Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | adenosine A2b receptor | Starlite/ChEMBL | References |
Homo sapiens | adenosine A1 receptor | Starlite/ChEMBL | References |
Homo sapiens | adenosine A3 receptor | Starlite/ChEMBL | References |
Homo sapiens | adenosine A2a receptor | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Brugia malayi | hypothetical protein | adenosine A1 receptor | 326 aa | 305 aa | 21.0 % |
Brugia malayi | follicle stimulating hormone receptor | adenosine A2a receptor | 412 aa | 336 aa | 22.3 % |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Ki (binding) | = 120 nM | Displacement of [3H]-SCH- 58261 binding at human Adenosine A2A receptor expressed in HEK-293 cells; ranges from 98-144 | ChEMBL. | 11754583 |
Ki (binding) | = 120 nM | Displacement of [3H]-SCH- 58261 binding at human Adenosine A2A receptor expressed in HEK-293 cells; ranges from 98-144 | ChEMBL. | 11754583 |
Ki (binding) | = 120 nM | Displacement of [3H]NECA from human adenosine A2A receptor expressed in CHO cells | ChEMBL. | 19501513 |
Ki (binding) | = 9399 nM | Displacement of [3H]-DPCPX from human Adenosine A1 receptor expressed in CHO cells; ranges from 9038-9773 | ChEMBL. | 11754583 |
Ki (binding) | = 9399 nM | Displacement of [3H]-DPCPX from human Adenosine A1 receptor expressed in CHO cells; ranges from 9038-9773 | ChEMBL. | 11754583 |
Ki (binding) | > 10000 nM | Displacement of specific [3H]-DPCPX binding at human adenosine A2B receptor expressed in HEK-293 cells. | ChEMBL. | 11754583 |
Ki (binding) | > 10000 nM | Displacement of specific [3H]-MRE3008-F20 binding at human adenosine A3 receptor expressed in CHO cells. | ChEMBL. | 11754583 |
Ki (binding) | > 10000 nM | Displacement of specific [3H]-DPCPX binding at human adenosine A2B receptor expressed in HEK-293 cells. | ChEMBL. | 11754583 |
Ki (binding) | > 10000 nM | Displacement of specific [3H]-MRE3008-F20 binding at human adenosine A3 receptor expressed in CHO cells. | ChEMBL. | 11754583 |
Ki (binding) | > 10000 nM | Displacement of [3H]NECA from human adenosine A3 receptor expressed in CHO cells | ChEMBL. | 19501513 |
Ratio (binding) | > 83 | Selectivity ratio of human adenosine A2B receptor to human adenosine A2A receptor. | ChEMBL. | 11754583 |
Ratio (binding) | = 78 | Selectivity ratio of human adenosine A1 receptor to human adenosine A2A receptor. | ChEMBL. | 11754583 |
Ratio (binding) | > 83 | Selectivity ratio of human adenosine A2B receptor to human adenosine A2A receptor. | ChEMBL. | 11754583 |
Ratio (binding) | > 83 | Selectivity ratio of human adenosine A3 receptor to human adenosine A2A receptor. | ChEMBL. | 11754583 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
2 literature references were collected for this gene.