Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Schistosoma mansoni | integrin beta subunit | Get druggable targets OG5_127959 | All targets in OG5_127959 |
Loa Loa (eye worm) | integrin beta-2 | Get druggable targets OG5_127959 | All targets in OG5_127959 |
Echinococcus granulosus | integrin beta 2 | Get druggable targets OG5_127959 | All targets in OG5_127959 |
Schistosoma japonicum | Integrin beta-PS precursor, putative | Get druggable targets OG5_127959 | All targets in OG5_127959 |
Brugia malayi | Integrin beta pat-3 precursor | Get druggable targets OG5_127959 | All targets in OG5_127959 |
Echinococcus multilocularis | integrin beta 2 | Get druggable targets OG5_127959 | All targets in OG5_127959 |
Schistosoma japonicum | ko:K06464 integrin beta 2, putative | Get druggable targets OG5_127959 | All targets in OG5_127959 |
Schistosoma japonicum | Integrin beta-3 precursor, putative | Get druggable targets OG5_127959 | All targets in OG5_127959 |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | tyrosine kinase | 0.0169 | 0.2212 | 0.2212 |
Echinococcus multilocularis | insulin receptor | 0.0169 | 0.2212 | 0.2212 |
Mycobacterium ulcerans | hypothetical protein | 0.0078 | 0.0341 | 0.0468 |
Leishmania major | uracil-DNA-glycosylase, putative | 0.0149 | 0.1801 | 1 |
Echinococcus granulosus | integrin beta 2 | 0.028 | 0.4504 | 0.4504 |
Mycobacterium leprae | PROBABLE DNA POLYMERASE III (ALPHA CHAIN) DNAE1 (DNA NUCLEOTIDYLTRANSFERASE) | 0.0417 | 0.7327 | 1 |
Schistosoma mansoni | tyrosine kinase | 0.0404 | 0.7058 | 0.7058 |
Brugia malayi | Protein kinase domain containing protein | 0.0169 | 0.2212 | 0.0502 |
Trypanosoma cruzi | uracil-DNA glycosylase | 0.0149 | 0.1801 | 0.5 |
Loa Loa (eye worm) | TK/INSR protein kinase | 0.0169 | 0.2212 | 0.0502 |
Schistosoma mansoni | G/t mismatch-specific thymine DNA glycosylase | 0.0064 | 0.0036 | 0.0036 |
Wolbachia endosymbiont of Brugia malayi | DNA polymerase III alpha subunit | 0.0415 | 0.7284 | 1 |
Mycobacterium tuberculosis | Conserved hypothetical protein | 0.0078 | 0.0341 | 0.0466 |
Echinococcus granulosus | melanoma receptor tyrosine protein kinase | 0.0404 | 0.7058 | 0.7058 |
Schistosoma mansoni | tyrosine kinase | 0.0402 | 0.7022 | 0.7022 |
Echinococcus multilocularis | uracil DNA glycosylase | 0.0149 | 0.1801 | 0.1801 |
Schistosoma mansoni | tyrosine kinase | 0.0169 | 0.2212 | 0.2212 |
Mycobacterium tuberculosis | Probable uracil DNA glycosylase, UdgB | 0.0064 | 0.0036 | 0.005 |
Brugia malayi | Integrin beta pat-3 precursor | 0.0378 | 0.6527 | 0.5765 |
Loa Loa (eye worm) | TK/EGFR protein kinase | 0.0546 | 1 | 1 |
Mycobacterium tuberculosis | Probable DNA polymerase III (alpha chain) DnaE2 (DNA nucleotidyltransferase) | 0.0417 | 0.7327 | 1 |
Mycobacterium ulcerans | glycosylase | 0.0064 | 0.0036 | 0.005 |
Schistosoma mansoni | tyrosine kinase | 0.0546 | 1 | 1 |
Mycobacterium ulcerans | uracil-DNA glycosylase | 0.0149 | 0.1801 | 0.2472 |
