable polypeptide deformylase Def (PDF) (formylmethionine deformylase)	Get druggable targets OG5_128237	All targets in OG5_128237
Treponema pallidum	polypeptide deformylase (def)	Get druggable targets OG5_128237	All targets in OG5_128237
Plasmodium vivax	peptide deformylase, putative	Get druggable targets OG5_128237	All targets in OG5_128237
Chlamydia trachomatis	peptide deformylase	Get druggable targets OG5_128237	All targets in OG5_128237
Plasmodium yoelii	polypeptide deformylase, putative	Get druggable targets OG5_128237	All targets in OG5_128237
Wolbachia endosymbiont of Brugia malayi	peptide deformylase	Get druggable targets OG5_128237	All targets in OG5_128237

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Schistosoma mansoni	biogenic amine receptor	0.0176	0	0.5
Brugia malayi	ORL1-like opioid receptor	0.0176	0	0.5
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0176	0	0.5
Echinococcus multilocularis	neuropeptide s receptor	0.0176	0	0.5
Echinococcus granulosus	rhodopsin orphan GPCR	0.0176	0	0.5
Loa Loa (eye worm)	hypothetical protein	0.0176	0	0.5
Loa Loa (eye worm)	hypothetical protein	0.0176	0	0.5
Loa Loa (eye worm)	5-hydroxytryptamine 2C receptor	0.0176	0	0.5
Echinococcus multilocularis	fmrfamide receptor	0.0176	0	0.5
Echinococcus granulosus	neuropeptide Y receptor	0.0176	0	0.5
Echinococcus granulosus	neuropeptides capa receptor	0.0176	0	0.5
Loa Loa (eye worm)	hypothetical protein	0.0176	0	0.5
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0176	0	0.5
Schistosoma mansoni	neuropeptide F-like receptor	0.0176	0	0.5
Plasmodium falciparum	peptide deformylase	0.0279	1	0.5
Echinococcus multilocularis	thyrotropin releasing hormone receptor	0.0176	0	0.5
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0176	0	0.5
Echinococcus multilocularis	allatostatin A receptor	0.0176	0	0.5
Echinococcus granulosus	biogenic amine 5HT receptor	0.0176	0	0.5
Echinococcus multilocularis	neuropeptide receptor A26	0.0176	0	0.5
Brugia malayi	hypothetical protein	0.0176	0	0.5
Loa Loa (eye worm)	gonadotropin-releasing hormone receptor 2	0.0176	0	0.5
Echinococcus granulosus	allatostatin A receptor	0.0176	0	0.5
Echinococcus granulosus	orexin receptor type 2	0.0176	0	0.5
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0176	0	0.5
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0176	0	0.5
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0176	0	0.5
Loa Loa (eye worm)	hypothetical protein	0.0176	0	0.5
Schistosoma mansoni	hypothetical protein	0.0176	0	0.5
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0176	0	0.5
Schistosoma mansoni	biogenic amine receptor	0.0176	0	0.5
Echinococcus multilocularis	serotonin receptor	0.0176	0	0.5
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0176	0	0.5
Schistosoma mansoni	thyrotropin-releasing hormone receptor	0.0176	0	0.5
Brugia malayi	AKH receptor	0.0176	0	0.5
Echinococcus granulosus	fmrfamide receptor	0.0176	0	0.5
Echinococcus granulosus	growth hormone secretagogue receptor type 1	0.0176	0	0.5
Echinococcus multilocularis	biogenic amine (5HT) receptor	0.0176	0	0.5
Brugia malayi	GnHR receptor homolog	0.0176	0	0.5
Onchocerca volvulus		0.0176	0	0.5
Loa Loa (eye worm)	hypothetical protein	0.0176	0	0.5
Onchocerca volvulus		0.0176	0	0.5
Echinococcus granulosus	neuropeptides capa receptor	0.0176	0	0.5
Loa Loa (eye worm)	hypothetical protein	0.0176	0	0.5
Brugia malayi	RE15519p	0.0176	0	0.5
Onchocerca volvulus		0.0176	0	0.5
