Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium ulcerans | ion transport protein | 0.0061 | 0 | 0.5 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0116 | 0.0066 | 1 |
Echinococcus granulosus | potassium voltage gated channel subfamily H | 0.0111 | 0.006 | 0.0392 |
Trypanosoma cruzi | telomerase reverse transcriptase, putative | 0.2266 | 0.2677 | 0.5 |
Echinococcus granulosus | protection of telomeres protein 1 | 0.0568 | 0.0615 | 1 |
Leishmania major | telomerase reverse transcriptase, putative | 0.2266 | 0.2677 | 0.5 |
Trypanosoma brucei | telomerase reverse transcriptase | 0.2266 | 0.2677 | 0.5 |
Giardia lamblia | Telomerase catalytic subunit | 0.2266 | 0.2677 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0112 | 0.0062 | 0.8398 |
Toxoplasma gondii | RNA-directed DNA polymerase | 0.2266 | 0.2677 | 0.5 |
Trypanosoma cruzi | telomerase reverse transcriptase, putative | 0.2266 | 0.2677 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0103 | 0.0051 | 0.7058 |
Loa Loa (eye worm) | hypothetical protein | 0.0112 | 0.0062 | 1 |
Brugia malayi | Telomerase reverse transcriptase | 0.6031 | 0.7248 | 1 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0116 | 0.0066 | 1 |
Plasmodium vivax | telomerase reverse transcriptase, putative | 0.2266 | 0.2677 | 0.5 |
Trichomonas vaginalis | voltage and ligand gated potassium channel, putative | 0.0101 | 0.0047 | 0.5 |
Brugia malayi | Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog | 0.0111 | 0.006 | 0.0031 |
Loa Loa (eye worm) | voltage and ligand gated potassium channel | 0.0111 | 0.006 | 0.9538 |
Plasmodium falciparum | telomerase reverse transcriptase | 0.2266 | 0.2677 | 0.5 |
Echinococcus multilocularis | protection of telomeres protein 1 | 0.0568 | 0.0615 | 1 |
Brugia malayi | hypothetical protein | 0.0112 | 0.0062 | 0.0034 |
Trichomonas vaginalis | voltage and ligand gated potassium channel, putative | 0.0101 | 0.0047 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0112 | 0.0062 | 1 |
Echinococcus multilocularis | potassium voltage gated channel subfamily H | 0.0111 | 0.006 | 0.0392 |
Brugia malayi | hypothetical protein | 0.0112 | 0.0062 | 0.0034 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Antifertility potency (functional) | = 0 | Antifertility activity measured as minimum protective dose for prevention of pregnancy in rats | ChEMBL. | 3560158 |
Estrogenic potency (functional) | = 8 | Evaluation of oral estrogenic activity by using immature female rats ovariectomized at 21 days of age. | ChEMBL. | 3560158 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.