Echinococcus granulosus | epidermal growth factor receptor | 0.0404 | 0.7058 | 0.7058 |
Plasmodium falciparum | uracil-DNA glycosylase | 0.0149 | 0.1801 | 0.5 |
Echinococcus multilocularis | integrin beta 2 | 0.028 | 0.4504 | 0.4504 |
Chlamydia trachomatis | DNA polymerase III subunit alpha | 0.0415 | 0.7284 | 1 |
Loa Loa (eye worm) | integrin beta-2 | 0.0378 | 0.6527 | 0.5765 |
Mycobacterium ulcerans | hypothetical protein | 0.0064 | 0.0036 | 0.005 |
Entamoeba histolytica | uracil-DNA glycosylase, putative | 0.0149 | 0.1801 | 1 |
Echinococcus multilocularis | insulin growth factor 1 receptor beta | 0.0169 | 0.2212 | 0.2212 |
Echinococcus multilocularis | epidermal growth factor receptor | 0.0404 | 0.7058 | 0.7058 |
Echinococcus granulosus | tumor protein p63 | 0.0345 | 0.5836 | 0.5836 |
Mycobacterium leprae | PROBABLE URACIL-DNA GLYCOSYLASE UNG (UDG) | 0.0149 | 0.1801 | 0.242 |
Schistosoma mansoni | tyrosine kinase | 0.0402 | 0.7022 | 0.7022 |
Toxoplasma gondii | uracil-DNA glycosylase | 0.0149 | 0.1801 | 1 |
Echinococcus granulosus | insulin receptor | 0.0169 | 0.2212 | 0.2212 |
Plasmodium vivax | uracil-DNA glycosylase, putative | 0.0149 | 0.1801 | 0.5 |
Schistosoma mansoni | tyrosine kinase | 0.0404 | 0.7058 | 0.7058 |
Echinococcus granulosus | uracil DNA glycosylase | 0.0149 | 0.1801 | 0.1801 |
Mycobacterium ulcerans | DNA polymerase III subunit alpha | 0.0415 | 0.7284 | 1 |
Trypanosoma brucei | uracil-DNA glycosylase, putative | 0.0149 | 0.1801 | 0.5 |
Mycobacterium tuberculosis | Probable uracil-DNA glycosylase Ung (UDG) | 0.0085 | 0.0486 | 0.0663 |
Trichomonas vaginalis | uracil DNA glycosylase, putative | 0.0149 | 0.1801 | 0.5 |
Mycobacterium tuberculosis | Probable DNA polymerase III (alpha chain) DnaE1 (DNA nucleotidyltransferase) | 0.0417 | 0.7327 | 1 |
Schistosoma mansoni | uracil-DNA glycosylase | 0.0149 | 0.1801 | 0.1801 |
Echinococcus granulosus | insulin growth factor 1 receptor beta | 0.0169 | 0.2212 | 0.2212 |
Echinococcus multilocularis | 0.0334 | 0.561 | 0.561 | |
Schistosoma mansoni | integrin beta subunit | 0.0223 | 0.3318 | 0.3318 |
Echinococcus multilocularis | tumor protein p63 | 0.0345 | 0.5836 | 0.5836 |
Echinococcus granulosus | epidermal growth factor receptor | 0.0546 | 1 | 1 |
Mycobacterium ulcerans | error-prone DNA polymerase | 0.0415 | 0.7284 | 1 |
Echinococcus multilocularis | epidermal growth factor receptor | 0.0546 | 1 | 1 |
Schistosoma mansoni | tyrosine kinase | 0.0402 | 0.7022 | 0.7022 |
Treponema pallidum | DNA polymerase III subunit alpha | 0.0415 | 0.7284 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 2.1 nM | Inhibitory activity against alpha4 beta1 receptor (VLA-4) in human RPMI-8866 cells using [125I]-VCAM-Ig ligand | ChEMBL. | 11844683 |
IC50 (binding) | = 2.1 nM | Inhibitory activity against alpha4 beta1 receptor (VLA-4) in human RPMI-8866 cells using [125I]-VCAM-Ig ligand | ChEMBL. | 11844683 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.