Echinococcus granulosus	rhodopsin orphan GPCR	0.0176	0	0.5
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0176	0	0.5
Loa Loa (eye worm)	hypothetical protein	0.0176	0	0.5
Loa Loa (eye worm)	hypothetical protein	0.0176	0	0.5
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0176	0	0.5
Echinococcus granulosus	peptide allatostatin:somatostatin	0.0176	0	0.5
Loa Loa (eye worm)	hypothetical protein	0.0176	0	0.5
Schistosoma mansoni	opsin-like receptor	0.0176	0	0.5
Onchocerca volvulus		0.0176	0	0.5
Echinococcus granulosus	alpha 1A adrenergic receptor	0.0176	0	0.5
Echinococcus granulosus	dro:myosuppressin receptor	0.0176	0	0.5
Schistosoma mansoni	alpha-1 adrenergic receptor	0.0176	0	0.5
Schistosoma mansoni	neuropeptide f receptor 76f	0.0176	0	0.5
Brugia malayi	hypothetical protein	0.0176	0	0.5
Loa Loa (eye worm)	hypothetical protein	0.0176	0	0.5
Brugia malayi	Serotonin/octopamine receptor family protein 7	0.0176	0	0.5
Echinococcus granulosus	rhodopsin orphan GPCR	0.0176	0	0.5
Brugia malayi	hypothetical protein	0.0176	0	0.5
Echinococcus multilocularis	fmrfamide receptor	0.0176	0	0.5
Brugia malayi	follicle stimulating hormone receptor	0.0176	0	0.5
Loa Loa (eye worm)	hypothetical protein	0.0176	0	0.5
Brugia malayi	Dopamine receptor	0.0176	0	0.5
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0176	0	0.5
Loa Loa (eye worm)	hypothetical protein	0.0176	0	0.5
Brugia malayi	Unidentified vitellogenin-linked transcript protein 6, putative	0.0176	0	0.5
Echinococcus multilocularis	g protein coupled receptor	0.0176	0	0.5
Loa Loa (eye worm)	hypothetical protein	0.0176	0	0.5
Schistosoma mansoni	neuropeptide receptor	0.0176	0	0.5
Schistosoma mansoni	peptide (allatostatin/somatostatin)-like receptor	0.0176	0	0.5
Schistosoma mansoni	hypothetical protein	0.0176	0	0.5
Echinococcus multilocularis	serotonin receptor	0.0176	0	0.5
Brugia malayi	hypothetical protein	0.0176	0	0.5
Schistosoma mansoni	amine GPCR	0.0176	0	0.5
Brugia malayi	Serotonin receptor	0.0176	0	0.5
Echinococcus multilocularis	pyroglutamylated rfamide peptide receptor	0.0176	0	0.5
Echinococcus multilocularis	alpha 1A adrenergic receptor	0.0176	0	0.5
Loa Loa (eye worm)	G-protein coupled receptor	0.0176	0	0.5
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0176	0	0.5
Brugia malayi	Tachykinin-like peptides receptor 99D	0.0176	0	0.5
Echinococcus granulosus	rhodopsin orphan GPCR	0.0176	0	0.5
Brugia malayi	G protein-coupled receptor F59B2.13	0.0176	0	0.5
Brugia malayi	G-protein coupled receptor	0.0176	0	0.5
Loa Loa (eye worm)	unidentified vitellogenin-linked transcript protein 6	0.0176	0	0.5
Echinococcus granulosus	neuropeptide s receptor	0.0176	0	0.5
Onchocerca volvulus		0.0176	0	0.5
Loa Loa (eye worm)	hypothetical protein	0.0176	0	0.5
Loa Loa (eye worm)	G-protein-linked acetylcholine receptor protein 2	0.0176	0	0.5
Onchocerca volvulus		0.0176	0	0.5
Loa Loa (eye worm)	G-protein coupled receptor	0.0176	0	0.5
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0176	0	0.5
Loa Loa (eye worm)	hypothetical protein	0.0176	0	0.5
Schistosoma mansoni	amine GPCR	0.0176	0	0.5
Brugia malayi	hypothetical protein	0.0176	0	0.5
Brugia malayi	hypothetical protein	0.0176	0	0.5
Loa Loa (eye worm)	hypothetical protein	0.0176	0	0.5
Brugia malayi	hypothetical protein	0.0176	0	0.5
Echinococcus granulosus	sex peptide receptor	0.0176	0	0.5
Onchocerca volvulus		0.0176	0	0.5
Loa Loa (eye worm)	hypothetical protein	0.0176	0	0.5
Echinococcus multilocularis	somatostatin receptor	0.0176	0	0.5
