Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium leprae | PROBABLE PHOSPHORIBOSYLAMINE--GLYCINE LIGASE PURD (GARS) (GLYCINAMIDE RIBONUCLEOTIDE SYNTHETASE) (PHOSPHORIBOSYLGLYCINAMIDE SYNT | 0.0754 | 0.4034 | 1 |
Echinococcus multilocularis | folate receptor beta | 0.1707 | 1 | 0.5 |
Onchocerca volvulus | 0.0167 | 0.0353 | 1 | |
Mycobacterium ulcerans | phosphoribosylamine--glycine ligase | 0.0754 | 0.4034 | 1 |
Mycobacterium tuberculosis | Probable phosphoribosylformylglycinamidine CYCLO-ligase PurM (AIRS) (phosphoribosyl-aminoimidazole synthetase) (air synthase) | 0.0167 | 0.0353 | 1 |
Toxoplasma gondii | hypothetical protein | 0.042 | 0.1939 | 0.5 |
Wolbachia endosymbiont of Brugia malayi | phosphoribosylamine--glycine ligase | 0.0754 | 0.4034 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Drug release (ADMET) | = 0 % | Lysozyme-cojugated prodrugs: in vitro stability at pH 5 | ChEMBL. | 1560438 |
Drug release (functional) | = 0 % | Lysozyme-cojugated prodrugs: in vitro stability at pH 7.4 | ChEMBL. | 1560438 |
Drug release (functional) | = 96 % | Lysozyme-cojugated prodrugs: in vitro stability at pH 7.4 | ChEMBL. | 1560438 |
Drug release (functional) | = 100 % | Lysozyme-cojugated prodrugs: in vitro stability at pH 5 | ChEMBL. | 1560438 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.