Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase) | Starlite/ChEMBL | References |
Homo sapiens | prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Onchocerca volvulus | 0.0211 | 0.5 | 0.5 | |
Echinococcus granulosus | enteropeptidase | 0.0211 | 0.5 | 0.5 |
Brugia malayi | Trypsin family protein | 0.0211 | 0.5 | 0.5 |
Schistosoma mansoni | cercarial elastase (S01 family) | 0.0211 | 0.5 | 0.5 |
Echinococcus multilocularis | enteropeptidase | 0.0211 | 0.5 | 0.5 |
Echinococcus multilocularis | Peptidase S1 S6, chymotrypsin Hap | 0.0211 | 0.5 | 0.5 |
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | 0.0211 | 0.5 | 0.5 |
Schistosoma mansoni | cercarial elastase (S01 family) | 0.0211 | 0.5 | 0.5 |
Schistosoma mansoni | cercarial elastase (S01 family) | 0.0211 | 0.5 | 0.5 |
Brugia malayi | Trypsin family protein | 0.0211 | 0.5 | 0.5 |
Schistosoma mansoni | cercarial elastase (S01 family) | 0.0211 | 0.5 | 0.5 |
Loa Loa (eye worm) | trypsin family protein | 0.0211 | 0.5 | 0.5 |
Echinococcus multilocularis | Mastin | 0.0211 | 0.5 | 0.5 |
Onchocerca volvulus | 0.0211 | 0.5 | 0.5 | |
Onchocerca volvulus | 0.0211 | 0.5 | 0.5 | |
Schistosoma mansoni | cercarial elastase (S01 family) | 0.0211 | 0.5 | 0.5 |
Echinococcus multilocularis | transmembrane protease serine 3 | 0.0211 | 0.5 | 0.5 |
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | 0.0211 | 0.5 | 0.5 |
Echinococcus granulosus | glycoprotein Antigen 5 | 0.0211 | 0.5 | 0.5 |
Echinococcus multilocularis | glycoprotein Antigen 5 | 0.0211 | 0.5 | 0.5 |
Onchocerca volvulus | 0.0211 | 0.5 | 0.5 | |
Loa Loa (eye worm) | hypothetical protein | 0.0211 | 0.5 | 0.5 |
Brugia malayi | Trypsin family protein | 0.0211 | 0.5 | 0.5 |
Brugia malayi | hypothetical protein | 0.0211 | 0.5 | 0.5 |
Onchocerca volvulus | 0.0211 | 0.5 | 0.5 | |
Echinococcus granulosus | transmembrane protease serine 3 | 0.0211 | 0.5 | 0.5 |
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | 0.0211 | 0.5 | 0.5 |
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | 0.0211 | 0.5 | 0.5 |
Brugia malayi | Chymotrypsin-like protease CTRL-1 precursor | 0.0211 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0211 | 0.5 | 0.5 |
Brugia malayi | Trypsin-like protease protein 5 | 0.0211 | 0.5 | 0.5 |
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | 0.0211 | 0.5 | 0.5 |
Mycobacterium ulcerans | hypothetical protein | 0.0211 | 0.5 | 0.5 |
Schistosoma mansoni | cercarial elastase (S01 family) | 0.0211 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0211 | 0.5 | 0.5 |
Echinococcus granulosus | Mastin | 0.0211 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0211 | 0.5 | 0.5 |
Schistosoma mansoni | cercarial elastase (S01 family) | 0.0211 | 0.5 | 0.5 |
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | 0.0211 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0211 | 0.5 | 0.5 |
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | 0.0211 | 0.5 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0211 | 0.5 | 0.5 |
Schistosoma mansoni | cercarial elastase (S01 family) | 0.0211 | 0.5 | 0.5 |
Echinococcus granulosus | Peptidase S1 S6 chymotrypsin Hap | 0.0211 | 0.5 | 0.5 |
Echinococcus multilocularis | subfamily S1A unassigned peptidase (S01 family) | 0.0211 | 0.5 | 0.5 |
Onchocerca volvulus | 0.0211 | 0.5 | 0.5 | |
Schistosoma mansoni | hypothetical protein | 0.0211 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0211 | 0.5 | 0.5 |
Echinococcus granulosus | subfamily S1A unassigned peptidase S01 family | 0.0211 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0211 | 0.5 | 0.5 |
Schistosoma mansoni | cercarial elastase (S01 family) | 0.0211 | 0.5 | 0.5 |
Schistosoma mansoni | cercarial elastase (S01 family) | 0.0211 | 0.5 | 0.5 |
Schistosoma mansoni | aminopeptidase PILS (M01 family) | 0.0211 | 0.5 | 0.5 |
Schistosoma mansoni | cercarial elastase (S01 family) | 0.0211 | 0.5 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 0.33 uM | Inhibitory activity against human prostaglandin G/H synthase 2 in ECV-304 cells measured by the presence of PGE-2 | ChEMBL. | 10741562 |
IC50 (binding) | = 0.33 uM | Inhibitory activity against human prostaglandin G/H synthase 2 in ECV-304 cells measured by the presence of PGE-2 | ChEMBL. | 10741562 |
IC50 (binding) | > 10 uM | Inhibitory activity against human prostaglandin G/H synthase 1 in platelet-rich plasma measured by the presence of thromboxane A2 | ChEMBL. | 10741562 |
IC50 (binding) | > 10 uM | Inhibitory activity against human prostaglandin G/H synthase 1 in platelet-rich plasma measured by the presence of thromboxane A2 | ChEMBL. | 10741562 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.