Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | adenylate cyclase 9 | 0.0077 | 0.0235 | 0.5 |
Onchocerca volvulus | 0.0077 | 0.0235 | 0.0235 | |
Brugia malayi | Adenylyl cyclase protein | 0.0077 | 0.0235 | 0.5 |
Onchocerca volvulus | Adenylate cyclase type 2 homolog | 0.0077 | 0.0235 | 0.0235 |
Echinococcus multilocularis | adenylate cyclase 9 | 0.0077 | 0.0235 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.021 | 0.9765 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Affinity (binding) | = 14.2 % | Percentage affinity of compound towards muscarinic receptor sites in the rat cerebral cortex | ChEMBL. | 2918515 |
K1 (ADMET) | = 0.18 min-1 | First order rate constant of compound was determined in 50 mM phosphate buffer (pH 7.4) at 24 degree celsius | ChEMBL. | 2918515 |
K1 (ADMET) | = 0.89 min-1 | First order rate constant of compound was determined in 50 mM phosphate buffer (pH 7.4) at 37 degree celsius | ChEMBL. | 2918515 |
K2 (ADMET) | = 0.0096 min-1 | Rate constant for decay of compound was determined in 50 mM phosphate buffer (pH 7.4) at 24 degree celsius | ChEMBL. | 2918515 |
K2 (ADMET) | = 0.06 min-1 | Rate constant for decay of compound was determined in 50 mM phosphate buffer (pH 7.4) at 37 degree celsius | ChEMBL. | 2918515 |
K3 (ADMET) | = 0.096 min-1 | Rate constants of compound was determined at muscarinic receptor in the rat cerebral cortex | ChEMBL. | 2918515 |
KA (binding) | = 0.035 uM | Dissociation constant of compound was determined at muscarinic receptor in the rat cerebral cortex | ChEMBL. | 2918515 |
KH (binding) | = 0.001 uM | Equilibrium binding parameters of compound was determined at muscarinic receptor in the rat cerebral cortex | ChEMBL. | 2918515 |
KL (binding) | = 0.071 uM | Equilibrium binding parameters of compound was determined at muscarinic receptor in the rat cerebral cortex | ChEMBL. | 2918515 |
LD50 (ADMET) | = 81 uM kg-1 | Acute toxicity of compound when injected intraveneously in mice | ChEMBL. | 2918515 |
LD50 (ADMET) | = 81 uM kg-1 | Acute toxicity of compound when injected intraveneously in mice | ChEMBL. | 2918515 |
Ratio (binding) | = 71 | Ratio of binding constants KL to KH was determined | ChEMBL. | 2918515 |
T1/2 (ADMET) | = 0.8 min | Half life of compound was determined in 50 mM phosphate buffer (pH 7.4) at 37 degree celsius | ChEMBL. | 2918515 |
T1/2 (ADMET) | = 11.6 min | Half life of compound was determined in 50 mM phosphate buffer (pH 7.4) at 37 degree celsius | ChEMBL. | 2918515 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.