Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | cyclins | 0.0285 | 0.3893 | 0.3893 |
Echinococcus multilocularis | G2:mitotic specific cyclin B3 | 0.0613 | 1 | 1 |
Brugia malayi | Cyclin, N-terminal domain containing protein | 0.0383 | 0.5714 | 0.5714 |
Trichomonas vaginalis | cyclin B, putative | 0.0285 | 0.3893 | 0.5422 |
Trichomonas vaginalis | cyclin D, putative | 0.0285 | 0.3893 | 0.5422 |
Echinococcus granulosus | cyclins | 0.0285 | 0.3893 | 0.3893 |
Schistosoma mansoni | cyclin B | 0.0383 | 0.5714 | 0.5714 |
Echinococcus multilocularis | cyclins | 0.0285 | 0.3893 | 0.3893 |
Schistosoma mansoni | cyclins | 0.0285 | 0.3893 | 0.3893 |
Brugia malayi | Cyclin, N-terminal domain containing protein | 0.0383 | 0.5714 | 0.5714 |
Echinococcus multilocularis | oligomeric golgi complex subunit 3 | 0.0139 | 0.1163 | 0.1163 |
Echinococcus multilocularis | cyclin B3 1 | 0.0285 | 0.3893 | 0.3893 |
Brugia malayi | Cyclin, N-terminal domain containing protein | 0.0306 | 0.4274 | 0.4274 |
Onchocerca volvulus | 0.0383 | 0.5714 | 0.5 | |
Trichomonas vaginalis | cyclins, putative | 0.0383 | 0.5714 | 1 |
Loa Loa (eye worm) | cyclin domain-containing protein | 0.0613 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0098 | 0.039 | 0.039 |
Brugia malayi | Cyclin C | 0.0139 | 0.1163 | 0.1163 |
Echinococcus multilocularis | cyclin B | 0.0383 | 0.5714 | 0.5714 |
Trichomonas vaginalis | cyclins, putative | 0.0383 | 0.5714 | 1 |
Echinococcus multilocularis | cyclins | 0.0285 | 0.3893 | 0.3893 |
Loa Loa (eye worm) | cyclin C | 0.0139 | 0.1163 | 0.1163 |
Loa Loa (eye worm) | cyclin domain-containing protein | 0.0306 | 0.4274 | 0.4274 |
Toxoplasma gondii | hypothetical protein | 0.0213 | 0.2548 | 0.5 |
Trichomonas vaginalis | cyclins, putative | 0.0383 | 0.5714 | 1 |
Trypanosoma brucei | mitotic cyclin 6 | 0.0383 | 0.5714 | 0.5 |
Giardia lamblia | G2/mitotic-specific cyclin B | 0.0383 | 0.5714 | 1 |
Brugia malayi | Cyclin, N-terminal domain containing protein | 0.0202 | 0.2334 | 0.2334 |
Entamoeba histolytica | cyclin, putative | 0.0383 | 0.5714 | 1 |
Trichomonas vaginalis | cyclins, putative | 0.0383 | 0.5714 | 1 |
Echinococcus multilocularis | cyclins | 0.0285 | 0.3893 | 0.3893 |
Trypanosoma cruzi | cyclin, putative | 0.0383 | 0.5714 | 0.5 |
Trichomonas vaginalis | cyclin B3, putative | 0.0285 | 0.3893 | 0.5422 |
Trypanosoma cruzi | cyclin 6, putative | 0.0383 | 0.5714 | 0.5 |
Loa Loa (eye worm) | cyclin domain-containing protein | 0.0202 | 0.2334 | 0.2334 |
Leishmania major | cyclin | 0.0383 | 0.5714 | 0.5 |
Echinococcus granulosus | cyclins | 0.0285 | 0.3893 | 0.3893 |
Echinococcus granulosus | cyclins | 0.0285 | 0.3893 | 0.3893 |
Loa Loa (eye worm) | hypothetical protein | 0.0383 | 0.5714 | 0.5714 |
Trichomonas vaginalis | cyclin D, putative | 0.0285 | 0.3893 | 0.5422 |
Trichomonas vaginalis | cyclin B, putative | 0.0383 | 0.5714 | 1 |
Plasmodium falciparum | cyclin | 0.0285 | 0.3893 | 0.5 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0285 | 0.3893 | 0.5422 |
Echinococcus granulosus | cyclin | 0.0139 | 0.1163 | 0.1163 |
Echinococcus granulosus | G2:mitotic specific cyclin B3 | 0.0613 | 1 | 1 |
Trypanosoma cruzi | CYC2-like cyclin, putative | 0.0383 | 0.5714 | 0.5 |
Trichomonas vaginalis | cyclin B, putative | 0.0383 | 0.5714 | 1 |
Leishmania major | CYC2-like cyclin, putative,cyclin 6, putative | 0.0383 | 0.5714 | 0.5 |
Trichomonas vaginalis | cyclin A, putative | 0.0383 | 0.5714 | 1 |
Echinococcus granulosus | cyclin b3 | 0.0285 | 0.3893 | 0.3893 |
Echinococcus multilocularis | cyclins | 0.0285 | 0.3893 | 0.3893 |
Echinococcus granulosus | oligomeric golgi complex subunit 3 | 0.0139 | 0.1163 | 0.1163 |
Echinococcus granulosus | cyclin B3 1 | 0.0285 | 0.3893 | 0.3893 |
Echinococcus multilocularis | cyclins | 0.0285 | 0.3893 | 0.3893 |
Loa Loa (eye worm) | hypothetical protein | 0.0383 | 0.5714 | 0.5714 |
Echinococcus granulosus | cyclin B | 0.0383 | 0.5714 | 0.5714 |
Echinococcus multilocularis | cyclin | 0.0139 | 0.1163 | 0.1163 |
Echinococcus multilocularis | cyclin b3 | 0.0285 | 0.3893 | 0.3893 |
Echinococcus granulosus | cyclins | 0.0285 | 0.3893 | 0.3893 |
Trichomonas vaginalis | cyclin B, putative | 0.0383 | 0.5714 | 1 |
Echinococcus granulosus | cyclins | 0.0285 | 0.3893 | 0.3893 |
Echinococcus multilocularis | cyclins | 0.0285 | 0.3893 | 0.3893 |
Trypanosoma cruzi | cyclin, putative | 0.0383 | 0.5714 | 0.5 |
Schistosoma mansoni | cyclin B3 | 0.0613 | 1 | 1 |
Schistosoma mansoni | g1/s-specific cyclin C | 0.0139 | 0.1163 | 0.1163 |
Trichomonas vaginalis | cyclins, putative | 0.0285 | 0.3893 | 0.5422 |
Trichomonas vaginalis | cyclin B, putative | 0.0383 | 0.5714 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity A (functional) | = 1.35 uM kg-1 | Reduction of the integrated electromyographic response by 50% in cat after intravenous administration | ChEMBL. | 7392031 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.