Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | Trypsin family protein | 0.0253 | 1 | 0.5 |
Mycobacterium ulcerans | hypothetical protein | 0.0253 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0253 | 1 | 0.5 |
Echinococcus granulosus | enteropeptidase | 0.0253 | 1 | 0.5 |
Brugia malayi | Trypsin family protein | 0.0253 | 1 | 0.5 |
Echinococcus multilocularis | transmembrane protease serine 3 | 0.0253 | 1 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0253 | 1 | 0.5 |
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | 0.0253 | 1 | 0.5 |
Schistosoma mansoni | cercarial elastase (S01 family) | 0.0253 | 1 | 0.5 |
Echinococcus multilocularis | glycoprotein Antigen 5 | 0.0253 | 1 | 0.5 |
Onchocerca volvulus | 0.0253 | 1 | 0.5 | |
Onchocerca volvulus | 0.0253 | 1 | 0.5 | |
Echinococcus multilocularis | Mastin | 0.0253 | 1 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0253 | 1 | 0.5 |
Schistosoma mansoni | cercarial elastase (S01 family) | 0.0253 | 1 | 0.5 |
Brugia malayi | hypothetical protein | 0.0253 | 1 | 0.5 |
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | 0.0253 | 1 | 0.5 |
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | 0.0253 | 1 | 0.5 |
Echinococcus granulosus | glycoprotein Antigen 5 | 0.0253 | 1 | 0.5 |
Schistosoma mansoni | cercarial elastase (S01 family) | 0.0253 | 1 | 0.5 |
Schistosoma mansoni | cercarial elastase (S01 family) | 0.0253 | 1 | 0.5 |
Onchocerca volvulus | 0.0253 | 1 | 0.5 | |
Schistosoma mansoni | cercarial elastase (S01 family) | 0.0253 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0253 | 1 | 0.5 |
Schistosoma mansoni | cercarial elastase (S01 family) | 0.0253 | 1 | 0.5 |
Brugia malayi | Chymotrypsin-like protease CTRL-1 precursor | 0.0253 | 1 | 0.5 |
Onchocerca volvulus | 0.0253 | 1 | 0.5 | |
Echinococcus granulosus | Mastin | 0.0253 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0253 | 1 | 0.5 |
Echinococcus granulosus | subfamily S1A unassigned peptidase S01 family | 0.0253 | 1 | 0.5 |
Echinococcus multilocularis | enteropeptidase | 0.0253 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0253 | 1 | 0.5 |
Schistosoma mansoni | aminopeptidase PILS (M01 family) | 0.0253 | 1 | 0.5 |
Echinococcus multilocularis | Peptidase S1 S6, chymotrypsin Hap | 0.0253 | 1 | 0.5 |
Brugia malayi | Trypsin-like protease protein 5 | 0.0253 | 1 | 0.5 |
Schistosoma mansoni | cercarial elastase (S01 family) | 0.0253 | 1 | 0.5 |
Schistosoma mansoni | cercarial elastase (S01 family) | 0.0253 | 1 | 0.5 |
Echinococcus granulosus | transmembrane protease serine 3 | 0.0253 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0253 | 1 | 0.5 |
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | 0.0253 | 1 | 0.5 |
Schistosoma mansoni | cercarial elastase (S01 family) | 0.0253 | 1 | 0.5 |
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | 0.0253 | 1 | 0.5 |
Loa Loa (eye worm) | trypsin family protein | 0.0253 | 1 | 0.5 |
Echinococcus granulosus | Peptidase S1 S6 chymotrypsin Hap | 0.0253 | 1 | 0.5 |
Schistosoma mansoni | cercarial elastase (S01 family) | 0.0253 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0253 | 1 | 0.5 |
Onchocerca volvulus | 0.0253 | 1 | 0.5 | |
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | 0.0253 | 1 | 0.5 |
Echinococcus multilocularis | subfamily S1A unassigned peptidase (S01 family) | 0.0253 | 1 | 0.5 |
Mycobacterium tuberculosis | Possible penicillin-binding protein | 0.0227 | 0.7856 | 1 |
Schistosoma mansoni | cercarial elastase (S01 family) | 0.0253 | 1 | 0.5 |
Brugia malayi | Trypsin family protein | 0.0253 | 1 | 0.5 |
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | 0.0253 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0253 | 1 | 0.5 |
Onchocerca volvulus | 0.0253 | 1 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Dose (functional) | = 80 mM kg-1 | Dose of the compound required for antitumor efficacy tested in vivo against primary kidney tumors in murine renal carcinoma (RENCA) | ChEMBL. | 10753462 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.