Brugia malayi	putative neuropeptide receptor	0.0176	0	0.5
Echinococcus granulosus	G protein coupled 5 hydroxytryptamine receptor	0.0176	0	0.5
Loa Loa (eye worm)	hypothetical protein	0.0176	0	0.5
Echinococcus granulosus	G protein coupled receptor 139	0.0176	0	0.5
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0176	0	0.5
Brugia malayi	hypothetical protein	0.0176	0	0.5
Schistosoma mansoni	myosin xvIII	0.0176	0	0.5
Echinococcus granulosus	hypothetical protein	0.0176	0	0.5
Echinococcus multilocularis	neuropeptide FF receptor 2	0.0176	0	0.5
Echinococcus granulosus	7tm_1 domain containing protein	0.0176	0	0.5
Echinococcus multilocularis	dro:myosuppressin receptor	0.0176	0	0.5
Schistosoma mansoni	neuropeptide receptor	0.0176	0	0.5
Schistosoma mansoni	neuropeptide F-like receptor	0.0176	0	0.5
Onchocerca volvulus		0.0176	0	0.5
Brugia malayi	Dopamine receptor protein 2	0.0176	0	0.5
Schistosoma mansoni	hypothetical protein	0.0176	0	0.5
Schistosoma mansoni	amine GPCR	0.0176	0	0.5
Echinococcus granulosus	neuropeptide receptor	0.0176	0	0.5
Onchocerca volvulus		0.0176	0	0.5
Onchocerca volvulus		0.0176	0	0.5
Loa Loa (eye worm)	hypothetical protein	0.0176	0	0.5
Brugia malayi	sulfakinin receptor protein	0.0176	0	0.5
Echinococcus granulosus	serotonin receptor	0.0176	0	0.5
Schistosoma mansoni	ancient conserved domain protein 2 (cyclin m2)	0.0176	0	0.5
Echinococcus multilocularis	sex peptide receptor	0.0176	0	0.5
Echinococcus granulosus	thyrotropin releasing hormone receptor	0.0176	0	0.5
Echinococcus granulosus	tm gpcr rhodopsin	0.0176	0	0.5
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0176	0	0.5
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0176	0	0.5
Schistosoma mansoni	neuropeptide receptor	0.0176	0	0.5
Mycobacterium ulcerans	peptide deformylase	0.0279	1	0.5
Loa Loa (eye worm)	hypothetical protein	0.0176	0	0.5
Loa Loa (eye worm)	hypothetical protein	0.0176	0	0.5
Loa Loa (eye worm)	hypothetical protein	0.0176	0	0.5
Echinococcus multilocularis	g protein coupled receptor	0.0176	0	0.5
Brugia malayi	hypothetical protein	0.0176	0	0.5
Loa Loa (eye worm)	hypothetical protein	0.0176	0	0.5
Echinococcus granulosus	g protein coupled receptor	0.0176	0	0.5
Loa Loa (eye worm)	hypothetical protein	0.0176	0	0.5
Schistosoma mansoni	histamine-responsive GPCR (AAF21638)	0.0176	0	0.5
Loa Loa (eye worm)	hypothetical protein	0.0176	0	0.5
Loa Loa (eye worm)	hypothetical protein	0.0176	0	0.5
Loa Loa (eye worm)	hypothetical protein	0.0176	0	0.5
Loa Loa (eye worm)	TYRA-2 protein	0.0176	0	0.5
Schistosoma mansoni	opsin-like receptor	0.0176	0	0.5
Echinococcus granulosus	biogenic amine 5HT receptor	0.0176	0	0.5
Loa Loa (eye worm)	hypothetical protein	0.0176	0	0.5
Loa Loa (eye worm)	hypothetical protein	0.0176	0	0.5
Loa Loa (eye worm)	follicle stimulating hormone receptor	0.0176	0	0.5
Brugia malayi	Dopamine receptor protein 1, putative (partial)	0.0176	0	0.5
Echinococcus granulosus	somatostatin receptor	0.0176	0	0.5
Onchocerca volvulus	Dopamine\/Ecdysteroid receptor homolog	0.0176	0	0.5
Brugia malayi	Dopamine receptor protein 1	0.0176	0	0.5
Echinococcus granulosus	g protein coupled receptor	0.0176	0	0.5
Echinococcus granulosus	neuropeptide FF receptor 2	0.0176	0	0.5
Loa Loa (eye worm)	hypothetical protein	0.0176	0	0.5
Schistosoma mansoni	opsin-like receptor	0.0176	0	0.5
Echinococcus multilocularis	neuropeptides capa receptor	0.0176	0	0.5
Echinococcus granulosus	tachykinin peptides receptor 99D	0.0176	0	0.5
