Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trichomonas vaginalis | conserved hypothetical protein | 0.1572 | 0 | 0.5 |
Mycobacterium leprae | CARBONIC ANHYDRASE (CARBONATE DEHYDRATASE) (CARBONIC DEHYDRATASE) | 0.1634 | 0.7846 | 0.5 |
Leishmania major | carbonic anhydrase-like protein | 0.1651 | 1 | 1 |
Trypanosoma cruzi | carbonic anhydrase-like protein, putative | 0.1651 | 1 | 0.5 |
Trichomonas vaginalis | conserved hypothetical protein | 0.1572 | 0 | 0.5 |
Echinococcus granulosus | carbonic anhydrase II | 0.1651 | 1 | 0.5 |
Schistosoma mansoni | carbonic anhydrase II (carbonate dehydratase II) | 0.1651 | 1 | 1 |
Brugia malayi | Putative carbonic anhydrase 5 precursor | 0.1651 | 1 | 0.5 |
Loa Loa (eye worm) | eukaryotic-type carbonic anhydrase | 0.1651 | 1 | 0.5 |
Loa Loa (eye worm) | carbonic anhydrase 3 | 0.1651 | 1 | 0.5 |
Trypanosoma brucei | carbonic anhydrase-like protein | 0.1651 | 1 | 0.5 |
Mycobacterium ulcerans | carbonic anhydrase | 0.1634 | 0.7846 | 1 |
Trypanosoma cruzi | carbonic anhydrase-like protein, putative | 0.1651 | 1 | 0.5 |
Entamoeba histolytica | carbonic anhydrase, putative | 0.1634 | 0.7846 | 0.5 |
Echinococcus multilocularis | carbonic anhydrase II | 0.1651 | 1 | 0.5 |
Schistosoma mansoni | carbonic anhydrase II (carbonate dehydratase II) | 0.1651 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (functional) | NA 0 | Activity in the spontaneously hypertensive rats (SHR); inactive = post treatment BP did not change | ChEMBL. | 1967650 |
Activity (functional) | 0 | Inhibition of increase in potential difference caused by diarrhea inducing secretogogues determined in rabbit; + = moderate activity | ChEMBL. | 1967650 |
ID50 (functional) | = 6.9 mg kg-1 | Antisecretory activity determined after (sc) administration in rat using rat cholera toxin secretion assay | ChEMBL. | 1967650 |
logP (ADMET) | = 2.89 | Partition coefficient (logP) | ChEMBL. | 1967650 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.