Detailed information for compound 268911

Basic information

Technical information
  • TDR Targets ID: 268911
  • Name: [6-(2-methylimidazol-1-yl)pyridazin-3-yl]hydr azine
  • MW: 190.205 | Formula: C8H10N6
  • H donors: 2 H acceptors: 3 LogP: -0.1 Rotable bonds: 2
    Rule of 5 violations (Lipinski): 1
  • SMILES: Cc1nccn1c1ccc(nn1)NN
  • InChi: 1S/C8H10N6/c1-6-10-4-5-14(6)8-3-2-7(11-9)12-13-8/h2-5H,9H2,1H3,(H,11,12)
  • InChiKey: SKGCBNQMSDOUPL-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • [6-(2-methyl-1-imidazolyl)-3-pyridazinyl]hydrazine
  • 75792-67-5
  • 3(2H)-Pyridazinone, 6-(2-methyl-1H-imidazol-1-yl)-, hydrazone
  • 3-Hydrazino-6-(2-methylimidazol-1-yl)pyridazine
  • 6-(2-Methyl-1H-imidazol-1-yl)-3(2H)-pyridazinone hydrazone

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trypanosoma brucei Polypeptide deformylase 1 0.0373 0.2289 0.5
Toxoplasma gondii hypothetical protein 0.0977 1 1
Trypanosoma cruzi Peptide deformylase 2, putative 0.0373 0.2289 0.5
Wolbachia endosymbiont of Brugia malayi peptide deformylase 0.0977 1 0.5
Brugia malayi Matrixin family protein 0.0197 0.0046 0.0081
Mycobacterium leprae PROBABLE POLYPEPTIDE DEFORMYLASE DEF (PDF) (FORMYLMETHIONINE DEFORMYLASE) 0.0977 1 1
Loa Loa (eye worm) angiotensin-converting enzyme family protein 0.0643 0.5735 1
Mycobacterium tuberculosis Probable peptidoglycan hydrolase 0.024 0.0594 0.0551
Onchocerca volvulus Matrix metalloproteinase homolog 0.0437 0.311 1
Loa Loa (eye worm) hypothetical protein 0.024 0.0594 0.0964
Loa Loa (eye worm) hypothetical protein 0.0197 0.0046 0.0000068635
Trypanosoma cruzi polypeptide deformylase-like protein, putative 0.0373 0.2289 0.5
Mycobacterium ulcerans hydrolase 0.024 0.0594 0.0551
Echinococcus granulosus matrix metallopeptidase 7 M10 family 0.0631 0.5579 1
Brugia malayi Hypothetical zinc metalloproteinase T16A9.4 0.0197 0.0046 0.0081
Plasmodium vivax peptide deformylase, putative 0.0977 1 0.5
Echinococcus multilocularis matrix metallopeptidase 7 (M10 family) 0.0631 0.5579 1
Onchocerca volvulus 0.0197 0.0046 0.0149
Loa Loa (eye worm) matrixin family protein 0.0437 0.311 0.5386
Leishmania major polypeptide deformylase-like protein, putative 0.0373 0.2289 0.5
Trypanosoma brucei Peptide deformylase 2 0.0373 0.2289 0.5
Brugia malayi Angiotensin-converting enzyme family protein 0.0643 0.5735 1
Mycobacterium leprae PROBABLE HYDROLASE 0.024 0.0594 0.0551
Brugia malayi Matrix metalloprotease, N-terminal domain containing protein 0.024 0.0594 0.1037
Mycobacterium ulcerans peptide deformylase 0.0977 1 1
Onchocerca volvulus Matrilysin homolog 0.0437 0.311 1
Loa Loa (eye worm) matrixin family protein 0.0391 0.2515 0.4341
Brugia malayi Matrixin family protein 0.0197 0.0046 0.0081
Treponema pallidum polypeptide deformylase (def) 0.0977 1 0.5
Schistosoma mansoni matrix metallopeptidase-7 (M10 family) 0.0197 0.0046 0.9992
Brugia malayi Matrixin family protein 0.0197 0.0046 0.0081
Brugia malayi Matrixin family protein 0.0391 0.2515 0.4386
Brugia malayi Peptidase family M13 containing protein 0.0197 0.0046 0.0081
Loa Loa (eye worm) hypothetical protein 0.0197 0.0046 0.0000068635
Mycobacterium tuberculosis Probable polypeptide deformylase Def (PDF) (formylmethionine deformylase) 0.0977 1 1
Onchocerca volvulus Matrilysin homolog 0.0197 0.0046 0.0149
Trypanosoma cruzi polypeptide deformylase-like protein, putative 0.0373 0.2289 0.5
Brugia malayi Matrixin family protein 0.0197 0.0046 0.0081
Schistosoma mansoni family M13 unassigned peptidase (M13 family) 0.0197 0.0046 1
Loa Loa (eye worm) hypothetical protein 0.0197 0.0046 0.0000068635
Plasmodium falciparum peptide deformylase 0.0977 1 0.5
Trypanosoma cruzi Peptide deformylase 2, putative 0.0373 0.2289 0.5

Activities

Activity type Activity value Assay description Source Reference
ED20 (functional) = 0.163 uM kg-1 Hypotensive activity was measured as ED20 which is the dose lowered the normal arterial pressure in anesthetized rats by 20% aftter iv administration ChEMBL. 7205877
ED20 (functional) = 7.42 uM kg-1 Antihypertensive activity was measured as ED20 which is the dose lowered the normal arterial pressure in conscious SH rats by 20% after po administration ChEMBL. 7205877
LD50 (ADMET) = 1016 uM kg-1 Acute toxicity was measured as LD50 in mice after ip administration ChEMBL. 7205877
LD50 (ADMET) = 1016 uM kg-1 Acute toxicity was measured as LD50 in mice after ip administration ChEMBL. 7205877
Relative potency (functional) = 2.75 Relative potency of compound was measured in anesthetized rats aftter ip administration ChEMBL. 7205877
Relative potency (functional) = 4.88 Relative potency of compound was measured in conscious SH rats after po administration ChEMBL. 7205877

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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