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0176	0	0.5
Mycobacterium tuberculosis	Probable polypeptide deformylase Def (PDF) (formylmethionine deformylase)	0.0279	1	0.5
Plasmodium vivax	peptide deformylase, putative	0.0279	1	0.5
Toxoplasma gondii	hypothetical protein	0.0279	1	0.5
Loa Loa (eye worm)	hypothetical protein	0.0176	0	0.5
Schistosoma mansoni	peptide (FMRFamide/neurokinin-3)-like receptor	0.0176	0	0.5
Loa Loa (eye worm)	hypothetical protein	0.0176	0	0.5
Echinococcus multilocularis	peptide (allatostatin:somatostatin)	0.0176	0	0.5
Schistosoma mansoni	peptide (allatostatin)-like receptor	0.0176	0	0.5
Echinococcus multilocularis	7TM GPCR, rhodopsin	0.0176	0	0.5
Schistosoma mansoni	adenoreceptor	0.0176	0	0.5
Loa Loa (eye worm)	hypothetical protein	0.0176	0	0.5
Echinococcus granulosus	7TM GPCR rhodopsin	0.0176	0	0.5
Mycobacterium leprae	PROBABLE POLYPEPTIDE DEFORMYLASE DEF (PDF) (FORMYLMETHIONINE DEFORMYLASE)	0.0279	1	0.5
Loa Loa (eye worm)	hypothetical protein	0.0176	0	0.5
Loa Loa (eye worm)	hypothetical protein	0.0176	0	0.5
Onchocerca volvulus		0.0176	0	0.5
Treponema pallidum	polypeptide deformylase (def)	0.0279	1	0.5
Loa Loa (eye worm)	hypothetical protein	0.0176	0	0.5
Loa Loa (eye worm)	neuropeptide F receptor	0.0176	0	0.5
Loa Loa (eye worm)	hypothetical protein	0.0176	0	0.5
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0176	0	0.5
Loa Loa (eye worm)	hypothetical protein	0.0176	0	0.5
Schistosoma mansoni	histamine h1 receptor	0.0176	0	0.5
Echinococcus multilocularis	orexin receptor type 2	0.0176	0	0.5
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0176	0	0.5
Onchocerca volvulus		0.0176	0	0.5
Brugia malayi	Melatonin receptor type 1A	0.0176	0	0.5
Schistosoma mansoni	amine GPCR	0.0176	0	0.5
Schistosoma mansoni	muscarinic acetylcholine (GAR) receptor	0.0176	0	0.5
Loa Loa (eye worm)	hypothetical protein	0.0176	0	0.5
Schistosoma mansoni	biogenic amine receptor	0.0176	0	0.5
Schistosoma mansoni	hypothetical protein	0.0176	0	0.5
Brugia malayi	larval opioid receptor	0.0176	0	0.5
Echinococcus granulosus	neuropeptide receptor A26	0.0176	0	0.5
Schistosoma mansoni	amine GPCR	0.0176	0	0.5
Brugia malayi	neuropeptide F receptor	0.0176	0	0.5
Echinococcus multilocularis	g protein coupled receptor	0.0176	0	0.5
Echinococcus multilocularis	G-protein coupled receptor, putative	0.0176	0	0.5
Echinococcus granulosus	rhodopsin orphan GPCR	0.0176	0	0.5
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0176	0	0.5
Onchocerca volvulus		0.0176	0	0.5
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0176	0	0.5
Echinococcus multilocularis	neuropeptide receptor	0.0176	0	0.5
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0176	0	0.5
Brugia malayi	gonadotropin-releasing hormone receptor 2	0.0176	0	0.5
Echinococcus multilocularis	g-protein coupled receptor	0.0176	0	0.5
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0176	0	0.5
Loa Loa (eye worm)	melatonin receptor type 1A	0.0176	0	0.5
Echinococcus multilocularis	neuropeptide Y receptor	0.0176	0	0.5
Loa Loa (eye worm)	hypothetical protein	0.0176	0	0.5
Schistosoma mansoni	biogenic amine (octopamine/dopamine) receptor	0.0176	0	0.5
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0176	0	0.5
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0176	0	0.5
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0176	0	0.5
Brugia malayi	G-protein coupled receptor	0.0176	0	0.5
