Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | carboxylesterase 5A | 0.0079 | 0.1884 | 0.1884 |
Echinococcus granulosus | acetylcholinesterase | 0.0079 | 0.1884 | 0.1884 |
Echinococcus granulosus | carboxylesterase 5A | 0.0079 | 0.1884 | 0.1884 |
Echinococcus multilocularis | MAP kinase activated protein kinase 2 | 0.0185 | 1 | 1 |
Echinococcus multilocularis | acetylcholinesterase | 0.0079 | 0.1884 | 0.1884 |
Echinococcus granulosus | acetylcholinesterase | 0.0079 | 0.1884 | 0.1884 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0185 | 1 | 1 |
Echinococcus granulosus | MAP kinase activated protein kinase 2 | 0.0185 | 1 | 1 |
Echinococcus multilocularis | acetylcholinesterase | 0.0079 | 0.1884 | 0.1884 |
Loa Loa (eye worm) | camk/mapkapk/mapkapk protein kinase | 0.0185 | 1 | 1 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0079 | 0.1884 | 0.1884 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Cell survival (functional) | = 82.6 % | In vitro cell growth inhibition of PC3 cell line determined using non-radioactive cell proliferation assay at a dose of 10 uM | ChEMBL. | 11392530 |
Cell survival (functional) | = 82.6 % | In vitro cell growth inhibition of PC3 cell line determined using non-radioactive cell proliferation assay at a dose of 10 uM | ChEMBL. | 11392530 |
Cell survival (functional) | = 91.5 % | In vitro cell growth inhibition of H520 cell line determined using Non-Radioactive Cell Proliferation Assay at a dose of 100 uM | ChEMBL. | 11392530 |
Cell survival (functional) | = 93.8 % | In vitro cell growth inhibition of H520 cell line determined using non-radioactive cell proliferation assay at a dose of 10 uM | ChEMBL. | 11392530 |
Cell survival (functional) | = 95.3 % | In vitro cell growth inhibition of PC3 cell line determined using non-radioactive cell proliferation assay at a dose of 100 uM | ChEMBL. | 11392530 |
Cell survival (functional) | = 95.3 % | In vitro cell growth inhibition of PC3 cell line determined using non-radioactive cell proliferation assay at a dose of 100 uM | ChEMBL. | 11392530 |
Cell survival (functional) | = 99.5 % | In vitro cell growth inhibition of PC3 cell line determined using Non-Radioactive Cell Proliferation Assay at a dose of 50 uM | ChEMBL. | 11392530 |
Cell survival (functional) | = 99.5 % | In vitro cell growth inhibition of PC3 cell line determined using Non-Radioactive Cell Proliferation Assay at a dose of 50 uM | ChEMBL. | 11392530 |
Cell survival (functional) | = 99.7 % | In vitro cell growth inhibition of H520 cell line determined using non-radioactive cell proliferation assay at a dose of 50 uM | ChEMBL. | 11392530 |
DNA relaxation (functional) | 0 | Inhibition of topo II-mediated DNA relaxation measured by topo II-mediated DNA relaxation assay | ChEMBL. | 11392530 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.