Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | TK/ROR protein kinase | 0.0768 | 1 | 1 |
Brugia malayi | Kringle domain containing protein | 0.0768 | 1 | 1 |
Leishmania major | hypothetical protein, conserved | 0.0768 | 1 | 0.5 |
Toxoplasma gondii | kringle domain-containing protein | 0.0768 | 1 | 1 |
Onchocerca volvulus | 0.0768 | 1 | 1 | |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0768 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0768 | 1 | 1 |
Echinococcus granulosus | tissue type plasminogen activator | 0.0768 | 1 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0768 | 1 | 1 |
Plasmodium vivax | cysteine repeat modular protein 1, putative | 0.0768 | 1 | 0.5 |
Plasmodium falciparum | cysteine repeat modular protein 1 | 0.0768 | 1 | 0.5 |
Echinococcus multilocularis | tissue type plasminogen activator | 0.0768 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Ratio (functional) | = 7.7 | Inhibition ratio against A-549 cancer cell growth at a concentration of 10e-7 mol/L | ChEMBL. | 14741255 |
Ratio (functional) | = 12.4 | Inhibition ratio against A-549 cancer cell growth at a concentration of 10e-6 mol/L | ChEMBL. | 14741255 |
Ratio (functional) | = 13.2 | Inhibition ratio against A-549 cancer cell growth at a concentration of 10e-8 mol/L | ChEMBL. | 14741255 |
Ratio (functional) | = 22.1 | Inhibition ratio against P-388 cancer cell growth at a concentration of 10e-7 mol/L | ChEMBL. | 14741255 |
Ratio (functional) | = 23.9 | Inhibition ratio against P-388 cancer cell growth at a concentration of 10e-6 mol/L | ChEMBL. | 14741255 |
Ratio (functional) | = 30.7 | Inhibition ratio against P-388 cancer cell growth at a concentration of 10e-8 mol/L | ChEMBL. | 14741255 |
Ratio (functional) | = 55.8 | Inhibition ratio against P-388 cancer cell growth at a concentration of 10e-5 mol/L | ChEMBL. | 14741255 |
Ratio (functional) | = 89.8 | Inhibition ratio against P-388 cancer cell growth at a concentration of 10e-4 mol/L | ChEMBL. | 14741255 |
Ratio (functional) | = 91.8 | Inhibition ratio against A-549 cancer cell growth at a concentration of 10e-5 mol/L | ChEMBL. | 14741255 |
Ratio (functional) | = 96 | Inhibition ratio against A-549 cancer cell growth at a concentration of 10e-4 mol/L | ChEMBL. | 14741255 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.