Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Leishmania major | C-8 sterol isomerase-like protein | 0.1682 | 1 | 0.5 |
Echinococcus multilocularis | Glutamate receptor, ionotropic kainate 2 | 0.0489 | 0.0327 | 0.1034 |
Loa Loa (eye worm) | hypothetical protein | 0.086 | 0.3334 | 0.3334 |
Schistosoma mansoni | glutamate receptor NMDA | 0.0838 | 0.3158 | 1 |
Echinococcus multilocularis | Glutamate receptor, ionotropic kainate 2 | 0.0489 | 0.0327 | 0.1034 |
Echinococcus multilocularis | Glutamate receptor, ionotropic kainate 2 | 0.0489 | 0.0327 | 0.1034 |
Echinococcus granulosus | glutamate NMDA receptor subunit | 0.0838 | 0.3158 | 1 |
Schistosoma mansoni | glutamate receptor NMDA | 0.0767 | 0.2582 | 0.8177 |
Echinococcus multilocularis | glutamate receptor, ionotrophic, AMPA 3 | 0.0489 | 0.0327 | 0.1034 |
Trypanosoma brucei | C-8 sterol isomerase, putative | 0.1682 | 1 | 0.5 |
Echinococcus multilocularis | glutamate (NMDA) receptor subunit | 0.0838 | 0.3158 | 1 |
Echinococcus multilocularis | glutamate receptor 2 | 0.0489 | 0.0327 | 0.1034 |
Loa Loa (eye worm) | hypothetical protein | 0.1682 | 1 | 1 |
Trypanosoma cruzi | C-8 sterol isomerase, putative | 0.1682 | 1 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | > 100 uM | In vitro inhibitory activity against TNF-alpha production in mouse macrophages stimulated with LPS | ChEMBL. | No reference |
IC50 (functional) | > 100 uM | In vitro inhibitory activity against TNF-alpha production in mouse macrophages stimulated with LPS | ChEMBL. | No reference |
Ki (binding) | uM | Inhibition of [3H]-Spiroperidol binding to dopamine receptor from rat striatum membranes; Inactive | ChEMBL. | 6248642 |
Ki (binding) | uM | Inhibition of [3H]-WB-4101 binding to alpha adrenergic receptor from rat cerebral cortical membranes; Inactive | ChEMBL. | 6248642 |
Ki (binding) | uM | Inhibition of [3H]-Dihydroalprenolol binding to Beta adrenergic receptor from rat cerebral cortical membranes | ChEMBL. | 6248642 |
Ki (binding) | 0 uM | Inhibition of [3H]-Dihydroalprenolol binding to Beta adrenergic receptor from rat cerebral cortical membranes | ChEMBL. | 6248642 |
Ki (binding) | 0 uM | Inhibition of [3H]-Spiroperidol binding to dopamine receptor from rat striatum membranes; Inactive | ChEMBL. | 6248642 |
Ki (binding) | 0 uM | Inhibition of [3H]-WB-4101 binding to alpha adrenergic receptor from rat cerebral cortical membranes; Inactive | ChEMBL. | 6248642 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.