Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Rattus norvegicus | Vanilloid receptor | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | transient receptor potential cation channel | 0.0004 | 0.0062 | 0.0062 |
Toxoplasma gondii | eukaryotic initiation factor-4A, putative | 0.0052 | 1 | 0.5 |
Echinococcus granulosus | eukaryotic initiation factor 4A III | 0.0052 | 1 | 1 |
Trichomonas vaginalis | DEAD box ATP-dependent RNA helicase, putative | 0.0052 | 1 | 0.5 |
Treponema pallidum | ATP-dependent RNA helicase | 0.0052 | 1 | 0.5 |
Giardia lamblia | Translation initiation factor eIF-4A, putative | 0.0052 | 1 | 0.5 |
Trypanosoma cruzi | Eukaryotic initiation factor 4A-1 | 0.0052 | 1 | 0.5 |
Trypanosoma brucei | Eukaryotic initiation factor 4A-1 | 0.0052 | 1 | 0.5 |
Schistosoma mansoni | transient receptor potential channel | 0.0004 | 0.0062 | 0.0062 |
Leishmania major | eukaryotic initiation factor 4a, putative | 0.0052 | 1 | 0.5 |
Trichomonas vaginalis | DEAD box ATP-dependent RNA helicase, putative | 0.0052 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0052 | 1 | 1 |
Echinococcus granulosus | short transient receptor potential channel 6 | 0.0004 | 0.0062 | 0.0062 |
Echinococcus granulosus | eukaryotic initiation factor 4A | 0.0052 | 1 | 1 |
Echinococcus multilocularis | short transient receptor potential channel 6 | 0.0004 | 0.0062 | 0.0062 |
Leishmania major | eukaryotic initiation factor 4a, putative | 0.0052 | 1 | 0.5 |
Schistosoma mansoni | DEAD box ATP-dependent RNA helicase | 0.0052 | 1 | 1 |
Echinococcus multilocularis | eukaryotic initiation factor 4A III | 0.0052 | 1 | 1 |
Trypanosoma cruzi | Eukaryotic initiation factor 4A-1 | 0.0052 | 1 | 0.5 |
Entamoeba histolytica | DEAD/DEAH box helicase, putative | 0.0052 | 1 | 0.5 |
Mycobacterium tuberculosis | Probable cold-shock DeaD-box protein A homolog DeaD (ATP-dependent RNA helicase dead homolog) | 0.0052 | 1 | 0.5 |
Trichomonas vaginalis | DEAD box ATP-dependent RNA helicase, putative | 0.0052 | 1 | 0.5 |
Echinococcus multilocularis | transient receptor potential cation channel | 0.0004 | 0.0062 | 0.0062 |
Echinococcus multilocularis | transient receptor potential cation channel | 0.0004 | 0.0062 | 0.0062 |
Onchocerca volvulus | Eukaryotic initiation factor 4A homolog | 0.0052 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0004 | 0.0062 | 0.0062 |
Plasmodium vivax | RNA helicase-1, putative | 0.0052 | 1 | 0.5 |
Schistosoma mansoni | DEAD box ATP-dependent RNA helicase | 0.0052 | 1 | 1 |
Plasmodium falciparum | eukaryotic initiation factor 4A | 0.0052 | 1 | 0.5 |
Echinococcus multilocularis | eukaryotic initiation factor 4A | 0.0052 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
EC50 (functional) | 0 uM | Agonist activity towards vanilloid receptor was tested in [Ca2+] influx assay by using neonatal rat culture spinal sensory neurons (NE=Not effective at 30 uM) | ChEMBL. | 12639539 |
IC50 (functional) | = 6.1 nM | Antagonistic activity against vanilloid receptor as concentration to reduce the response to 0.5 mM capsaicin by 50% from neonatal rat culture spinal sensory neurons using [Ca2+] -influx assay | ChEMBL. | 12639539 |
IC50 (functional) | = 6.1 nM | Antagonistic activity against vanilloid receptor as concentration to reduce the response to 0.5 mM capsaicin by 50% from neonatal rat culture spinal sensory neurons using [Ca2+] -influx assay | ChEMBL. | 12639539 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.