Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | aminopeptidase PILS (M01 family) | 0.0224 | 0.6756 | 0.6756 |
Echinococcus multilocularis | enteropeptidase | 0.0224 | 0.6756 | 1 |
Brugia malayi | hypothetical protein | 0.0224 | 0.6756 | 0.6756 |
Leishmania major | tyrosyl-DNA phosphodiesterase 1 | 0.0072 | 0.1176 | 1 |
Schistosoma mansoni | cercarial elastase (S01 family) | 0.0224 | 0.6756 | 0.6756 |
Schistosoma mansoni | tyrosyl-DNA phosphodiesterase | 0.0072 | 0.1176 | 0.1176 |
Schistosoma mansoni | hypothetical protein | 0.0224 | 0.6756 | 0.6756 |
Loa Loa (eye worm) | hypothetical protein | 0.0224 | 0.6756 | 0.6756 |
Schistosoma mansoni | cercarial elastase (S01 family) | 0.0224 | 0.6756 | 0.6756 |
Onchocerca volvulus | 0.0258 | 0.8002 | 0.8002 | |
Trypanosoma brucei | tyrosyl-DNA Phosphodiesterase (Tdp1), putative | 0.0072 | 0.1176 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0312 | 1 | 1 |
Onchocerca volvulus | 0.0224 | 0.6756 | 0.6756 | |
Plasmodium vivax | cysteine repeat modular protein 1, putative | 0.004 | 0 | 0.5 |
Mycobacterium tuberculosis | Probable short-chain type dehydrogenase/reductase | 0.0062 | 0.0831 | 0.5 |
Brugia malayi | Trypsin family protein | 0.0224 | 0.6756 | 0.6756 |
Schistosoma mansoni | cercarial elastase (S01 family) | 0.0224 | 0.6756 | 0.6756 |
Loa Loa (eye worm) | hypothetical protein | 0.0224 | 0.6756 | 0.6756 |
Trypanosoma cruzi | tyrosyl-DNA Phosphodiesterase (Tdp1), putative | 0.0072 | 0.1176 | 1 |
Echinococcus granulosus | transcription factor Dp 1 | 0.0042 | 0.0066 | 0.0097 |
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | 0.0224 | 0.6756 | 0.6756 |
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | 0.0224 | 0.6756 | 0.6756 |
Toxoplasma gondii | kringle domain-containing protein | 0.004 | 0 | 0.5 |
Loa Loa (eye worm) | 3-hydroxyacyl-CoA dehydrogenase type II | 0.0058 | 0.0676 | 0.0676 |
Trypanosoma cruzi | tyrosyl-DNA Phosphodiesterase (Tdp1), putative | 0.0072 | 0.1176 | 1 |
Echinococcus granulosus | Peptidase S1 S6 chymotrypsin Hap | 0.0224 | 0.6756 | 1 |
Onchocerca volvulus | 0.0088 | 0.1784 | 0.1784 | |
Onchocerca volvulus | 0.0224 | 0.6756 | 0.6756 | |
Mycobacterium ulcerans | hypothetical protein | 0.0224 | 0.6756 | 1 |
Echinococcus granulosus | 3 hydroxyacyl coenzyme A dehydrogenase type 2 | 0.0062 | 0.0831 | 0.1229 |
Loa Loa (eye worm) | hypothetical protein | 0.0224 | 0.6756 | 0.6756 |
Loa Loa (eye worm) | tyrosyl-DNA phosphodiesterase | 0.0072 | 0.1176 | 0.1176 |
Schistosoma mansoni | cercarial elastase (S01 family) | 0.0224 | 0.6756 | 0.6756 |
Brugia malayi | 3-hydroxyacyl-CoA dehydrogenase type II | 0.0062 | 0.0831 | 0.0831 |
Loa Loa (eye worm) | pre-SET domain-containing protein family protein | 0.0226 | 0.6849 | 0.6849 |
Schistosoma mansoni | cercarial elastase (S01 family) | 0.0224 | 0.6756 | 0.6756 |
Loa Loa (eye worm) | hypothetical protein | 0.0224 | 0.6756 | 0.6756 |
Loa Loa (eye worm) | hypothetical protein | 0.0224 | 0.6756 | 0.6756 |
Echinococcus granulosus | subfamily S1A unassigned peptidase S01 family | 0.0224 | 0.6756 | 1 |
Onchocerca volvulus | 0.0224 | 0.6756 | 0.6756 | |
Onchocerca volvulus | 0.0224 | 0.6756 | 0.6756 | |
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | 0.0312 | 1 | 1 |
Echinococcus granulosus | tyrosyl DNA phosphodiesterase 1 | 0.0072 | 0.1176 | 0.174 |
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | 0.0224 | 0.6756 | 0.6756 |
Brugia malayi | Pre-SET motif family protein | 0.0226 | 0.6849 | 0.6849 |
Schistosoma mansoni | hypothetical protein | 0.0224 | 0.6756 | 0.6756 |
