Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
-Log ID50 (functional) | = 5.78 | Negative logarithm antagonist concentration causing 50% inhibition of tonic CD response in the guinea pig ileal longitudinal smooth muscle preparation | ChEMBL. | 3560157 |
-Log KD50 (functional) | = 5.6 | Negative log antagonist concentration causing 50% displacement of [3H]-nitrendipine from guinea pig ileal smooth muscle membrane. | ChEMBL. | 3560157 |
ID50 (functional) | = 1.67 M | Inhibition of muscarinic receptor mediated [Ca2+] dependent contraction of guinea pig ileal longitudinal smooth muscle. | ChEMBL. | 3560157 |
ID50 (functional) | = 1.67 M | Inhibition of muscarinic receptor mediated [Ca2+] dependent contraction of guinea pig ileal longitudinal smooth muscle. | ChEMBL. | 3560157 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.