Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium tuberculosis | Probable protease II PtrBa [first part] (oligopeptidase B) | 0.0434179 | 0.806305 | 1 |
Onchocerca volvulus | Prolyl endopeptidase homolog | 0.050838 | 1 | 1 |
Onchocerca volvulus | 0.0177318 | 0.13579 | 0.0692718 | |
Trypanosoma cruzi | oligopeptidase b | 0.0169784 | 0.116123 | 0.116123 |
Toxoplasma gondii | prolyl endopeptidase | 0.050838 | 1 | 0.5 |
Trypanosoma brucei | prolyl oligopeptidase, putative | 0.0169784 | 0.116123 | 0.116123 |
Trypanosoma cruzi | serine peptidase, clan SC, family S9A-like protein, putative | 0.0169784 | 0.116123 | 0.116123 |
Echinococcus granulosus | prolyl endopeptidase | 0.050838 | 1 | 1 |
Mycobacterium leprae | PROBABLE PROTEASE II PTRBB (OLIGOPEPTIDASE B) | 0.0169784 | 0.116123 | 0.5 |
Loa Loa (eye worm) | gamma-secretase subunit aph-1 | 0.0319586 | 0.507168 | 0.429731 |
Trypanosoma cruzi | oligopeptidase B-like protein, putative | 0.0169784 | 0.116123 | 0.116123 |
Brugia malayi | prolyl oligopeptidase family protein | 0.050838 | 1 | 1 |
Mycobacterium ulcerans | protease II (oligopeptidase B), PtrB | 0.0169784 | 0.116123 | 0.5 |
Trypanosoma cruzi | oligopeptidase b | 0.0169784 | 0.116123 | 0.116123 |
Trypanosoma brucei | serine peptidase, clan SC, family S9A-like protein | 0.0169784 | 0.116123 | 0.116123 |
Brugia malayi | gamma-secretase subunit aph-1 | 0.0319586 | 0.507168 | 0.429731 |
Echinococcus multilocularis | prolyl endopeptidase | 0.050838 | 1 | 1 |
Leishmania major | prolyl oligopeptidase, putative,serine peptidase clan SC, family S9A, putative | 0.050838 | 1 | 1 |
Trypanosoma brucei | oligopeptidase b | 0.0169784 | 0.116123 | 0.116123 |
Schistosoma mansoni | gamma-secretase subunit aph-1 | 0.0319586 | 0.507168 | 0.429731 |
Trypanosoma brucei | prolyl endopeptidase | 0.050838 | 1 | 1 |
Trypanosoma cruzi | prolyl endopeptidase | 0.050838 | 1 | 1 |
Schistosoma mansoni | prolyl oligopeptidase (S09 family) | 0.050838 | 1 | 1 |
Schistosoma mansoni | prolyl oligopeptidase (S09 family) | 0.050838 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.050838 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
EC50 (functional) | uM | Antiparasitic activity against malaria parasite Plasmodium falciparum D6 | ChEMBL. | 14741254 |
EC50 (functional) | NA 0 uM | Antiparasitic activity against malaria parasite Plasmodium falciparum D6 | ChEMBL. | 14741254 |
EC50 (functional) | = 9.34 uM | Antiparasitic activity against chloroquine resistant Plasmodium falciparum W2 strain | ChEMBL. | 14741254 |
EC50 (functional) | = 9.34 uM | Antiparasitic activity against chloroquine resistant Plasmodium falciparum W2 strain | ChEMBL. | 14741254 |
EC50 (functional) | = 10.04 uM | Antiparasitic activity against Leishmania promastigotes (Leishmania donovani) | ChEMBL. | 14741254 |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Plasmodium falciparum | ChEMBL23 | 14741254 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.