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | 0.0224 | 0.6756 | 0.6756 |
Echinococcus granulosus | transmembrane protease serine 3 | 0.0224 | 0.6756 | 1 |
Brugia malayi | Trypsin family protein | 0.0224 | 0.6756 | 0.6756 |
Echinococcus multilocularis | 3 hydroxyacyl coenzyme A dehydrogenase type 2 | 0.0062 | 0.0831 | 0.1229 |
Brugia malayi | Trypsin family protein | 0.0224 | 0.6756 | 0.6756 |
Echinococcus granulosus | nuclear factor of activated T cells 5 | 0.008 | 0.148 | 0.2191 |
Schistosoma mansoni | cercarial elastase (S01 family) | 0.0224 | 0.6756 | 0.6756 |
Schistosoma mansoni | 3-hydroxyacyl-CoA dehydrogenase | 0.0062 | 0.0831 | 0.0831 |
Trichomonas vaginalis | set domain proteins, putative | 0.0257 | 0.7997 | 0.5 |
Echinococcus multilocularis | glycoprotein Antigen 5 | 0.0224 | 0.6756 | 1 |
Echinococcus multilocularis | tyrosyl DNA phosphodiesterase 1 | 0.0072 | 0.1176 | 0.174 |
Entamoeba histolytica | tyrosyl-DNA phosphodiesterase, putative | 0.0072 | 0.1176 | 0.5 |
Plasmodium falciparum | cysteine repeat modular protein 1 | 0.004 | 0 | 0.5 |
Echinococcus multilocularis | Mastin | 0.0224 | 0.6756 | 1 |
Echinococcus granulosus | glycoprotein Antigen 5 | 0.0224 | 0.6756 | 1 |
Echinococcus multilocularis | transcription factor Dp 1 | 0.0042 | 0.0066 | 0.0097 |
Echinococcus granulosus | Mastin | 0.0224 | 0.6756 | 1 |
Schistosoma mansoni | cercarial elastase (S01 family) | 0.0224 | 0.6756 | 0.6756 |
Echinococcus multilocularis | Peptidase S1 S6, chymotrypsin Hap | 0.0224 | 0.6756 | 1 |
Brugia malayi | Trypsin-like protease protein 5 | 0.0224 | 0.6756 | 0.6756 |
Echinococcus granulosus | enteropeptidase | 0.0224 | 0.6756 | 1 |
Schistosoma mansoni | cercarial elastase (S01 family) | 0.0224 | 0.6756 | 0.6756 |
Brugia malayi | Chymotrypsin-like protease CTRL-1 precursor | 0.0224 | 0.6756 | 0.6756 |
Onchocerca volvulus | 0.0224 | 0.6756 | 0.6756 | |
Brugia malayi | Tyrosyl-DNA phosphodiesterase family protein | 0.0072 | 0.1176 | 0.1176 |
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | 0.0224 | 0.6756 | 0.6756 |
Onchocerca volvulus | 0.0312 | 1 | 1 | |
Loa Loa (eye worm) | hypothetical protein | 0.0312 | 1 | 1 |
Schistosoma mansoni | cercarial elastase (S01 family) | 0.0224 | 0.6756 | 0.6756 |
Echinococcus multilocularis | subfamily S1A unassigned peptidase (S01 family) | 0.0224 | 0.6756 | 1 |
Leishmania major | 3-oxoacyl-(acyl-carrier protein) reductase, putative | 0.0062 | 0.0831 | 0.7064 |
Echinococcus multilocularis | transmembrane protease serine 3 | 0.0224 | 0.6756 | 1 |
Schistosoma mansoni | cercarial elastase (S01 family) | 0.0224 | 0.6756 | 0.6756 |
Echinococcus multilocularis | nuclear factor of activated T cells 5 | 0.008 | 0.148 | 0.2191 |
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | 0.0312 | 1 | 1 |
Loa Loa (eye worm) | trypsin family protein | 0.0224 | 0.6756 | 0.6756 |
Schistosoma mansoni | cercarial elastase (S01 family) | 0.0224 | 0.6756 | 0.6756 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
ED50 (functional) | 0 mg kg-1 | Compound was evaluated for maximal electroshock antagonism (MES) against mice; Inactive | ChEMBL. | 6716399 |
HYPO (functional) | = 0 mg kg-1 | Evaluated for antagonism of reserpine induced hypothermia; 0.5-2.5 mg/kg | ChEMBL. | 6716399 |
LD50 (ADMET) | = 200 mg kg-1 | Lethal dose in mouse, in groups of ten | ChEMBL. | 6716399 |
LD50 (ADMET) | = 200 mg kg-1 | Lethal dose in mouse, in groups of ten | ChEMBL. | 6716399 |
Mouse behavior activity (functional) | S-D 0 | Mouse behavior activity was determined; S-D=Stimulant-Depressant | ChEMBL. | 6716399 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.