Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | pyruvate dehydrogenase | 0.0629 | 0.7873 | 0.7873 |
Trypanosoma brucei | developmentally regulated phosphoprotein | 0.0666 | 0.8409 | 1 |
Onchocerca volvulus | Dual specificity protein kinase TTK homolog | 0.0085 | 0 | 0.5 |
Leishmania major | developmentally regulated phosphoprotein-like protein | 0.0666 | 0.8409 | 1 |
Trypanosoma cruzi | developmentally regulated phosphoprotein, putative | 0.0666 | 0.8409 | 1 |
Schistosoma mansoni | pyruvate dehydrogenase | 0.0666 | 0.8409 | 0.8409 |
Schistosoma mansoni | pyruvate dehydrogenase | 0.0629 | 0.7873 | 0.7873 |
Toxoplasma gondii | ATPase/histidine kinase/DNA gyrase B/HSP90 domain-containing protein | 0.027 | 0.2679 | 1 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0085 | 0 | 0.5 |
Echinococcus multilocularis | Pyruvate dehydrogenase (lipoamide) kinase | 0.0666 | 0.8409 | 0.8409 |
Schistosoma mansoni | microtubule-associated protein tau | 0.0776 | 1 | 1 |
Giardia lamblia | Kinase, TTK | 0.0085 | 0 | 0.5 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0085 | 0 | 0.5 |
Echinococcus granulosus | Pyruvate dehydrogenase lipoamide kinase | 0.0666 | 0.8409 | 0.8409 |
Echinococcus multilocularis | microtubule associated protein 2 | 0.0776 | 1 | 1 |
Brugia malayi | kinase, mitochondrial precursor | 0.0666 | 0.8409 | 1 |
Echinococcus multilocularis | Pyruvate dehydrogenase (lipoamide) kinase | 0.0666 | 0.8409 | 0.8409 |
Loa Loa (eye worm) | hypothetical protein | 0.0666 | 0.8409 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (functional) | = 1 | Activity of the compound was determined against isopentenyl pyrophosphate (IPP) in Vgamma9 / Vdelta2 T cell | ChEMBL. | 12657258 |
EC50 (functional) | = 1.02 uM | Mean effective concentration of compound was determined in stimulating Vgamma9 / Vdelta2 T cell | ChEMBL. | 12657258 |
EC50 (functional) | = 4 uM | Effective concentration range of compound was determined in stimulating Vgamma9 / Vdelta2 T cell | ChEMBL. | 12657258 |
EC50 (functional) | = 10 uM | Effective concentration range of compound was determined in stimulating Vgamma9 / Vdelta2 T cell | ChEMBL. | 12657258 |
Production (functional) | = 100 % | Relative yield of the product (FPP) derived from the compound with GPP in the enzymatic reaction catalyzed by FPP synthase from B. stearothermophilus | ChEMBL. | 9873578 |
Production (functional) | = 100 % | Relative yield of the product (FPP) derived from the compound with GPP in the enzymatic reaction catalyzed by FPP synthase from avian liver | ChEMBL. | 9873578 |
Production (functional) | = 100 % | Relative yield of the product (FPP) derived from the compound with GPP in the enzymatic reaction catalyzed by FPP synthase from porcine liver | ChEMBL. | 9873578 |
Production (functional) | = 101 % | Relative yield of the product (FPP) derived from the compound with DMAPP in the enzymatic reaction catalyzed by FPP synthase from porcine liver | ChEMBL. | 9873578 |
Production (functional) | = 105 % | Relative yield of the product (FPP) derived from the compound with DMAPP in the enzymatic reaction catalyzed by FPP synthase from B. stearothermophilus | ChEMBL. | 9873578 |
Production (functional) | = 112 % | Relative yield of the product (FPP) derived from the compound with DMAPP in the enzymatic reaction catalyzed by FPP synthase from avian liver | ChEMBL. | 9873578 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
2 literature references were collected for this gene.