Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | FAD binding domain-containing protein | 0.0049 | 1 | 1 |
Schistosoma mansoni | NADPH flavin oxidoreductase | 0.0025 | 0.0151 | 0.0151 |
Trypanosoma cruzi | NADPH-dependent FMN/FAD containing oxidoreductase, putative | 0.0049 | 1 | 0.5 |
Trypanosoma cruzi | cytochrome P450 reductase, putative | 0.0049 | 1 | 0.5 |
Leishmania major | NADPH-cytochrome p450 reductase-like protein | 0.0049 | 1 | 1 |
Toxoplasma gondii | flavodoxin domain-containing protein | 0.0024 | 0 | 0.5 |
Giardia lamblia | Nitric oxide synthase, inducible | 0.0043 | 0.7743 | 0.5 |
Trypanosoma brucei | NADPH-dependent diflavin oxidoreductase 1 | 0.0049 | 1 | 0.5 |
Trypanosoma brucei | NADPH--cytochrome P450 reductase, putative | 0.0049 | 1 | 0.5 |
Echinococcus granulosus | NADPH cytochrome P450 reductase | 0.0049 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0049 | 1 | 1 |
Schistosoma mansoni | 5-methyl tetrahydrofolate-homocysteine methyltransferase reductase | 0.003 | 0.2407 | 0.2407 |
Trypanosoma cruzi | cytochrome P450 reductase, putative | 0.0049 | 1 | 0.5 |
Echinococcus granulosus | NADPH dependent diflavin oxidoreductase 1 | 0.0049 | 1 | 1 |
Leishmania major | p450 reductase, putative | 0.0049 | 1 | 1 |
Brugia malayi | FAD binding domain containing protein | 0.0049 | 1 | 1 |
Trypanosoma cruzi | p450 reductase, putative | 0.0049 | 1 | 0.5 |
Trichomonas vaginalis | sulfite reductase, putative | 0.0049 | 1 | 1 |
Plasmodium vivax | NADPH-cytochrome p450 reductase, putative | 0.0049 | 1 | 1 |
Schistosoma mansoni | cytochrome P450 reductase | 0.0049 | 1 | 1 |
Giardia lamblia | Hypothetical protein | 0.0043 | 0.7743 | 0.5 |
Chlamydia trachomatis | sulfite reductase | 0.003 | 0.2407 | 0.5 |
Toxoplasma gondii | flavodoxin domain-containing protein | 0.0024 | 0 | 0.5 |
Plasmodium falciparum | nitric oxide synthase, putative | 0.0049 | 1 | 0.5 |
Echinococcus multilocularis | NADPH dependent diflavin oxidoreductase 1 | 0.0049 | 1 | 1 |
Echinococcus multilocularis | NADPH cytochrome P450 reductase | 0.0049 | 1 | 1 |
Trypanosoma brucei | NADPH--cytochrome P450 reductase, putative | 0.0049 | 1 | 0.5 |
Mycobacterium ulcerans | formate dehydrogenase H FdhF | 0.0049 | 1 | 0.5 |
Trypanosoma brucei | NADPH-cytochrome p450 reductase, putative | 0.0049 | 1 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (functional) | = -9 delta mmHg | Compound was tested for its effect on systolic blood pressure in anaesthetized rats after i.v. administration at a dose of 4.12 umol/kg. | ChEMBL. | No reference |
Activity (functional) | = -8 delta mmHg | Compound was tested for its effect on diastolic blood pressure in anaesthetized rats after i.v. administration at a dose of 4.12 umol/kg. | ChEMBL. | No reference |
dP/dt max (functional) | = 648 mmHg s-1 | Compound was tested for cardiac ionotropism and expressed as dP/dtmax. | ChEMBL. | No reference |
HR (functional) | = 4 delta beats min-1 | Compound was tested for its effect on heart rate in anaesthetized rats after i.v. administration at a dose of 4.12 umol/kg | ChEMBL. | No reference |
RF (functional) | = 4 delta beats min-1 | Compound was tested for its effect on respiratory frequency in anaesthetized rats after i.v. administration at a dose of 4.12 umol/kg. | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.