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0176	0	0.5
Echinococcus granulosus	tm gpcr rhodopsin	0.0176	0	0.5
Brugia malayi	putative neuropeptide receptor NPR1	0.0176	0	0.5
Echinococcus multilocularis	neuropeptide receptor	0.0176	0	0.5
Echinococcus multilocularis	growth hormone secretagogue receptor type 1	0.0176	0	0.5
Echinococcus granulosus	pyroglutamylated rfamide peptide receptor	0.0176	0	0.5
Echinococcus multilocularis	tachykinin peptides receptor 99D	0.0176	0	0.5
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0176	0	0.5
Onchocerca volvulus		0.0176	0	0.5
Onchocerca volvulus		0.0176	0	0.5
Brugia malayi	Serotonin receptor	0.0176	0	0.5
Brugia malayi	neuropeptide F receptor	0.0176	0	0.5
Schistosoma mansoni	neuropeptide receptor	0.0176	0	0.5
Loa Loa (eye worm)	neuropeptide F receptor	0.0176	0	0.5
Loa Loa (eye worm)	hypothetical protein	0.0176	0	0.5
Onchocerca volvulus		0.0176	0	0.5
Echinococcus granulosus	g-protein coupled receptor	0.0176	0	0.5
Schistosoma mansoni	growth hormone secretagogue receptor	0.0176	0	0.5
Brugia malayi	G protein-coupled receptor	0.0176	0	0.5
Echinococcus granulosus	neuropeptide Y receptor	0.0176	0	0.5
Echinococcus multilocularis	G protein coupled receptor 139	0.0176	0	0.5
Loa Loa (eye worm)	hypothetical protein	0.0176	0	0.5
Echinococcus multilocularis	neuropeptides capa receptor	0.0176	0	0.5
Echinococcus multilocularis	G protein coupled 5 hydroxytryptamine receptor	0.0176	0	0.5
Onchocerca volvulus		0.0176	0	0.5
Brugia malayi	hypothetical protein	0.0176	0	0.5
Echinococcus granulosus	rhodopsin orphan GPCR	0.0176	0	0.5
Brugia malayi	G-protein-linked acetylcholine receptor protein 2, putative	0.0176	0	0.5
Echinococcus granulosus	rhodopsin orphan GPCR	0.0176	0	0.5
Echinococcus granulosus	neuropeptide receptor	0.0176	0	0.5
Loa Loa (eye worm)	hypothetical protein	0.0176	0	0.5
Echinococcus granulosus	tm gpcr rhodopsin	0.0176	0	0.5
Echinococcus granulosus	g protein coupled receptor	0.0176	0	0.5
Wolbachia endosymbiont of Brugia malayi	peptide deformylase	0.0279	1	0.5
Onchocerca volvulus	Neuropeptide F receptor homolog	0.0176	0	0.5
Loa Loa (eye worm)	hypothetical protein	0.0176	0	0.5
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0176	0	0.5
Loa Loa (eye worm)	hypothetical protein	0.0176	0	0.5
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0176	0	0.5
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0176	0	0.5
Echinococcus multilocularis	neuropeptide Y receptor	0.0176	0	0.5

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (binding)	= 6 nM	Inhibitory activity against Escherichia coli peptide deformylase (PDF) Nickel containing enzyme	ChEMBL.	14684298
IC50 (binding)	= 6 nM	Inhibitory activity against Escherichia coli peptide deformylase (PDF) Nickel containing enzyme	ChEMBL.	14684298
MIC (functional)	= 0.125 ug ml-1	Minimum inhibitory concentration required for primary screening against in-house strain of Moraxella catarrhalis tested in vitro	ChEMBL.	14684298
MIC (functional)	< 0.5 ug ml-1	Minimum inhibitory concentration required for primary screening against in-house strain of Streptococcus pneumoniae tested in vitro; Range- 0.25-0.5	ChEMBL.	14684298
MIC (functional)	< 4 ug ml-1	Minimum inhibitory concentration required for primary screening against in-house strain of Haemophilus influenzae tested in vitro; Range- 0.125-4	ChEMBL.	14684298

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL350211

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 268786